Polygonum aviculare L. extract reduces fatigue by inhibiting neuroinflammation in restraint-stressed mice

Park, Sun Haeng; Jang, Seol; Son, Eunjung; Lee, Si Woo; Park, Sun Dong; Sung, Yoon‐Young; Kim, Ho Kyoung

doi:10.1016/j.phymed.2018.03.042

Cited by 27 publications

(14 citation statements)

References 31 publications

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“…Since neuroinflammation plays a causative role in the pathophysiology of depression, targeting this pathway may hold promise for targeted therapy. Furthermore, several studies have proven that acute or chronic RS up-regulates pro-inflammatory cytokines associated with the development of depressive-like behaviors (56,57). Similarly, we found that RS led to the up-regulation of NF-κB, TNF-α, and IL-6 protein expressions in the PFC and HIP subregions.…”

Section: Discussionsupporting

confidence: 77%

Antidepressant and Anxiolytic Effect of Echium amoenum in Restraint Stress Model: The Role of Neuroinflammation in the Prefrontal Cortex and Hippocampus

Nouri

Farajdokht

Torbati

et al. 2019

Iran Red Crescent Med J

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Background: Echium amoenum (E. amoenum) is an Iranian medicinal plant with mood-enhancing effects. Objectives: This study was designed to investigate the effect of standardized E. amoenum hydroalcoholic extract on restraint stress (RS)-evoked anxiety-and-depressive-like behaviors in mice. Methods: This experimental study was conducted at the Tabriz University of Medical Sciences, Tabriz, Iran, in 2018. Doses of the hydroalcoholic extract of E. amoenum were optimized for rosmarinic acid (> %2 w/w) concentration of the extract. Other phytochemical indices, including total phenolic and flavonoid contents and radical scavenging activity, were also measured. For behavioral studies, 65 mice were randomly assigned into five groups (n = 13) of control, RS, RS + E75, RS + E150, and RS + E300. Animals in the RS group were subjected to the RS (3 h/day for 14 days) and treated with normal saline, while treatment groups received E. amoenum extract (75, 150, and 300 mg/kg, p.o.) concomitantly with RS exposure. Anxiety-like behaviors were assessed by Elevated Plus Maze (EPM) and Open Field Test (OFT). Depression was assessed by the forced swim test (FST) and Tail Suspension Test (TST). Western blotting was performed to determine the protein levels of IL-1β, NF-κB, TNF-α, and IL-6 in the prefrontal cortex (PFC) and hippocampus (HIP). The concentrations of corticosterone, alanine aminotransferase, aspartate aminotransferase, and alanine phosphatase were also measured in serum. Results: Moderate and high doses of the extract ameliorated RS-induced anxiety-(P < 0.05 in OFT and EPM) and depressive-like (P < 0.05 and P < 0.01 in FST; P < 0.01 and P < 0.001 in TST) behaviors. These results were approved by decreased serum corticosterone levels (P < 0.05 and P < 0.001). Furthermore, E. amoenum reduced the protein expression of neuroinflammatory markers in the HIP and PFC subregions (significant at least at P < 0.05 for IL-1β, NF-κB, and TNF-α). Although RS slightly increased the serum levels of liver enzymes, no histopathological changes were seen in the liver of the RS or E. amoenum-treated groups. Conclusions: E. amoenum can be an effective and safe complementary strategy for the treatment of stress-associated inflammation and behavioral changes.

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Section: Discussionsupporting

confidence: 77%

Antidepressant and Anxiolytic Effect of Echium amoenum in Restraint Stress Model: The Role of Neuroinflammation in the Prefrontal Cortex and Hippocampus

Nouri

Farajdokht

Torbati

et al. 2019

Iran Red Crescent Med J

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“…Studies have shown that anti-inflammatory treatment can relieve fatigue; for example, selective 5-HT reuptake inhibitors exhibit the most beneficial effects in restraining the inflammation markers in patients with depression [39]. Certain anti-inflammatory preparations can also attenuate fatigue symptoms [40, 41]. However, in the process of theoretical research towards clinical application, there still exist many problems waiting to be solved, such as safety, and there are no commercially available preparations to choose from as well.…”

Section: Discussionmentioning

confidence: 99%

Effect of the Chinese Medicine YangZheng XiaoJi on Reducing Fatigue in Mice with Orthotopic Transplantation of Colon Cancer

