Polyhydroxybutyrate production from marine source and its application

Kavitha, G.; Rengasamy, Ramasamy; Inbakandan, D.

doi:10.1016/j.ijbiomac.2017.12.155

Cited by 74 publications

(40 citation statements)

References 73 publications

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“…PHA, polyoxoesters of hydroxyalkanoates, are typical prokaryotic reserve materials; they are produced as intracellular products of the secondary metabolism of various Gram-negative or Gram-positive bacteria and several extremophilic Archaea. Here, a currently emerging trend is the isolation of novel halophilic microbial species of marine origin, which often display powerful PHA producers based on the conversion of inexpensive substrates [3][4][5][6]. Stored in the cell's cytoplasm, spherical in shape and light-refractive, PHA granules consist of an hydrophobic core of coiled PHA chains and water acting as plasticizer; this core is covered by more hydrophilic enzymes and structural proteins, which, as not yet definitively clarified, may form a protein membrane.…”

Section: Introductionmentioning

confidence: 99%

A Review on Established and Emerging Fermentation Schemes for Microbial Production of Polyhydroxyalkanoate (PHA) Biopolyesters

Koller

2018

Fermentation

152

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Polyhydroxyalkanoates (PHA) are microbial biopolyesters utilized as "green plastics". Their production under controlled conditions resorts to bioreactors operated in different modes. Because PHA biosynthesis constitutes a multiphase process, both feeding strategy and bioreactor operation mode need smart adaptation. Traditional PHA production setups based on batch, repeated batch, fed-batch or cyclic fed-batch processes are often limited in productivity, or display insufficient controllability of polyester composition. For highly diluted substrate streams like is the case of (agro) industrial waste streams, fed-batch enhanced by cell recycling has recently been reported as a viable tool to increase volumetric productivity. As an emerging trend, continuous fermentation processes in single-, two-and multi-stage setups are reported, which bring the kinetics of both microbial growth and PHA accumulation into agreement with process engineering and allow tailoring PHA's molecular structure. Moreover, we currently witness an increasing number of CO 2-based PHA production processes using cyanobacteria; these light-driven processes resort to photobioreactors similar to those used for microalgae cultivation and can be operated both discontinuously and continuously. This development is parallel to the emerging use of methane and syngas as abundantly available gaseous substrates, which also calls for bioreactor systems with optimized gas transfer. The review sheds light on the challenges of diverse PHA production processes in different bioreactor types and operational regimes using miscellaneous microbial production strains such as extremophilic Archaea, chemoheterotrophic eubacteria and phototrophic cyanobacteria. Particular emphasis is dedicated to the limitations and promises of different bioreactor-strain combinations and to efforts devoted to upscaling these processes to industrially relevant scales.

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Section: Introductionmentioning

confidence: 99%

A Review on Established and Emerging Fermentation Schemes for Microbial Production of Polyhydroxyalkanoate (PHA) Biopolyesters

Koller

2018

Fermentation

152

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“…Because PHAs are by nature biodegradable, can be produced from renewable bioresources, and have material properties close to the conventional petroleum-derived plastics, the commercial production and market development are actively pursued by several companies amid the growing plastic waste crisis [ 14 – 15 ]. Vibrio are perhaps the first to be known as producers of PHAs among marine microbes [ 16 ], and are isolated predominantly for the screening of the PHA production [ 17 ]. Intriguingly, aquatic farmed animals fed with poly(3-hydroxybutyrate) showed a reduced mortality compared to those not fed when being exposed to pathogenic Vibrio species, suggesting the application of PHAs as a biocontrol agent [ 18 ].…”

Section: Resultsmentioning

confidence: 99%

Three new O-isocrotonyl-3-hydroxybutyric acid congeners produced by a sea anemone-derived marine bacterium of the genus Vibrio

Li¹,

Harunari²,

Zhou³

et al. 2020

Beilstein J. Org. Chem.

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Liquid cultures of Vibrio sp. SI9, isolated from the outer tissue of the sea anemone Radianthus crispus, was found to produce three new O-isocrotonyl-3-hydroxybutyric acid derivatives, O-isocrotonyl-3-hydroxypentanoic acid (1), O-isocrotonyl-3-hydroxyhexanoic acid (2), and O-(Z)-2-hexenoyl-3-hydroxybutyric acid (3), together with the known O-isocrotonyl-3-hydroxybutyric acid (4). The structures of 1–3 were established by NMR spectroscopy and mass spectrometry, coupled with anisotropy-based chiral analysis, revealing the same R-configuration for all congeners 1–4. The compounds 1–4 were weakly growth-inhibitory against a marine fish ulcer pathogenic bacterium, Tenacibaculum maritimum NBRC16015. Structural similarities among 1–4, the O-isocrotonylated 3-hydroxybutyrate oligomers 5, and microbial biopolymer polyhydroxyalkanoates (PHA) suggest the presence of a common biosynthetic machinery, and hence a possible dehydrative modification at the hydroxy terminus of PHA.

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“…Because PHAs are by nature biodegradable, can be produced from renewable bioresources, and have material properties close to the conventional petroleumderived plastics, commercial production and market development are actively pursued by several companies amid the growing plastic waste crisis [14,15]. Vibrio are perhaps the first to be known as producers of PHAs among marine microbes [16], and still be isolated predominantly in the screening of PHA productivity [17]. Intriguingly, aquatic farmed animals feeded with poly(3-hydroxybutyrate) showed reduced mortality than those not feeded upon challenge by pathogenic Vibrio species, suggesting the application of PHAs as a biocontrol agent [18].…”

Section: Resultsmentioning

confidence: 99%

Three new O-isocrotonyl-3-hydroxybutyric acid congeners produced by a sea anemone-derived marine bacterium of the genus Vibrio

Li¹,

Harunari²,

Zhou³

et al. 2020

Preprint

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Liquid cultures of Vibrio sp. SI9, isolated from outer tissue of sea anemone Radianthus crispus, was found to produce three new O-isocrotonyl-3-hydroxybutyric acid derivatives, O-isocrotonyl-3-hydroxypentanoic acid (1), O-isocrotonyl-3-hydroxyhexanoic acid (2), and O-(Z)-2-hexenoyl-3-hydroxybutyric acid (3), together with known O-isocrotonyl-3-hydroxybutyric acid (4). The structures of 1-3 were established by spectroscopic analyses of NMR and mass spectrometry coupled with anisotropy-based chiral analysis, revealing the same (R)-configurations for all congeners 1-4. Compounds 1-4 were weakly growth-inhibitory against a marine fish ulcer pathogenic bacterium, Tenacibaculum maritimum NBRC16015.

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Polyhydroxybutyrate production from marine source and its application

Cited by 74 publications

References 73 publications

A Review on Established and Emerging Fermentation Schemes for Microbial Production of Polyhydroxyalkanoate (PHA) Biopolyesters

A Review on Established and Emerging Fermentation Schemes for Microbial Production of Polyhydroxyalkanoate (PHA) Biopolyesters

Three new O-isocrotonyl-3-hydroxybutyric acid congeners produced by a sea anemone-derived marine bacterium of the genus Vibrio

Three new O-isocrotonyl-3-hydroxybutyric acid congeners produced by a sea anemone-derived marine bacterium of the genus Vibrio

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