Polygonum minus essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathways

Rashid, Norhashima Abd; Hussan, Farida; Hamid, Asmah; Ridzuan, Nurul Raudzah Adib; Halim, Syarifah Aisyah Syed Abd; Jalil, Nahdia Afiifah Abdul; Najib, Nor Haliza Mohamad; Teoh, Seong Lin; Budin, Siti Balkis

doi:10.17179/excli2020-2355

Cited by 8 publications

(4 citation statements)

References 81 publications

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“…DHA supplementation promotes the reduction of IL-10 synthesis by conferring cardioprotection in a myocardial injury model 34 . A study with the essential oil of Polygonum minus identified BCP as one of its components and used it as a positive control in the cisplatin-induced hepatotoxicity model, demonstrating a reduction in the concentration of IL-10 and, therefore, hepatoprotection 35 . Therefore, the reduction in our study demonstrates protection against exacerbation of inflammation during the infectious process.…”

Section: Discussionmentioning

confidence: 99%

β-caryophyllene and docosahexaenoic acid, isolated or associated, have potential antinociceptive and anti-inflammatory effects in vitro and in vivo

Sousa

Oliveira

Selis

et al. 2022

Sci Rep

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Inflammation is a complex biological response involving the immune, autonomic, vascular, and somatosensory systems that occurs through the synthesis of inflammatory mediators and pain induction by the activation of nociceptors. Staphylococcus aureus, the main cause of bacteremia, is one of the most common and potent causes of inflammation in public health, with worse clinical outcomes in hospitals. Antioxidant substances have been evaluated as alternative therapeutic analgesics, antioxidants, anti-inflammatory agents, antitumor agents, and bactericides. Among these, we highlight the essential oils of aromatic plants, such as β-caryophyllene (BCP), and polyunsaturated fatty acids, such as docosahexaenoic acid (DHA). The objective of this study was to evaluate the biological activities of BCP–DHA association in in vitro and in vivo experimental models of antinociception and inflammation. To determine the anti-inflammatory effects, monocytes isolated from the peripheral blood of adult male volunteers were infected with methicillin-resistant S. aureus and incubated with treatment for cytokine dosage and gene expression analysis. Antinociceptive effects were observed in the three models when comparing the control (saline) and the BCP-DHA treatment groups. For this purpose, the antinociceptive effects were evaluated in animal models using the following tests: acetic acid-induced abdominal writhing, paw edema induced by formalin intraplantar injection, and von Frey hypernociception. There was a significant reduction in the GM-CSF, TNFα, IL-1, IL-6, and IL-12 levels and an increase in IL-10 levels in the BCP-DHA treatment groups, in addition to negative regulation of the expression of the genes involved in the intracellular inflammatory signaling cascade (IL-2, IL-6, IRF7, NLRP3, and TYK2) in all groups receiving treatment, regardless of the presence of infection. Statistically significant results (p < 0.05) were obtained in the acetic acid-induced abdominal writhing test, evaluation of paw edema, evaluation of paw flinching and licking in the formalin intraplantar injection model, and the von Frey hypernociception test. Therefore, BCP and DHA, either administered individually or combined, demonstrate potent anti-inflammatory and antinociceptive effects.

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Section: Discussionmentioning

confidence: 99%

β-caryophyllene and docosahexaenoic acid, isolated or associated, have potential antinociceptive and anti-inflammatory effects in vitro and in vivo

Sousa

Oliveira

Selis

et al. 2022

Sci Rep

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“…According to Abd Rashid et al [ 181 ], cisplatin increased pro-inflammatory cytokine levels in the hepatic tissues (TNF-α, IL-1β, IL-1α, and IL-6) despite reducing levels of the anti-inflammatory cytokine IL-10. However, the liver inflammation brought on by cisplatin was successfully reduced when P. minus essential oil was administered at a dose of 100 mg/kg, which also reduced the levels of IL-6, IL-1α, IL-1β, and TNF-α while raising the level of IL-10.…”

Section: Pharmacological Usesmentioning

confidence: 99%

The genus Polygonum: An updated comprehensive review of its ethnomedicinal, phytochemical, pharmacological activities, toxicology, and phytopharmaceutical formulation

Idoudi,

Tourrette,

Bouajila

et al. 2024

Heliyon

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“…Natural products (NP) derived from plants could be an alternative source of promising drugs to mitigate the harmful aftereffects of MIRI. NP offers various medicinal values and health benefits [ 8 , 9 , 10 , 11 , 12 ], including to the heart attributed to anti-apoptotic, antioxidant, and anti-inflammatory properties [ 13 , 14 , 15 , 16 , 17 ]. Furthermore, accumulating studies suggest bioactive compounds and extracts of NPs improved the viability of cardiomyocytes in post-MIRI, ameliorated endothelial function, and modulated the inflammatory and stress process [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Natural Products Targeting PI3K/AKT in Myocardial Ischemic Reperfusion Injury: A Scoping Review

et al. 2023

Self Cite

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This scoping review aimed to summarize the effects of natural products targeting phosphoinositide-3-kinases/serine/threonine kinase (PI3K/AKT) in myocardial ischemia-reperfusion injury (MIRI). The review details various types of natural compounds such as gypenoside (GP), gypenoside XVII (GP-17), geniposide, berberine, dihydroquercetin (DHQ), and tilianin which identified to reduce MIRI in vitro and in vivo by regulating the PI3K/AKT signaling pathway. In this study, 14 research publications that met the inclusion criteria and exclusion criteria were shortlisted. Following the intervention, we discovered that natural products effectively improved cardiac functions through regulation of antioxidant status, down-regulation of Bax, and up-regulation of Bcl-2 and caspases cleavage. Furthermore, although comparing outcomes can be challenging due to the heterogeneity in the study model, the results we assembled here were consistent, giving us confidence in the intervention’s efficacy. We also discussed if MIRI is associated with multiple pathological condition such as oxidative stress, ERS, mitochondrial injury, inflammation, and apoptosis. This brief review provides evidence to support the huge potential of natural products used in the treatment of MIRI due to their various biological activities and drug-like properties.

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Polygonum minus essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathways

Cited by 8 publications

References 81 publications

β-caryophyllene and docosahexaenoic acid, isolated or associated, have potential antinociceptive and anti-inflammatory effects in vitro and in vivo

β-caryophyllene and docosahexaenoic acid, isolated or associated, have potential antinociceptive and anti-inflammatory effects in vitro and in vivo

The genus Polygonum: An updated comprehensive review of its ethnomedicinal, phytochemical, pharmacological activities, toxicology, and phytopharmaceutical formulation

Natural Products Targeting PI3K/AKT in Myocardial Ischemic Reperfusion Injury: A Scoping Review

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