Polyhedral Organic Microcrystals: From Cubes to Rhombic Dodecahedra

Zhang, Xiujuan; Dong, C.; Zapien, Juan���Antonio; Ismathullakhan, Shafiq; Kang, Zhenhui; Jie, Jiansheng; Zhang, Xiaohong; Chang, Jack���C.; Lee, Chun‐Sing; Lee, Shuit‐Tong

doi:10.1002/ange.200902929

Cited by 31 publications

(35 citation statements)

References 29 publications

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“…5 mm in width) has a D 4h symmetry with four sails, in which the dihedral angles among the sails are almost 90 degrees. [21,22] The SEM image showed that the self-assembly of ACPC 7 produced the rodlike 3D structure R P (Figure 2 b), which is completely different from W W . Increasing the concentration of the heptamer solution resulted in larger assembled structures (e.g., a heptamer concentration of 4 mg mL À1 resulted in structures with widths of ca.…”

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confidence: 98%

Unprecedented Molecular Architectures by the Controlled Self‐Assembly of a β‐Peptide Foldamer

et al. 2010

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Nature utilizes the self-assembly of monomeric units by multiple noncovalent interactions for the construction of complex functional systems.[1] In recent decades, a variety of peptide-based scaffolds, which range from simple aromatic dipeptides to small protein fragments, have been studied in order to understand the underlying mechanism and mimic this process to create artificial nano-and microstructures. [2][3][4][5][6] Because of the intrinsic large conformational flexibility of short-length peptides, amphiphilic, [7,8] or cyclic [9] scaffolds have been typically employed to ensure the formation of welldefined self-assembled structures. However, in contrast to the morphologies found in inorganic nanostructures, [10] the morphologies of the peptide-based self-assembled nano-and microstructures are limited to round shapes such as spheres, tubes, and rods.[11] The ability to construct biocompatible peptide-based molecular architectures with anisotropic shapes should expand the possibilities for the design of molecular machines for diverse applications in biological and materials science.[12] Such a construction should be possible if a molecular design principle for monomeric units held together by comparable intermolecular interactions in three orthogonal directions was available; however, currently this is not the case. [13] On the other hand, b peptides (oligomers of b amino acids) are excellent artificial peptides that can mimic proteinlike secondary structures such as helices, strands, and turns. [14] The self-associating behavior of b peptides have recently been investigated, [15][16][17][18] but the construction of higher-order structures with specific morphologies is still in its infancy. Herein we report the first example of highly homogeneous, welldefined, and finite molecular architectures formed by the selfassembly of a helical b peptide in aqueous solution. The 3D shapes of the assembled nano-and microstructures can be controlled by simply changing the experimental conditions.We used a homo-oligomer of trans-(S,S)-2-aminocyclopentanecarboxylic acid (ACPC) as a building block for the self-assembly. This particular b peptide resembles an a-helical peptide in terms of handedness, helical pitch, and the direction of the macrodipole moment, but is known to adopt a more stable and unique helical conformation through intramolecular 12-membered hydrogen bonding between C=O (i) and NÀH (i + 3) (the so-called 12-helix) in both solid state and solution, if the number of monomers exceeds approximately six residues (Figure 1 a). [19] Figure 1 b shows the chemical structure of the ACPC heptamer (ACPC 7 ), which is a highly hydrophobic molecule (aspect ratio % 2), because the methylene units of the cyclopentane rings are displayed over the helical faces, and both the N-and Ctermini are protected by a tert-butyloxycarbonyl (Boc) and a benzyl group, respectively. The possible modes of selfassembly of ACPC oligomers are illustrated in Figure 1 c. With this simple design, ACPC 7 should adopt a stable righthanded 12-heli...

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confidence: 98%

Unprecedented Molecular Architectures by the Controlled Self‐Assembly of a β‐Peptide Foldamer

et al. 2010

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“…For example, Zhang et al. found that 2,5,8,11‐tetra‐tert‐butylperylene (TBPe) molecules form both normal cubes and truncated cubes in a surfactant (P123) solution …”

Section: Non‐templated Synthesismentioning

confidence: 99%

Anisotropic Colloids: From Non‐Templated to Patchy Templated Synthesis

Liu

Zhao

2018

Chemistry A European J

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Self-assembly of colloidal particles is an important and challenging way to generate novel colloidal superstructures for new materials. Recent progress on syntheses of anisotropic colloids highlights opportunities for such self-assembly, particularly in defining new non-cubic superstructures. Both non-templated and templated synthesis play an important role in preparing anisotropic colloidal particles. In this article, we briefly summarize recent progress in anisotropic colloids by non-templated and conventional templated synthesis, and introduce a conceptual strategy of "patchy templated synthesis" that differs from the conventional approach. We illustrate this strategy with recent examples emanating from colloidal rings, and discuss the future opportunities with this strategy for the synthesis of other anisotropic colloids.

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“…This principle also applies to the assembly of foldectures. Several studies on surfactant‐assisted synthesis of organic crystals, including one of our recent studies, attributed 3D shape selection to the facet‐specific adhesion of surfactant molecules and anisotropic passivation effect ,. However, the inherent dynamic nature of surfactant molecules hinders a clear rationalization of 3D shape evolution and the corresponding assembly mechanisms .…”

Section: Introductionmentioning

confidence: 97%

Self‐Assembly of a β‐Peptide Foldamer: The Role of the Surfactant in Three‐Dimensional Shape Selection

et al. 2019

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The effect of a small ionic surfactant, cetyltrimethylammonium bromide (CTAB), on the self‐assembly of a β‐peptide has been systematically studied by using scanning electron microscopy, X‐ray diffraction, selected area electron diffraction, and molecular dynamics (MD) simulations. The latter study suggested that the formation of asymmetric microcrystals may be due to the preferential adsorption of CTAB on {011} and (001) crystal faces. This work provides a plausible rationale for the characteristic 3D morphogenesis of foldectures and elucidates the interaction between the surfactant and organic building block molecules.

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Polyhedral Organic Microcrystals: From Cubes to Rhombic Dodecahedra

Cited by 31 publications

References 29 publications

Unprecedented Molecular Architectures by the Controlled Self‐Assembly of a β‐Peptide Foldamer

Unprecedented Molecular Architectures by the Controlled Self‐Assembly of a β‐Peptide Foldamer

Anisotropic Colloids: From Non‐Templated to Patchy Templated Synthesis

Self‐Assembly of a β‐Peptide Foldamer: The Role of the Surfactant in Three‐Dimensional Shape Selection

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