2013
DOI: 10.1186/1472-6882-13-282
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Polygonum cuspidatum inhibits pancreatic lipase activity and adipogenesis via attenuation of lipid accumulation

Abstract: BackgroundObesity causes metabolic disease and is a serious health problem around the world. Polygonum cuspidatum (POCU1b) has been used clinically for the treatment of constipation, gallstones, hepatitis, and inflammation in East Asian countries. The principal aim of this study was to investigate for the first time whether the extract of Polygonum cuspidatum (POCU) biologically affects adipogenesis in 3 T3-L1 preadipocytes.MethodsFractions (n-hexan, ethyl acetate, n-butanol, and water) of POCU ethanol extract… Show more

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Cited by 15 publications
(12 citation statements)
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“…In an animal model, Bralley et al demonstrated that PCE reduced edemas and inhibited leukocyte infiltration to a greater extent than indomethacin, which is a potent anti-inflammatory drug [ 30 ]. In addition, previous studies have shown that an extract of P. cuspidatum radix exerted an inhibitory effect on RAGE and VEGF expression in diabetic nephropathy [ 15 ] and exhibited strong anti-lipase activity [ 31 ]. These investigations have supported the notion that PCE has anti-inflammatory, anti-lipase, and anti-diabetic effects.…”
Section: Discussionmentioning
confidence: 99%
“…In an animal model, Bralley et al demonstrated that PCE reduced edemas and inhibited leukocyte infiltration to a greater extent than indomethacin, which is a potent anti-inflammatory drug [ 30 ]. In addition, previous studies have shown that an extract of P. cuspidatum radix exerted an inhibitory effect on RAGE and VEGF expression in diabetic nephropathy [ 15 ] and exhibited strong anti-lipase activity [ 31 ]. These investigations have supported the notion that PCE has anti-inflammatory, anti-lipase, and anti-diabetic effects.…”
Section: Discussionmentioning
confidence: 99%
“…An ethanolic extract of P. cuspidatum has been demonstrated to exhibit comprehensive and suppressive effects on inflammatory and oxidative stresses [ 39 ] and significantly enhance the rate of wound healing in rats and humans [ 40 , 41 ]. In our previous study, an extract of P. cuspidatum radix has been shown to exhibit strong anti-lipase activity [ 42 ]. Resveratrol is a natural anti-oxidant polyphenol that is present in P. cuspidatum and has received increased attention in recent years.…”
Section: Discussionmentioning
confidence: 99%
“…The n-butanol fraction of the Polygonum cuspidatum extract exerted significant inhibitory activities on adipogenesis in a dose-dependent manner, evidenced by the reduced formation of lipid droplets and decreased glycerol-3-phosphate dehydrogenase activity. Adipogenesis marker proteins and genes were also decreased [196].…”
Section: From Rootsmentioning
confidence: 96%