Polyhydramnios and fetal intrauterine growth restriction: ominous combination.

Sickler, G K; Nyberg, David A.; Sohaey, Roya; Luthy, David A.

doi:10.7863/jum.1997.16.9.609

Cited by 44 publications

(42 citation statements)

References 7 publications

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“…One report presented 22.2% chromosome abnormalities among women with polyhydramnios (Zahn et al 1993). Another report presented 38.5% chromosome abnormalities among women with polyhydramnios together with fetal growth restriction (Sickler et al 1997). These frequencies in Western countries are comparable to our results in the Japanese population.…”

Section: Discussionsupporting

confidence: 90%

Specific ultrasound findings associated with fetal chromosome abnormalities

Shimada

Yamada

Hoshi

et al. 2009

Congenital Anomalies

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Cytogenetic amniocentesis (CA) has been performed as a reliable prenatal diagnostic method for decades. The aims of the present study were to reveal the frequency of fetal chromosome abnormalities according to medical indications of CA, and to assess the risks of specific abnormal ultrasound findings. Data on chromosome karyotypes of fetuses from 5043 Japanese mothers were collected. Group I comprised 4626 fetuses whose mothers underwent CA due to a variety of parental reasons. Group II comprised 417 fetuses whose mothers underwent CA due to fetal abnormality, abnormality of amniotic fluid volume and fetal growth restriction. The frequency of chromosome abnormalities in Group II (17.7%) was significantly higher than in Group I (1.8%). The frequencies of chromosome abnormalities in Group II singleton fetuses with fetal abnormality, polyhydramnios and fetal growth restriction were 21.5, 22.9 and 19.6%, respectively. By multivariate analyses, we found that cystic hygroma (odds ratio 5.6, 95% CI 2.7-11.6), abnormal extremity (5.0, 1.7-14.4) and cardiovascular abnormality (3.3, 1.1-10.1) were significant variants associated with fetal chromosomal abnormalities. Information revealed in the present study constitutes a beneficial reference for genetic counseling.

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Section: Discussionsupporting

confidence: 90%

Specific ultrasound findings associated with fetal chromosome abnormalities

Shimada

Yamada

Hoshi

et al. 2009

Congenital Anomalies

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“…Some of these ®ndings include: intrauterine growth retardation (IUGR) (Salihu et al, 1997;Nyberg et al, 1993;Twining et al, 1993); abnormal growth, as measured by the biparietal diameter and femur length ratio (Benattar et al, 1999); Seoud et al, 1994;Dicke and Crane, 1991;(Ginsberg et al, 1990); choroid plexus cysts (Reinsch, 1997;Donnenfeld, 1995;Nadel et al, 1992;Platt et al, 1991;Fitzsimmons et al, 1989;Ostlere et al, 1989;Chitkara et al, 1988); abnormal positioning of ®ngers and clenched hand (Quintero et al, 1999); cardiac abnormalities (Gembruch et al, 1997;Paladini et al, 1993;Wladimiroff et al, 1989); echogenic bowel (Sipes et al, 1994;Scioscia et al, 1992); and facial and head abnormalities (Nicolaides et al, 1992a(Nicolaides et al, ,b,1993Benacerraf et al, 1986). Other unusual ®ndings with more uncertain implications include cystic hygroma (Shields et al, 1998); nuchal thickening (Nyberg et al, 1993); single umbilical artery (Sener et al, 1997); and polyhydramnios (Sickler et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Prenatal ultrasound findings in affected and unaffected pregnancies that are screen-positive for trisomy 18: the California experience

et al. 2000

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This study investigated whether significant differences in ultrasound findings exist between trisomy 18 affected and unaffected pregnancies positive by serum screening. Ultrasound reports were reviewed for 335 screen-positive women. This represented 65% of all trisomy 18 screen-positive patients who had follow-up services at any of 117 Californian state-approved Prenatal Diagnosis Centers during a six-month period from November 1, 1995 to April 30, 1996. Ultrasound reports were available for 100% of trisomy 18 fetuses diagnosed during the six month period (n=23). Ultrasound findings were reported as normal in 35% of the fetuses affected with trisomy 18. The number and type of abnormalities observed in the affected and unaffected groups are described. When compared to unaffected cases, the trisomy 18 affected fetuses had a greater re-dating discrepancy on follow-up ultrasound evaluation and significantly lower femur length to biparietal diameter (FL/BPD) ratio measurements. We recommend that all women who are screen positive for trisomy 18 be encouraged to have amniocentesis, regardless of ultrasound findings, since affected fetuses may not be detected otherwise.

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“…Specifically, our study inclusion criteria required the combination of severe IUGR and oligohydramnios which, when seen together in combination with an abnormal flow in the umbilical artery, may implicate the presence of thrombophilia. Notably, Sickler et al 18 showed that early IUGR associated with polyhydramnios was a very strong predictor for major anomalies and aneuploidy.…”

Section: Discussionmentioning

confidence: 99%

Mid-trimester severe intrauterine growth restriction is associated with a high prevalence of thrombophilia

Kupferminc

2002

BJOG: An International Journal of Obstetrics and Gynaecology

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Objective To investigate the association between severe mid-trimester IUGR, whose causes are unknown in most cases, and maternal thrombophilias. Design Case -control study.Setting Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, The Sackler Faculty of Medicine, Tel Aviv University. Population Twenty-six women with severe mid-trimester (22 -26 weeks of gestation) IUGR (birthweight <3rd centile) and 52 matched multiparous women with normal pregnancies (controls).Methods After excluding pregnancies with vascular maternal disease, chromosomal and structural aberrations and cytomegalovirus infection, 26 women out of 35 with severe mid-trimester IUGR remained and composed the study group. Each was matched for age, ethnicity and smoking status with two healthy women who had normal pregnancies. All the women were tested for genetic and acquired thrombophilias at least eight weeks after delivery. Main outcome measures Prevalence of maternal thrombophilias.Results The frequency of thrombophilias was 69% in the study group compared with 14% in the control group [odds ratio (OR) 4.5; 95% confidence interval (CI) 2.3-9, P < 0.001]. The frequencies of factor V Leiden mutation, prothrombin gene mutation and protein S deficiency were significantly increased in the study group compared with the control group. The frequency of multiple thrombophilias was 33% in the study group versus none among the controls. Of the 26 pregnancies with severe mid-trimester IUGR, 13 ended in intrauterine fetal death before 25 weeks of gestation: 10 of these women had thrombophilia. Conclusion Women with mid-trimester severe IUGR have an increased prevalence of inherited and acquired thrombophilias.

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Polyhydramnios and fetal intrauterine growth restriction: ominous combination.

Cited by 44 publications

References 7 publications

Specific ultrasound findings associated with fetal chromosome abnormalities

Specific ultrasound findings associated with fetal chromosome abnormalities

Prenatal ultrasound findings in affected and unaffected pregnancies that are screen-positive for trisomy 18: the California experience

Mid-trimester severe intrauterine growth restriction is associated with a high prevalence of thrombophilia

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