Polyglandular autoimmune syndromes

Kahaly, George J.; Frommer, Lara

doi:10.1007/s40618-017-0740-9

Cited by 133 publications

(133 citation statements)

References 52 publications

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“…Screening should be performed to detect other endocrine diseases before the development of potentially severe acute complications (eg adrenal crisis or ketoacidosis) or chronic complications (eg mothers with TRAb inducing neonatal thyrotoxicosis, microvascular complications, and early retention of residual pancreatic beta‐cell function in T1DM) 15. Till now the treatment of APS is organ‐specific therapies aiming at replacing the hormonal deficiency of an already destructed glands or preventing the development of complications of subclinically affected organs.…”

Section: Discussionmentioning

confidence: 99%

Induction of remission in autoimmune polyglandular syndrome type three (APS III): An old drug with new perspectives

Allam

El‐Zawawy

2018

Clinical Case Reports

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Key Clinical MessageThe autoimmune polyglandular syndrome is a sequential chain of autoimmune events. Whenever diagnosed, the clinician's target should be induction of remission and if possible hindering its progression especially if associated with refractory vitiligo, resistant Grave's, or unexplained hyperglycemia in T1DM. Azathioprine could be used for induction of remission in autoimmune polyglandular syndrome type three especially with vitiligo and autoimmune thyroiditis.

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Section: Discussionmentioning

confidence: 99%

Induction of remission in autoimmune polyglandular syndrome type three (APS III): An old drug with new perspectives

Allam

El‐Zawawy

2018

Clinical Case Reports

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“…Autoimmune thyroid disease, Addison's disease and type 1 diabetes (T1D) are among the diseases that can be part of the spectrum of PAS [9]. There are three basic subtypes of PAS.…”

Section: Discussionmentioning

confidence: 99%

“…The peak incidence is between the ages of 20 and 60 and there can be many years separating the onset of different PAS illnesses. Many different autoimmune diseases are associated with PAS with the most common ones being thyroid disease (70-75%), T1D (50-60%), and Addison's disease (40%) [9]. Type III PAS can be further subdivided into three categories.…”

Section: Discussionmentioning

confidence: 99%

Polyglandular Autoimmune Syndrome Type IIIB: Hyperthyroidism and Pernicious Anemia, a Reminder of the Past

Oleo¹,

Saldarriaga²,

Silverman³

et al. 2017

J Endocrinol Metab

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Polyglandular autoimmune syndrome (PAS) refers to the coexistence of at least two different glandular autoimmune diseases. There are several different classes of PAS which involve different organs and present at different age ranges. PAS type IIIB, also known as thyrogastric syndrome, refers to the presence of thyroid autoimmune disease in patients with pernicious anemia. We report a case of a 46-year-old female with Graves disease who presented with pyelonephritis and was found to have severe vitamin B12 deficiency due to pernicious anemia. In patients with autoimmune conditions, it is important to be on the lookout for the development of other forms of autoimmune disease.

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“…La exclusión de otras causas, las imágenes sugestivas de supraadrenalitis autoinmune, la asociación con un hipertiroidismo subclínico probablemente debido a un Graves -Basedow, y la presencia de vitíligo nos hace pensar que el paciente presenta una insuficiencia suprarrenal autoinmune, con hiponatremia severa, en el contexto de un síndrome poliglandular autoinmune tipo II (15,16,17).…”

Section: Discussionunclassified

Severe chronic hiponatremia: rare cause of adrenal insufficiency

Santacruz¹,

Benitez²,

Ayala³

et al. 2016

An. Fac. Cienc. Méd. (Asunción)

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RESUMENLa hiponatremia es el trastorno electrolítico más frecuentemente encontrado en la práctica médica cotidiana y puede llegar a afectar a pacientes tanto en el medio hospitalario como el extrahospitalario.Presentamos el caso de un varón que se presentó a nuestro hospital con una causa de hiponatremia severa, de etiología poco convencional, que respondió satisfactoriamente al tratamiento impartido.Palabras clave: hiponatremia, insuficiencia adrenal, osmolalidad. ABSTRACTHyponatremia is the most common electrolyte disorder encountered in everyday medical practice and can affect patients both in hospital and outside the hospital.We report the case of a man who presented to our hospital with a case of severe hyponatremia, of unconventional etiology, who responded satisfactorily to treatment given

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Polyglandular autoimmune syndromes

Cited by 133 publications

References 52 publications

Induction of remission in autoimmune polyglandular syndrome type three (APS III): An old drug with new perspectives

Induction of remission in autoimmune polyglandular syndrome type three (APS III): An old drug with new perspectives

Polyglandular Autoimmune Syndrome Type IIIB: Hyperthyroidism and Pernicious Anemia, a Reminder of the Past

Severe chronic hiponatremia: rare cause of adrenal insufficiency

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