Polylactic Acid Based Nanocomposites: Promising Safe and Biodegradable Materials in Biomedical Field

Sha, Lili; Chen, Zhaofeng; Zhou, Chen; Zhang, Aili; Yang, Zhaogang

doi:10.1155/2016/6869154

Cited by 105 publications

(52 citation statements)

References 120 publications

(127 reference statements)

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“…Depending on the composition of the optically active l - and d , l -enantiomers, PLA can crystallize in three forms (α, β, and γ). Thorough understanding of the intrinsic structural, thermal, and physicochemical properties of PLA polymers along with the knowledge of how such properties can be tuned and manipulated with nanomaterials have fueled remarkable biotechnological interest in PLA nanocomposites [ 4 , 5 , 6 ]. The extensive review by Södergårt and Stold [ 7 ] presents different polymerization schemes associated with lactic acid chemistry.…”

Section: Introductionmentioning

confidence: 99%

Thermomechanical Properties of Polylactic Acid-Graphene Composites: A State-of-the-Art Review for Biomedical Applications

Bayer

2017

Materials

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Due to its biodegradable and bioabsorbable characteristics polylactic acid (PLA) has attracted considerable attention for numerous biomedical applications. Moreover, a number of tissue engineering problems for function restoration of impaired tissues have been addressed by using PLA and its copolymers due to their biocompatibility and distinctive mechanical properties. Recent studies on various stereocomplex formation between enantiomeric PLA, poly(l-lactide) (PLLA) and poly(d-lactide) (PDLA) indicated that stereocomplexation enhances the mechanical properties as well as the thermal- and hydrolysis-resistance of PLA polymers. On the other hand, biomedical application of graphene is a relatively new front with significant potential. Many recent reports have indicated that understanding of graphene-cell (or tissue, organ) interactions; particularly the cellular uptake mechanisms are still challenging. Therefore, use of graphene or graphene oxide properly embedded in suitable PLA matrices can positively impact and accelerate the growth, differentiation, and proliferation of stem cells, conceivably minimizing concerns over cytotoxicity of graphene. As such, PLA-graphene composites hold great promise in tissue engineering, regenerative medicine, and in other biomedical fields. However, since PLA is classified as a hard bio-polyester prone to hydrolysis, understanding and engineering of thermo-mechanical properties of PLA-graphene composites are very crucial for such cutting-edge applications. Hence, this review aims to present an overview of current advances in the preparation and applications of PLA-graphene composites and their properties with focus on various biomedical uses such as scaffolds, drug delivery, cancer therapy, and biological imaging, together with a brief discussion on the challenges and perspectives for future research in this field.

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Section: Introductionmentioning

confidence: 99%

Thermomechanical Properties of Polylactic Acid-Graphene Composites: A State-of-the-Art Review for Biomedical Applications

Bayer

2017

Materials

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“…Due to their good biocompatibility, the PLA-based materials were extensively used in the field of tissue engineering. However, in order to obtain better optimized scaffolds and to increase cell proliferation and cell adhesion on their surface, PLA have been mixed with other polymers, such as collagen, gelatin or graphene oxide [44,45]. For instance, Qiao et al [45] found that PLA/collagen electrospun fibrous scaffolds at a 60:40 weight ratio showed greatest stability, cell attachment, cell proliferation, and osteogenic differentiation of bone marrow stromal cells after five-week culture period.…”

Section: Discussionmentioning

confidence: 99%

Development of Bionanocomposites Based on PLA, Collagen and AgNPs and Characterization of Their Stability and In Vitro Biocompatibility

et al. 2020

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Bionanocomposites including poly(lactic acid) (PLA), collagen, and silver nanoparticles (AgNPs) were prepared as biocompatible and stable films. Thermal properties of the PLA-based bionanocomposites indicated an increase in the crystallinity of PLA plasticized due to a small quantity of AgNPs. The results on the stability study indicate the promising contribution of the AgNPs on the durability of PLA-based bionanocomposites. In vitro biocompatibility conducted on the mouse fibroblast cell line NCTC, clone 929, using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay showed high values of cell viability (>80%) after cell cultivation in the presence of bionanocomposite formulations for 48 h, while the percentages of lactate dehydrogenase (LDH) released in the culture medium were reduced (<15%), indicating no damages of the cell membranes. In addition, cell cycle analysis assessed by flow cytometry indicated that all tested bionanocomposites did not affect cell proliferation and maintained the normal growth rate of cells. The obtained results recommend the potential use of PLA-based bionanocomposites for biomedical coatings.

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“…Anti-adhesion materials, patch, drug-delivery carrier, bone-fixing device, suture, tissue-engineered scaffold [40][41][42] Biocompatibility, good mechanical properties, safe, non-toxic [40][41][42] Poor toughness, degradation speed slow, hydrophobicity, lack of reactive side chain groups [40][41][42] Polyurethane Excipients, medical bandage [43][44][45] Low cost, rich resource, good mechanical properties [43,44,46,47] Degradation speed slow [43,46,47] Poly(lactic-glycolic acid) (PLGA)…”

Section: Chitosanmentioning

confidence: 99%

Polymer-Based Nanomaterials and Applications for Vaccines and Drugs

et al. 2018

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Nanotechnology plays a significant role in drug development. As carriers, polymeric nanoparticles can deliver vaccine antigens, proteins, and drugs to the desired site of action. Polymeric nanoparticles with lower cytotoxicity can protect the delivered antigens or drugs from degradation under unfavorable conditions via a mucosal administration route; further, the uptake of nanoparticles by antigen-presenting cells can increase and induce potent immune responses. Additionally, nanomaterials are widely used in vaccine delivery systems because nanomaterials can make the vaccine antigen long-acting. This review focuses on some biodegradable polymer materials such as natural polymeric nanomaterials, chemically synthesized polymer materials, and biosynthesized polymeric materials, and points out the advantages and the direction of research on degradable polymeric materials. The application and future perspectives of polymeric materials as delivery carriers and vaccine adjuvants in the field of drugs and vaccines are presented. With the increase of knowledge and fundamental understandings of polymer-based nanomaterials, means of integrating some other attractive properties, such as slow release, target delivery, and alternative administration methods and delivery pathways are feasible. Polymer-based nanomaterials have great potential for the development of novel vaccines and drug systems for certain needs, including single-dose and needle-free deliveries of vaccine antigens and drugs in the future.

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Polylactic Acid Based Nanocomposites: Promising Safe and Biodegradable Materials in Biomedical Field

Cited by 105 publications

References 120 publications

Thermomechanical Properties of Polylactic Acid-Graphene Composites: A State-of-the-Art Review for Biomedical Applications

Thermomechanical Properties of Polylactic Acid-Graphene Composites: A State-of-the-Art Review for Biomedical Applications

Development of Bionanocomposites Based on PLA, Collagen and AgNPs and Characterization of Their Stability and In Vitro Biocompatibility

Polymer-Based Nanomaterials and Applications for Vaccines and Drugs

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