Zhang

Zhao

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Background. Fatigue is a common, distressing, and persistent symptom for patients with malignant tumor including colorectal cancer (CRC). Although studies of cancer-related fatigue (CRF) have sprung out in recent years, the pathophysiological mechanisms that induce CRF remain unclear, and effective therapeutic interventions have yet to be established. Methods. To investigate the effect of the traditional Chinese medicine YangZheng XiaoJi (YZXJ) on CRF, we constructed orthotopic colon cancer mice, randomly divided into YZXJ group and control (NS) group. Physical or mental fatigue was respectively assessed by swimming exhaustion time or suspension tail resting time. At the end of the experiment, serum was collected to measure the expression level of inflammatory factors by ELISA and feces to microbiota changes by 16s rDNA, and hepatic glycogen content was detected via the anthrone method. Result. The nutritional status of the YZXJ group was better than that of the control group, and there was no statistical difference in tumor weight. The swimming exhaustion times of YZXJ group and control group were (162.80 ± 14.67) s and (117.60 ± 13.42, P < 0.05) s, respectively; the suspension tail resting time of YZXJ group was shorter than that of the control group (49.85 ± 4.56) s and (68.83 ± 7.26) s, P < 0.05)). Serum levels of IL-1β and IL-6 in YZXJ group were significantly lower than the control group (P < 0.05). Liver glycogen in YZXJ group was (5.18 ± 3.11) mg/g liver tissue, which was significantly higher than that in control group (2.95 ± 2.06) mg/g liver tissue (P < 0.05). At phylum level, increased abundance of Bacteroidetes, Verrucomicrobia, Actinobacteria, and Cyanobacteria and decreased Proteobacteria in YZXJ group emerged as the top differences between the two groups, and the Firmicutes/Bacteroidetes ratio was decreased in YZXJ group compared to the control group. At genus level, the abundance of Parabacteroides, unidentified Saprospiraceae, and Elizabethkingia which all belong to phylum Bacteroidetes were increased, while Arcobacter, Marinobacter, Alkanindiges, Sulfuricurvum, Haliangium, and Thiobacillus in phylum Proteobacteria were decreased after YZXJ intervention. YZXJ can also increase Pirellula, Microbacterium, and Alpinimonas and decrease Rubrobacter and Iamia. Conclusion. YZXJ may reduce the physical and mental fatigue caused by colorectal cancer by inhibiting inflammatory reaction, promoting hepatic glycogen synthesis, and changing the composition of intestinal microbiota.

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“…Avicularin, a quercetin derivative exhibits anti-inflammatory activity such as suppression of NO and PGE2 production and cytokine release by presumably inhibiting nuclear translocation of NF-κB in LPS-stimulated RAW 264.7 macrophage cells [29]. In another study, pretreatment with avicularin isolated from Polygonum aviculare decreased TNF-α protein expression in H2O2 induced neuronal cells [30]. Other isolated flavan derivative EGC decreased proinflammatory cytokines (IL-6, TNF-a) and NO levels in LPS stimulated neutrophils via suppressing the activation of TLR-4/NFκB p65 signal pathway [31].…”

Section: Cell Viability and Quantitative Real-time Pcrmentioning

confidence: 99%

Bioactivity-Guided Isolation of Anti-Inflammatory Principles from Cistus parviflorus Lam.

Gürbüz¹,

Doğan²,

Celik³

et al. 2019

Rec.Nat.Prod.

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Bioactivity-guided fractionation and purification of Cistus parviflorus led to the isolation of two flavan-3-ol derivatives; gallocatechin (1) and epigallocatechin (2) and two flavonoid glycosides; avicularin (3) and trans-tiliroside (4). The structures of the compounds were elucidated on the basis of NMR and ESIMS data. All compounds were isolated from C. parviflorus for the first time. Compounds 2 and 3 exhibited antiinflammatory activity through decreasing the NOS2 and COX2 levels on LPS+IFN-γ treated RAW 264.7 cells. Molecular docking studies of avicularin, the most potent compound, were carried out in the active sites of NOS2 and COX2 to predict the most plausible binding modes and support the experimental data.

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Polygonum aviculare L. extract reduces fatigue by inhibiting neuroinflammation in restraint-stressed mice

Cited by 27 publications

References 31 publications

Antidepressant and Anxiolytic Effect of Echium amoenum in Restraint Stress Model: The Role of Neuroinflammation in the Prefrontal Cortex and Hippocampus

Antidepressant and Anxiolytic Effect of Echium amoenum in Restraint Stress Model: The Role of Neuroinflammation in the Prefrontal Cortex and Hippocampus

Effect of the Chinese Medicine YangZheng XiaoJi on Reducing Fatigue in Mice with Orthotopic Transplantation of Colon Cancer

Bioactivity-Guided Isolation of Anti-Inflammatory Principles from Cistus parviflorus Lam.

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