2016
DOI: 10.1021/acs.langmuir.6b01715
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Polyglutamic Acid-Gated Mesoporous Silica Nanoparticles for Enzyme-Controlled Drug Delivery

Abstract: Mesoporous silica nanoparticles (MSNs) are highly attractive as supports in the design of controlled delivery systems that can act as containers for the encapsulation of therapeutic agents, overcoming common issues such as poor water solubility and poor stability of some drugs and also enhancing their bioavailability. In this context, we describe herein the development of polyglutamic acid (PGA)-capped MSNs that can selectively deliver rhodamine B and doxorubicin. PGA-capped MSNs remain closed in an aqueous en… Show more

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Cited by 41 publications
(32 citation statements)
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References 89 publications
(143 reference statements)
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“…Advantages of the enzyme trigger lie in that it can yield rapidly as well as selective targeted drug delivery to cancer cells, leading to improved therapeutic effects . For example, proteases found in the tumor microenvironment have been devoted to enzyme‐mediated DDSs based on polyglutamic acid (PGA) functionalized MSNs (Figure ) . The PGA‐capped MSNs remain closed in an aqueous environment, yet they are able to deliver the cargo in the presence of pronase attributed to the hydrolysis of the peptide bonds in PGA.…”
Section: Stimuli‐responsive Drug Delivery From Polymer‐brush‐grafted mentioning
confidence: 99%
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“…Advantages of the enzyme trigger lie in that it can yield rapidly as well as selective targeted drug delivery to cancer cells, leading to improved therapeutic effects . For example, proteases found in the tumor microenvironment have been devoted to enzyme‐mediated DDSs based on polyglutamic acid (PGA) functionalized MSNs (Figure ) . The PGA‐capped MSNs remain closed in an aqueous environment, yet they are able to deliver the cargo in the presence of pronase attributed to the hydrolysis of the peptide bonds in PGA.…”
Section: Stimuli‐responsive Drug Delivery From Polymer‐brush‐grafted mentioning
confidence: 99%
“…Responsive polymers Synthesis References pH poly(l-histidine) graft to [7] polyaniline graft from [21] poly (acrylic acid) graft to [22] Temperature poly-N-isopropylacrylamide graft from [23] poly(epsilon-caprolactone) graft to [24] poly(ethylene glycol-lactide) graft to [25] Enzyme polyglutamic acid graft from [10] azido-GFLGR 7 RGDS graft to [26] Light azobenzene/b-cyclodextrin graft to [27] 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 controllability over the shape and length of polymers, which is essential for drug delivery and cell targeting. [38]…”
Section: Triggersmentioning
confidence: 99%
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“…42 In this case, polyglutamic-acid was anchored to the surface of MSNs previously modified with APTES thanks to the formation of amide bonds. In the presence of pronase, peptide bonds were cleaved and remarkable cargo release was observed.…”
Section: Proteases and Hydrolysis Of Amide Groupsmentioning
confidence: 99%