Polygonapholine, an alkaloid with a novel skeleton, isolated from Polygonatum alte-lobatum

Lin, Chun‐Nan; Huang, Po-Chin; Lu, Can‐Zhong; Wu, Ru‐Rong; Hu, Wan‐Ping; Wang, Jhi-Joung

doi:10.1016/s0040-4020(96)01165-9

Cited by 21 publications

(33 citation statements)

References 3 publications

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“…Recently, the plant is being used as a component of a herbal drink in Taiwan. Two new homologous series of 1,4-benzoquinones, 13 known compounds, and a novel alkaloid, polygonapholine, were isolated from rhizomes of P. alte-lobatum [ 12 , 13 ]. However, little information is available on the pharmacological activities of the plant, except for our previous study on its hypolipidemic activity [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Antifatigue Activities of Polygonatum Alte-lobatum Hayata Rhizomes in Rats

et al. 2014

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Polygonatum alte-lobatum Hayata, a rhizomatous perennial herb, belongs to the Liliaceae family and is endemic to Taiwan. We investigated the antioxidant and anti-fatigue activities of P. alte-lobatum in exercised rats. Levels of polyphenols, flavonoids and polysaccharides and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging activity were measured in extracts of P. alte-lobatum (EPA). Sprague-Dawley rats were randomly divided into four groups for 8-week treatment with vehicle (control) and low-, medium-, and high-dose EPA (LEPA, MEPA, HEPA; 0, 75, 150, and 375 mg/kg/day, respectively). Exercise performance was evaluated by exhaustive treadmill exercise time and by changes in body composition and biochemical variables at the end of the experiment. EPA contained polyphenols, flavonoids and polysaccharides, with polysaccharide content at least 26 times greater than that of polyphenols and flavonoids. Trend analysis revealed that EPA dose-dependently scavenged DPPH free radicals. EPA treatment dose-dependently increased endurance running time to exhaustion and superoxide dismutase activity and total antioxidant ability of blood. EPA dose-dependently decreased serum urea nitrogen and malondialdehyde levels after exercise. Hepatic glycogen content, an important energy source for exercise, was significantly increased with EPA treatment. EPA could be a potential agent with an anti-fatigue pharmacological function.

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Section: Introductionmentioning

confidence: 99%

Antioxidant and Antifatigue Activities of Polygonatum Alte-lobatum Hayata Rhizomes in Rats

et al. 2014

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“…Lin and co-workers reported the isolation of polygonapholine (3) from a methanol extract of the rhizome of Polygonatum alte-lobatum, which had been used as a tonic drug in Taiwan (Figure 1). 2 The structure of this novel alkaloid was determined by using spectroscopic methods in combination with molecular modeling. Both morpholine C-substituents are cis-oriented so that they are occupying equatorial positions in the six-membered ring.…”

Section: Naturally Occurring Morpholinesmentioning

confidence: 99%

“…In 1956 the first synthesis of an enantiomerically pure morpholine was reported. 1 L-Ephedrine (1) was reacted with chloroethanol to give phendimetrazine (2).…”

Section: Introductionmentioning

confidence: 99%

Biological Relevance and Synthesis of C-Substituted Morpholine Derivatives

Wijtmans¹,

Vink²,

Schoemaker³

et al. 2004

Synthesis

105

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“…К биологически активным морфолинсодержащим соединениям природного происхождения относятся полигонафолин (алкалоид купены Polygonatum altelobatum) [15], хелонины А и С (алкалоиды губки Chelonaplysilla sp.) [16], а также оксазинины -токсины черноморской мидии Mytilus galloprovincialis [17].…”

Section: Introductionunclassified

Morpholine derivatives as potential agents for neurological manifestations of nervous system diseases

et al. 2020

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Diseases of the nervous system, especially those of vascular, traumatic, and neurodegenerative nature, are characterized by high prevalence, disability and mortality rates, and therefore have a particularly big medical and social impact. Currently, pharmacotherapy options for these diseases are limited to a relatively small number of clinically proven drugs, which is largely due to the difficulties associated with the translation of preclinical studies results. This explains the essential importance of discovering and developing new drugs, both effective and safe, that could be used to reduce clinical manifestations of neurological disorders. The present review is aimed to give a detailed account of several biologically active derivatives of morpholine, a six-membered heterocyclic compound. As demonstrated by a number of in vitro and in vivo studies using cell and animal models, morpholine derivatives should be considered viable drug candidates for a broad range of neurological diseases.

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Polygonapholine, an alkaloid with a novel skeleton, isolated from Polygonatum alte-lobatum

Cited by 21 publications

References 3 publications

Antioxidant and Antifatigue Activities of Polygonatum Alte-lobatum Hayata Rhizomes in Rats

Antioxidant and Antifatigue Activities of Polygonatum Alte-lobatum Hayata Rhizomes in Rats

Biological Relevance and Synthesis of C-Substituted Morpholine Derivatives

Morpholine derivatives as potential agents for neurological manifestations of nervous system diseases

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