Polyhydroxy Fullerenes for Non‐Invasive Cancer Imaging and Therapy

Krishna, Vijay; Singh, Amit; Sharma, Prashant; Iwakuma, Nobutaka; Wang, Qiang; Zhang, Qizhi; Knapik, Jacquelyn A.; Jiang, Huabei; Grobmyer, Stephen R.; Koopman, Ben; Moudgil, Brij M.

doi:10.1002/smll.201000847

Cited by 96 publications

(61 citation statements)

References 30 publications

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“…Photothermal ablation is an exciting noninvasive cancer paradigm, [1][2][3][4][5] which is just beginning to enter the clinical arena for human cancer therapy. 6 Numerous nanomaterials including nanoshells, 1,2 polyhydroxy fullerenes, 5 gold speckled silica nanoparticles (NPs), 7 gold NPs, 8 gold nanorods, 3 nanotubes, 9,10 nanocages, 11 and quantum dots 12 have been investigated as anticancer photothermal agents.…”

Section: Introductionmentioning

confidence: 99%

“…6 Numerous nanomaterials including nanoshells, 1,2 polyhydroxy fullerenes, 5 gold speckled silica nanoparticles (NPs), 7 gold NPs, 8 gold nanorods, 3 nanotubes, 9,10 nanocages, 11 and quantum dots 12 have been investigated as anticancer photothermal agents. Numerous studies have demonstrated the efficacy of these nanomaterials for tumor ablation in vitro.…”

Section: Introductionmentioning

confidence: 99%

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Fractionated photothermal antitumor therapy with multidye nanoparticles

Gutwein¹,

Singh²,

Hahn³

et al. 2012

IJN

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Purpose: Photothermal therapy is an emerging cancer treatment paradigm which involves highly localized heating and killing of tumor cells, due to the presence of nanomaterials that can strongly absorb near-infrared (NIR) light. In addition to having deep penetration depths in tissue, NIR light is innocuous to normal cells. Little is known currently about the fate of nanomaterials post photothermal ablation and the implications thereof. The purpose of this investigation was to define the intratumoral fate of nanoparticles (NPs) after photothermal therapy in vivo and characterize the use of novel multidye theranostic NPs (MDT-NPs) for fractionated photothermal antitumor therapy. Methods: The photothermal and fluorescent properties of MDT-NPs were first characterized. To investigate the fate of nanomaterials following photothermal ablation in vivo, novel MDTNPs and a murine mammary tumor model were used. Intratumoral injection of MDT-NPs and real-time fluorescence imaging before and after fractionated photothermal therapy was performed to study the intratumoral fate of MDT-NPs. Gross tumor and histological changes were made comparing MDT-NP treated and control tumor-bearing mice. Results: The dual dye-loaded mesoporous NPs (ie, MDT-NPs; circa 100 nm) retained both their NIR absorbing and NIR fluorescent capabilities after photoactivation. In vivo MDT-NPs remained localized in the intratumoral position after photothermal ablation. With fractionated photothermal therapy, there was significant treatment effect observed macroscopically (P = 0.026) in experimental tumor-bearing mice compared to control treated tumor-bearing mice. Conclusion: Fractionated photothermal therapy for cancer represents a new therapeutic paradigm enabled by the application of novel functional nanomaterials. MDT-NPs may advance clinical treatment of cancer by enabling fractionated real-time image guided photothermal therapy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fractionated photothermal antitumor therapy with multidye nanoparticles

Gutwein¹,

Singh²,

Hahn³

et al. 2012

IJN

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“…Tumours injected with fullerenols were imaged using photoacoustic tomography and photothermally treated with a near-IR laser. As a result, the tumour size decreased by 72% within two hours of treatment and only a blister was visible after 20 h. 323,324 Theranostic tools on the basis of EMFs can be developed with relative ease. For example, a conjugate of a derivative of the EMF Gd@C 82 , namely, Gd@C 82 O 6 (OH) 16 (NHCH 2 CH 2 COOH) 8 , with the antibody of GFP (anti-GFP) presents a model for tumourtargeted imaging contrast agent based on EMFs.…”

Section: Iii3 Biomedical Applicationsmentioning

confidence: 99%

Fullerene derivatives as nano-additives in polymer composites

Penkova¹,

Acquah²,

Piotrovskiy³

et al. 2017

Russ. Chem. Rev.

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“…Since then, much research has been devoted to studies on the antioxidant (Dugan et al, 1996;Djordjevic et al, 2004;Bogdanovic et al, 2008), antimicrobial (Aoshima et al, 2009), anti-cancer (Chaudhuri et al, 2009Krishna et al, 2010), antitumor, and antimetastatic activities of medium-degree fullerenols (Jiao et al, 2010).…”

Section: Biochemical Applicationmentioning

confidence: 99%

Water-Soluble Single-Nano Carbon Particles: Fullerenol and Its Derivatives

Kokubo¹

2012

The Delivery of Nanoparticles

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Polyhydroxy Fullerenes for Non‐Invasive Cancer Imaging and Therapy

Cited by 96 publications

References 30 publications

Fractionated photothermal antitumor therapy with multidye nanoparticles

Fractionated photothermal antitumor therapy with multidye nanoparticles

Fullerene derivatives as nano-additives in polymer composites

Water-Soluble Single-Nano Carbon Particles: Fullerenol and Its Derivatives

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