Polyketide butenolide, diphenyl ether, and benzophenone derivatives from the fungus Aspergillus flavipes PJ03-11

Antibacterial Diphenyl Ether, Benzophenone and Xanthone Derivatives from Aspergillus flavipes

“…Aspergillus sp., as one genus of the most widely distributed fungi, produce a variety of bioactive secondary metabolites, such as antiviral xanthones, diphenyl ether and butenolide derivatives as α ‐glucosidase inhibitor, antimicrobial benzophenones and diphenyl ether, cytotoxic diphenyl derivatives . Chlorinated diphenyl ethers are chemical markers of Aspergillus sp., the biosynthesis of these compounds is generally considered to proceed from the anthraquinone emodin, via sulochrin, and the grisandienes such as geodin .…”

Natural Products Research in China From 2015 to 2016

“…The wetland mud-derived fungus Aspergillus flavipes PJ03-11 (Red Beach National Nature Reserve, Liaoning, China) produced three novel butenolides (Zhang et al, 2016f ) and three new phenalenone derivatives, flaviphenalenones A–C (Zhang et al, 2016e ). Aspulvinones P ( 168 ), Q ( 169 ), and methybutyrolactone III ( 170 ), as well as flaviphenalenones B ( 171 ) and C ( 172 ) showed more potent α-glucosidase inhibitory activities than acarbose (0.685 mM) with IC 50 values of 0.079, 0022, 0.016, 0.095, and 0.079 mM, respectively.…”

γ-Butyrolactones from Aspergillus Species: Structures, Biosynthesis, and Biological Activities

“…However, 57 showed only slight inhibitory activity with an IC 50 value of 200 µM in a microsomal glucose-6-phosphate activity assay [56]. It is noteworthy that 4, 71, and 72 showed stronger inhibitory activity on α-glucosidase with IC 50 values of 0.016, 0.079, and 0.022 M than acarbose (IC 50 0.685 M) [46].…”