Polylactic acid-based electrospun fiber and hyaluronic acid-valsartan hydrogel scaffold for chronic wound healing

Ilomuanya, Margaret O.; Okafor, Prosper S.; Amajuoyi, Joyce N.; Onyejekwe, John C.; Okubanjo, Omotunde; Adeosun, S. O.; Silva, Boladale O.

doi:10.1186/s43088-020-00057-9

Cited by 23 publications

(8 citation statements)

References 30 publications

(57 reference statements)

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“…It is a widely used polymer in nanofibers fabrication, which is obtained by polymerization of lactide for diabetic wound healing purposes [ 71 ]. It is usually crosslinked with other polymers, such as gelatin, to enhance its cell adhesion properties, or it is combined with biomaterials such as silver nanoparticles for wound dressing purposes to curb microbial growth in infected wounds [ 30 ].…”

Section: Polymers Used In the Fabrication Of Nanofibrous Scaffoldsmentioning

confidence: 99%

Nanofibrous Scaffolds for Diabetic Wound Healing

Aliyu

Adeleke

2023

Pharmaceutics

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Chronic wounds are one of the secondary health complications that develop in individuals who have poorly managed diabetes mellitus. This is often associated with delays in the wound healing process, resulting from long-term uncontrolled blood glucose levels. As such, an appropriate therapeutic approach would be maintaining blood glucose concentration within normal ranges, but this can be quite challenging to achieve. Consequently, diabetic ulcers usually require special medical care to prevent complications such as sepsis, amputation, and deformities, which often develop in these patients. Although several conventional wound dressings, such as hydrogels, gauze, films, and foams, are employed in the treatment of such chronic wounds, nanofibrous scaffolds have gained the attention of researchers because of their flexibility, ability to load a variety of bioactive compounds as single entities or combinations, and large surface area to volume ratio, which provides a biomimetic environment for cell proliferation relative to conventional dressings. Here, we present the current trends on the versatility of nanofibrous scaffolds as novel platforms for the incorporation of bioactive agents suitable for the enhancement of diabetic wound healing.

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Section: Polymers Used In the Fabrication Of Nanofibrous Scaffoldsmentioning

confidence: 99%

Nanofibrous Scaffolds for Diabetic Wound Healing

Aliyu

Adeleke

2023

Pharmaceutics

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“…The results of reepithelization study revealed that the PLA-valsartan-based hydrogel scaffold-treated groups showed 1.43-folds increase in reepithelialization rate as compared to neomycin-based dressings. In addition, PLA-valsartan-based hydrogel scaffold-treated groups exhibited 2.5-folds increase in wound closure as compared to neomycin-based dressing-treated groups [ 168 ].…”

Section: Materials Used In Scaffold Fabricationmentioning

confidence: 99%

Recent Progress in Development of Dressings Used for Diabetic Wounds with Special Emphasis on Scaffolds

Awasthi

Gulati

Kumar

et al. 2022

BioMed Research International

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Diabetic wound (DW) is a secondary application of uncontrolled diabetes and affects about 42.2% of diabetics. If the disease is left untreated/uncontrolled, then it may further lead to amputation of organs. In recent years, huge research has been done in the area of wound dressing to have a better maintenance of DW. These include gauze, films, foams or, hydrocolloid-based dressings as well as polysaccharide- and polymer-based dressings. In recent years, scaffolds have played major role as biomaterial for wound dressing due to its tissue regeneration properties as well as fluid absorption capacity. These are three-dimensional polymeric structures formed from polymers that help in tissue rejuvenation. These offer a large surface area to volume ratio to allow cell adhesion and exudate absorbing capacity and antibacterial properties. They also offer a better retention as well as sustained release of drugs that are directly impregnated to the scaffolds or the ones that are loaded in nanocarriers that are impregnated onto scaffolds. The present review comprehensively describes the pathogenesis of DW, various dressings that are used so far for DW, the limitation of currently used wound dressings, role of scaffolds in topical delivery of drugs, materials used for scaffold fabrication, and application of various polymer-based scaffolds for treating DW.

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“…PLA-based electrospun fibers loaded with hyaluronic acid-valsartan hydrogels have been shown to be stable and possess proven diabetic wound healing property. This was as a result of the known biomimetic effect of the fibers and increased reepithelization facilitated by the hydrogels containing angiotensin inhibitors which is facilitated by the presence of hyaluronic acid as the ECM components [43].…”

Section: Elastin and Fibronectinmentioning

confidence: 99%

Polymeric Biomaterials for Wound Healing Incorporating Plant Extracts and Extracellular Matrix Components

Ilomuanya¹,

Cardoso-Daodu²,

Ubani-Ukoma³

et al. 2022

Recent Advances in Wound Healing

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Biomaterials are constructed to promote or stimulate the processes of wound healing. Polymeric biomaterials can be used to hydrate the wound and serve as barrier to pathogens with plant extracts, antimicrobial agents and extracellular components incorporated to stimulate the healing process. The biological and physical augmentation provided by extracellular matrix derived implants continues facilitate innovation in biomaterials utilized in management of nonhealing wounds. Tissue-processing methodologies can birth extracellular matrix-based devices with characteristic post-implantation responses ranging from the classic foreign body encapsulation of a permanent implant, to one where the implant is degraded and resorbed, to one where the processed extracellular matrix implant is populated by local fibroblasts and supporting vasculature to produce, a viable and metabolically active tissue. Extracellular matrix components and plant extracts have been shown to possesses pharmacological properties with potential for use in the treatment of skin diseases and wound healing. Antioxidant, anti-inflammatory assays, and wound healing assays have been shown to support the dermatological and wound healing usage of these medicinal plants extracts.

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Polylactic acid-based electrospun fiber and hyaluronic acid-valsartan hydrogel scaffold for chronic wound healing

Cited by 23 publications

References 30 publications

Nanofibrous Scaffolds for Diabetic Wound Healing

Nanofibrous Scaffolds for Diabetic Wound Healing

Recent Progress in Development of Dressings Used for Diabetic Wounds with Special Emphasis on Scaffolds

Polymeric Biomaterials for Wound Healing Incorporating Plant Extracts and Extracellular Matrix Components

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