Polyhedral octasilsesquioxanes labelled with the photosensitive cationic phenosafranin dye as a new nanocarrier for therapy and cellular imaging

Rózga-Wijas, K.; Sierant, Małgorzata; Wielgus, Ewelina; Miksa, Beata

doi:10.1016/j.dyepig.2018.09.067

Cited by 10 publications

(5 citation statements)

References 43 publications

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“…Furthermore, a polyhedral oligomeric silsesquioxane (POSS) [272] with optical transparency was covalently tethered to PSF dye molecules (POSS-PSF; 71) forming a new organic- inorganic hybrid that can be used in fluorescent imaging for the spatial and temporal visualization of bio-species in living systems. [273] The photosensitive nanodots fulfill the requirements of green chemistry due to their excellent biocompatibility. Thus, they are ideally suited for probes used in bioimaging and different biomedical purposes, e. g., in photodynamic therapy (PDT).…”

Section: Phenosafranin Hybrid Conjugatesmentioning

confidence: 99%

“…They can be easily transferred by cellular pores either as individual entities or as selfassembled nanostructures with a spherical shape, which are well dispersed and have uniform size distribution due to positively charged PSF moieties. [273] In vitro experiments using HeLa eukaryotic neoplastic cells revealed that POSS-PSF nanodots were noncytotoxic and can be easily internalized by cells through diffusion rather than endocytosis. Apart from enhanced cellular uptake of POSS-PSF which exhibited a lack of cytotoxicity, preliminary data provided evidence that nanodots can intercalate DNA.…”

Section: Phenosafranin Hybrid Conjugatesmentioning

confidence: 99%

“…Thus, PSF‐Biot and PSF‐Chl may prove to be useful forerunners in the design of new anticancer pharmacological agents. Furthermore, a polyhedral oligomeric silsesquioxane (POSS) [272] with optical transparency was covalently tethered to PSF dye molecules (POSS‐PSF; 71 ) forming a new organic‐inorganic hybrid that can be used in fluorescent imaging for the spatial and temporal visualization of bio‐species in living systems [273] . The photosensitive nanodots fulfill the requirements of green chemistry due to their excellent biocompatibility.…”

Section: Phenosafranin Hybrid Conjugatesmentioning

confidence: 99%

“…The POSS‐PSF hybrid conjugates are urgently required for specific in vitro and in vivo applications. They can be easily transferred by cellular pores either as individual entities or as self‐assembled nanostructures with a spherical shape, which are well dispersed and have uniform size distribution due to positively charged PSF moieties [273] . In vitro experiments using HeLa eukaryotic neoplastic cells revealed that POSS‐PSF nanodots were non‐cytotoxic and can be easily internalized by cells through diffusion rather than endocytosis.…”

Section: Phenosafranin Hybrid Conjugatesmentioning

confidence: 99%

See 3 more Smart Citations

The Phenazine Scaffold Used as Cytotoxic Pharmacophore Applied in Bactericidal, Antiparasitic and Antitumor Agents

Miksa

2022

Helvetica Chimica Acta

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Phenazine derivatives are important bactericidal antibiotics and antiparasitic compounds which can be used in synergistic combinations with anticancer drugs in chemotherapy treatments. The development of synthetic phenazines with anticancer activity improves the effectiveness of chemotherapy. Chemical variations introduced at the phenazine core which is known as a chromophore with fluorescent properties provide advanced theranostic agents useful in optical bioimaging techniques and photodynamic anticancer therapy. This review summarizes the field of structural modifications of phenazine derivatives which have been tested against different parasitic and bacterial infections. The report highlights advances in design and biological evaluations of phenazines as anticancer drugs for the development of new chemotherapeutic as well as bio‐imaging reagents.

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Section: Phenosafranin Hybrid Conjugatesmentioning

confidence: 99%

Section: Phenosafranin Hybrid Conjugatesmentioning

confidence: 99%

Section: Phenosafranin Hybrid Conjugatesmentioning

confidence: 99%

Section: Phenosafranin Hybrid Conjugatesmentioning

confidence: 99%

See 2 more Smart Citations

The Phenazine Scaffold Used as Cytotoxic Pharmacophore Applied in Bactericidal, Antiparasitic and Antitumor Agents

Miksa

2022

Helvetica Chimica Acta

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“…Miksa and coworkers have developed biocompatible POSS-based phenosafranin dye (PSF) nanohybrids using a coupling chemistry for drug delivery and diagnostics [105]. PSF is used as a photosensitizer, and a biological probe acts as a nucleic acid intercalator and human ribonuclease reductase inhibitor.…”

Section: Poss For Delivery Of Contrast Agentsmentioning

confidence: 99%

Use of Polyhedral Oligomeric Silsesquioxane (POSS) in Drug Delivery, Photodynamic Therapy and Bioimaging

2021

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Polyhedral oligomeric silsesquioxanes (POSS) have attracted considerable attention in the design of novel organic-inorganic hybrid materials with high performance capabilities. Features such as their well-defined nanoscale structure, chemical tunability, and biocompatibility make POSS an ideal building block to fabricate hybrid materials for biomedical applications. This review highlights recent advances in the application of POSS-based hybrid materials, with particular emphasis on drug delivery, photodynamic therapy and bioimaging. The design and synthesis of POSS-based materials is described, along with the current methods for controlling their chemical functionalization for biomedical applications. We summarize the advantages of using POSS for several drug delivery applications. We also describe the current progress on using POSS-based materials to improve photodynamic therapies. The use of POSS for delivery of contrast agents or as a passivating agent for nanoprobes is also summarized. We envision that POSS-based hybrid materials have great potential for a variety of biomedical applications including drug delivery, photodynamic therapy and bioimaging.

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Thermostable Fluorescent Capsules with the Cross‐Linked Heterocyclic Polymer Shell from Poly(pyrrole‐phenosafranin)

Miksa

Steinke

Trzeciak

et al. 2021

Macro Chemistry & Physics

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The present investigation describes the synthesis of capsules with a poly(pyrrole‐phenosafranin) cross‐linked shell. The capsules are prepared in a water solution by the facile single‐step chemical oxidative polymerization of monomers within hydrophobic interior of lipid bilayers that act as temporary scaffolds created by liposomes from 1,2‐dilauroyl‐sn‐glycero‐3‐phosphatidylcholine. The polypyrrole links phenosafranin units via amino groups, thus new thermostable nanocapsules are obtained without additional cross‐linking agents. Their spherical shape is confirmed by electron microscopy. Wide spectral characteristics of capsules by using different analytical methods provide detailed information about their structures.

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Polyhedral octasilsesquioxanes labelled with the photosensitive cationic phenosafranin dye as a new nanocarrier for therapy and cellular imaging

Cited by 10 publications

References 43 publications

The Phenazine Scaffold Used as Cytotoxic Pharmacophore Applied in Bactericidal, Antiparasitic and Antitumor Agents

The Phenazine Scaffold Used as Cytotoxic Pharmacophore Applied in Bactericidal, Antiparasitic and Antitumor Agents

Use of Polyhedral Oligomeric Silsesquioxane (POSS) in Drug Delivery, Photodynamic Therapy and Bioimaging

Thermostable Fluorescent Capsules with the Cross‐Linked Heterocyclic Polymer Shell from Poly(pyrrole‐phenosafranin)

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