Polyimide neural probe for chronic sensing of neural activity and micro-positioning

Smith, Courtney S.; Scott, D.; Kim, Min Hyuck; Sanford, Larry D.; Song, Kyo D.; Yoon, Hargsoon

doi:10.1117/12.2009844

Cited by 1 publication

(1 citation statement)

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“…Researchers are now developing flexible substrates that better match the mechanical properties of brain tissue, resulting in less severe foreign body reactions and reduced tissue damage from micromotion [23]. The development of polymer-based neural interfaces made of parylene [21], polyimide [20], SU8 [1], and Liquid Crystal Polymer [11] has led to a surge in the adoption of flexible neural interfaces, with major BCI companies like Neuralink [2], Precision Neuroscience, and Neuro-One Technologies making breakthrough commercial technologies. Flexible substrates also offer more precise and accurate recordings of long-term neural activity, and as the field advances, they have the potential to become the standard for invasive neural interfaces.…”

Section: Introductionmentioning

confidence: 99%

Polyimide-Based Flexible Multi-Electrode Arrays: Synthesis, Microfabrication, andin-vivoValidation

Kumar,

Deshpande,

Kalur

et al. 2023

Preprint

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Thin film neural microelectrodes are popularly being used in brain-computer interfaces and tools for neurosurgical interventions. Among the various thin films used, polyimide stands out as an excellent material for substrate passivation due to its chemical inertness, biocompatibility, mechanical flexibility, and superior dielectric properties. While polyimide is extensively used as a substrate in thin film neural interfaces, the lack of availability of a clinical-grade polyimide limits their use in human clinical applications. This paper presents a comprehensive solution by developing an ISO-10993-11-approved polyamic acid for fabricating thin-film polyimide microelectrodes. Benchtop tests and in-vivo experiments in anesthetized mice demonstrate the potential of this synthesized polyamic acid and microfabrication processes for commercialization in clinical settings, particularly for brain-computer interfaces and invasive neural microelectrodes.

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