Polyhydroxyalkanoates, the bioplastics of microbial origin: Properties, biochemical synthesis, and their applications

Behera, Shivananda; Priyadarshanee, Monika; Vandana, .; Das, Surajit

doi:10.1016/j.chemosphere.2022.133723

Cited by 64 publications

(19 citation statements)

References 177 publications

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“…Among various PHA, PHB has been widely used as a promising alternative to antibiotics and inefficient soluble SCFAs. As mentioned before, it is an intracellular, nontoxic, biodegradable biopolymer of C4 hydroxy-butyric fatty acid, belonging to SCL-PHA. ,, The uptake of PHB is more efficient than soluble SCFAs for filter-feeding animals because PHB is insoluble and can be converted into soluble 3-HB and butyrate in the animal gut . Recent studies have reported that PHB can act as a biocontrol agent , and an immunostimulant. ,,,, PHB-supplemented tilapia can achieve an 85% survival rate, similar to the survival rate achieved using common oxytetracycline antibiotics .…”

Section: Pha Application In Aquaculturementioning

confidence: 99%

“…As mentioned before, it is an intracellular, nontoxic, biodegradable biopolymer of C4 hydroxy-butyric fatty acid, belonging to SCL-PHA. 11,113,148 The uptake of PHB is more efficient than soluble SCFAs for filter-feeding animals because PHB is insoluble and can be converted into soluble 3-HB and butyrate in the animal gut. 10 Recent studies have reported that PHB can act as a biocontrol agent 31,78 and an immunostimulant.…”

Section: Phb As a Promising Biocontrol Agent Inmentioning

confidence: 99%

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Polyhydroxyalkanoates for Sustainable Aquaculture: A Review of Recent Advancements, Challenges, and Future Directions

Asiri

2024

J. Agric. Food Chem.

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Polyhydroxyalkanoates (PHA) are biodegradable biopolymers produced by prokaryotic microbes, which, at the same time, can be applied as single-cell proteins (SCPs), growing on renewable waste-derived substrates. These PHA polymers have gained increasing attention as a sustainable alternative to conventional plastics. One promising application of PHA and PHA-rich SCPs lies within the aquaculture food industry, where they hold potential as feed additives, biocontrol agents against diseases, and immunostimulants. Nevertheless, the cost of PHA production and application remains high, partly due to expensive substrates for cultivating PHA-accumulating SCPs, costly sterilization, energy-intensive SCPs harvesting techniques, and toxic PHA extraction and purification processes. This review summarizes the current state of PHA production and its application in aquaculture. The structure and classification of PHA, microbial sources, cultivation substrates, biosynthesis pathways, and the production challenges and solutions are discussed. Next, the potential of PHA application in aquaculture is explored, focusing on aquaculture challenges, common and innovative PHA-integrated farming practices, and PHA mechanisms in inhibiting pathogens, enhancing the immune system, and improving growth and gut health of various aquatic species. Finally, challenges and future research needs for PHA production and application in aquaculture are identified. Overall, this review paper provides a comprehensive overview of the potential of PHA in aquaculture and highlights the need for further research in this area.

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Section: Pha Application In Aquaculturementioning

confidence: 99%

Section: Phb As a Promising Biocontrol Agent Inmentioning

confidence: 99%

Polyhydroxyalkanoates for Sustainable Aquaculture: A Review of Recent Advancements, Challenges, and Future Directions

Asiri

2024

J. Agric. Food Chem.

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“…Several new developments in nanocellulose-based materials are being investigated in recent years, including 3D printing (Filiz et al, 2021;Mahendiran et al, 2021). Because of their biocompatibility, poly-hydroxyalkanoates are also used for other medical applications like post-surgical ulcer therapy, wound healing dressings, detection of cancer, heart valves, artificial blood arteries, and bone tissue engineering, etc (Iolanda et al, 2021;Li & Singh, 2021;Behera et al, 2022;Wu et al, 2022).…”

Section: Medical Applicationsmentioning

confidence: 99%

Bioplastic Production from Microalgae and their Applications- A Critical Review

Ranganadhareddy¹,

Ponnam²,

Chandrsekhar³

2022

J Biochem Technol

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“…A copolymer containing a 5.9% mol fraction of 3HHx exhibited the highest flexibility (163% elongation at break). Likewise, Young's modulus (631.3 MPa) and the maximum result for tensile strength (25.7 MPa) were attained when 2.5% was the mol fraction of 3Hx units in the copolymer (Behera et al, 2022). To analyze the mechanical properties, scaffolds and biopolymeric films were produced by the usage of mixtures of P (3HB) and P (3HB-co-3HHx) in another study (Ansari, 2019).…”

Section: Pha Propertiesmentioning

confidence: 99%

Polyhydroxyalkanoates, the Biopolymers of Microbial Origin- A Review

Ranganadhareddy¹,

Chandrsekhar²

2022

J Biochem Technol

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Because petroleum-based plastics are not biodegradable, as well as the energy they require in their production, the rising plastic substantially contributes to the depletion of the environment. In contrast to synthetic plastics, polyhydroxyalkanoates (PHAs) are sustainable and eco-friendly bioplastics. A variety of microorganisms, such as fungi, bacteria, and algae, can be used to entirely synthesize PHAs. Enhanced biodegradability, biocompatibility, as well as other mechano-chemical properties are some of the promising properties of value-added biopolymers. It was also shown that PHA polymers have different properties depending on their chemical composition (units of monomer) and substrates. As an alternative to petroleum-based polymers, PHAs have great promise and need further study to determine how to economically produce and utilize them. Various applications of microbially synthesized PHAs are described in the review. Several microbial groups have also been shown to synthesize these biopolymers by genetic regulation. Also revealed in this review are the potential biomedical, environmental, and industrial applications of this biopolymer.

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Polyhydroxyalkanoates, the bioplastics of microbial origin: Properties, biochemical synthesis, and their applications

Cited by 64 publications

References 177 publications

Polyhydroxyalkanoates for Sustainable Aquaculture: A Review of Recent Advancements, Challenges, and Future Directions

Polyhydroxyalkanoates for Sustainable Aquaculture: A Review of Recent Advancements, Challenges, and Future Directions

Bioplastic Production from Microalgae and their Applications- A Critical Review

Polyhydroxyalkanoates, the Biopolymers of Microbial Origin- A Review

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