Polyglycolide‐based blends for drug delivery: A differential scanning calorimetry study of the melting behavior

Dickers, Kirsten J.; Huatan, Hiep; Cameron, Ruth E.

doi:10.1002/app.12353

Cited by 11 publications

(7 citation statements)

References 9 publications

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“…A weak interaction between high molecular weight polymers can be thermodynamically unfavorable. This would promote the formation of lower stability co‐crystals and result in decreased crystallinity . In addition, the crystallinity of the PGC copolymer also decreased, as is evident from the Δ H f of PGC (35.6 J g −1 ) and that for 2:1 PCL/PGC (5.65 J g −1 ) due to blending with PCL.…”

Section: Resultsmentioning

confidence: 99%

“…This would promote the formation of lower stability co-crystals and result in decreased crystallinity. 37 In addition, the crystallinity of the PGC copolymer also decreased, as is evident from the ΔH f of PGC (35.6 J g −1 ) and that for 2:1 PCL/PGC (5.65 J g −1 ) due to blending with PCL. Overall, PCL/PGC blends exhibited lower crystallinity than the respective pure polymers.…”

Section: Structural Morphological and Thermal Propertiesmentioning

confidence: 93%

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Fibro‐porous poliglecaprone/polycaprolactone conduits: synergistic effect of composition and in vitro degradation on mechanical properties

Patel

Goś

Schindler

et al. 2014

Polymer International

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Blends of poliglecaprone (PGC) and polycaprolactone (PCL) of varying compositions were electrospun into tubular conduits and their mechanical, morphological, thermal and in vitro degradation properties were evaluated under simulated physiological conditions. Generally, mechanical strength, modulus and hydrophilic nature were enhanced by the addition of PGC to PCL. An in vitro degradation study in phosphate-buffered saline (pH 7.3) was carried out for up to 1 month to understand the hydrolytic degradation effect on the mechanical properties in both the longitudinal and circumferential directions. Pure PCL and 4:1 PCL/PGC blend scaffolds exhibited considerable elastic stiffening after a 1 month in vitro degradation. Fourier transform infrared spectroscopic and DSC techniques were used to understand the degradation behavior and the changes in structure and crystallinity of the polymeric blends. A 3:1 PCL/PGC blend was concluded to be a judicious blend composition for tubular grafts based on overall results on the mechanical properties and performance after a 1 month in vitro degradation study.

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Section: Resultsmentioning

confidence: 99%

Section: Structural Morphological and Thermal Propertiesmentioning

confidence: 93%

Fibro‐porous poliglecaprone/polycaprolactone conduits: synergistic effect of composition and in vitro degradation on mechanical properties

Patel

Goś

Schindler

et al. 2014

Polymer International

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“…This has been shown experimentally in several studies involving blends in which one or both components were polyesters. In particular, Dickers et al investigated blends of PGA with PCL, poly( d, l ‐lactide), and poly(3‐hydroxybutyrateco‐3‐hydroxyvalerate) (PHBHV) 23, 24…”

Section: Introductionmentioning

confidence: 99%

Investigating the effect of PGA on physical and mechanical properties of electrospun PCL/PGA blend nanofibers

Aghdam

Najarian

Shakhesi³

et al. 2011

J of Applied Polymer Sci

104

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In the field of tissue engineering there is always a need for new engineered polymeric biomaterials which have ideal properties and functional customization. Unfortunately the demands for many biomedical applications need a set of properties that no polymers can fulfill. One method to satisfy these demands and providing desirable new biomaterials is by mixing two or more polymers. In this work, random nanofibrous blends of poly (e-caprolactone) (PCL) and polyglycolic acid (PGA) with various PCL/PGA compositions (100/0, 80/20, 65/35, 50/50, and 0/100) were fabricated by electrospinning method and characterized for soft-tissue engineering applications. Physical, chemical, thermal, and mechanical properties of PCL/PGA blend nanofibers were measured by scanning electron microscopy (SEM), porosimetry, contact angle measurement, water uptake, attenuated total reflectance Fourier transform-infrared spectroscopy (ATR-FT-IR), Xray diffraction (XRD), differential scanning calorimetric (DSC), dynamic mechanical thermal analysis (DMTA), and tensile measurements. Morphological characterization showed that the addition of PGA to PCL results in an increase in the average diameter of the nanofibers. According to these results, when the amount of PGA in the blend solution increased, the hydrophilicity and water uptake of the nanofibrous scaffolds increased concurrently, approaching those of PGA nanofibers. Differential scanning calorimetric studies showed that the PCL and PGA were miscible in the nanofibrous structure and the mechanical characterization under dry conditions showed that increasing PGA content results in a tremendous increase in the mechanical properties. In conclusion, the random nanofibrous PCL/PGA scaffold used in this study constitutes a promising material for soft-tissue engineering.

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“…Incredible choices in the polymeric designs offer a direct route to optimal carrier design. Different types of implantable devices have been used, such as non-biodegradable silastic tubes which have encountered issues with their removal after the end of treatment [8]; use of poly(lactide-co-glycolide) (PLGA)-based implants which have shown development of fibrous encapsulation around the implant site [9]; and use of high melting-point polymers which limit their application to compounds with high thermal stability [10]. We recently reported that biodegradable polycaprolactone:F68 implants embedded with chemopreventive agents provided sustained release for long duration in vivo [6; 11].…”

Section: Introductionmentioning

confidence: 99%

Multi-layer polymeric implants for sustained release of chemopreventives

et al. 2012

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Poor oral bioavailability limits the use of many chemopreventives in the prevention and treatment of cancer. To overcome this limitation, we report an improvised implant formulation (“coated” implants) using curcumin, individual curcuminoids, withaferin A and oltipraz. This method involves the coating of blank polycaprolactone implants with 20–30 layers of 10–20% polycaprolactone solution in dichloromethane containing 0.5–2% of the test agent. The in vitro release showed that while oltipraz was released with almost zero-order kinetics over eight weeks, curcumin, individual curcuminoids and withaferin A were released with some initial burst. The in vivo release was determined by grafting implants subcutaneously in A/J mice. When delivered by coated implants, oltipraz significantly diminished lung DNA adducts in mice treated with dibenzo[a, l]pyrene compared with sham treatment (28±7 versus 54±17 adducts/109 nucleotides). Withaferin A also diminished DNA adducts, but it was insignificant. Curcumin and individual curcuminoids were ineffective. Analysis of lung, liver and brain by UPLC-fluorescence showed the presence of the three test curcuminoids indicating effectiveness of the implant delivery system. Further, based on its known antitumor activity in vivo, withaferin A given via the implants significantly inhibited human lung cancer A549 xenograft in athymic nude mice, while it was ineffective when the same total dose was administered i.p. and required over 2-fold higher dose to elicit effectiveness. Together, our data suggest that coated polymeric implants can accommodate heat-labile compounds, can furnish sustained release for long duration, and elicit DNA damage-inhibiting and anti-tumor activities.

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Polyglycolide‐based blends for drug delivery: A differential scanning calorimetry study of the melting behavior

Cited by 11 publications

References 9 publications

Fibro‐porous poliglecaprone/polycaprolactone conduits: synergistic effect of composition and in vitro degradation on mechanical properties

Fibro‐porous poliglecaprone/polycaprolactone conduits: synergistic effect of composition and in vitro degradation on mechanical properties

Investigating the effect of PGA on physical and mechanical properties of electrospun PCL/PGA blend nanofibers

Multi-layer polymeric implants for sustained release of chemopreventives

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