Polylactic Acid for Visualizing the Vitreous Body during Vitrectomy

Yamashita, Toshifumi; Sakamoto, Taiji; Yamakiri, Keita; Matsuda, Masayoshi; Enaida, Hiroshi; Ueno, Akifumi; Atsumi, Ikuyo; Matsuhisa, Keiichi; Sakamoto, Yuji; Kida, Tetsuo; Ishibashi, Tatsuro

doi:10.1167/iovs.06-1020

Cited by 5 publications

(5 citation statements)

References 13 publications

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“…In their reports, 11-deoxycortisol could visualize the vitreous as clearly as TA, with no adverse events such as IOP rise or corneal endothelial damage. Yamashita et al demonstrated polylactic acid for this purpose [117]. Polylactic acid is a biodegradable substance without any biological effects.…”

Section: Adverse Eventsmentioning

confidence: 99%

“…At the same time, PLA has been used in orthopedic surgery and has been reported to be safe [118]. PLA granules are originally white and adhere to the gel-like structure so easily that they assist in visualizing the transparent vitreous as do TA granules, but with no harmful consequences in rabbits and subhuman primates [117]. These two agents might be good alternatives if TA is proven to be intolerably harmful in the future.…”

Section: Adverse Eventsmentioning

confidence: 99%

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Visualizing vitreous in vitrectomy by triamcinolone

Sakamoto

Ishibashi

2009

Graefes Arch Clin Exp Ophthalmol

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Section: Adverse Eventsmentioning

confidence: 99%

Section: Adverse Eventsmentioning

confidence: 99%

Visualizing vitreous in vitrectomy by triamcinolone

Sakamoto

Ishibashi

2009

Graefes Arch Clin Exp Ophthalmol

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“…Diffuse residual vitreous cortex after surgical PVD was reported to be much more frequent in diabetic retinopathy than in other diseases,11–14 and TA was essential to observe it. On the other hand, an “island-like” residual vitreous cortex, termed premacular residual vitreous cortex, frequently was found to be left on the macula after PVD in non-diabetic eyes 12,13,20. The premacular residual vitreous cortex can provide a good scaffold for cell proliferation and extracellular matrix production, resulting in future macular pucker and epiretinal membranes 21.…”

Section: Discussionmentioning

confidence: 99%

Localized vitreous adhesion to the retina after ocular contusion with a baseball

Kimura¹,

Nishimura²,

Sugiyama³

2012

OPTH

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PurposeTo report a series of five cases of vitreous adhesions after blunt trauma caused by a baseball strike.MethodsThe medical records of patients with ocular contusion after being struck by a baseball, who had undergone pars plana vitrectomy, were reviewed. An aqueous suspension of triamcinolone acetonide was used intraoperatively to facilitate visualization of the vitreous.ResultsFive eyes were reviewed in this study. There were two cases of retinal detachment, two cases of traumatic macular hole, and one case of retinal detachment due to traumatic macular hole. Despite the surgical creation of posterior vitreous detachment, if not already present, the thin layer of localized vitreous adhesion to the retinal necrotic area with/without retinal hole was found between the major vascular arcades and the equator in all cases. The thin layer of the vitreous was removed with a vitreous cutter and diamond-dusted membrane scraper, but complete removal was impossible.ConclusionsA thin layer of localized vitreous adhesion at the area of retinal degeneration was observed in eyes following ocular contusion.

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“…In that study, upregulation of retinal GFAP, an indicator of vitrectomy-related retinal trauma, was also detected in vitrectomy-treated rabbit eyes. The majority of recent studies on retinal function following vitrectomy have been short-term toxicity or clearance experiments (37–39). Intravitreal injection of PBS, bacterial media, or vancomycin alone can cause a transient posterior segment inflammation that, in the rabbit eye, resolves within 4 h (data not shown).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Vitrectomy in Improving the Outcome of Bacillus Cereus Endophthalmitis

Callegan¹,

Guess²,

Wheatley³

et al. 2011

Retina

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Purpose To evaluate the efficacy of vitrectomy with vancomycin for the treatment of experimental Bacillus cereus endophthalmitis. Methods Endophthalmitis was initiated in rabbits via intravitreal injection of 100 CFU B. cereus. Treatment groups included included 25-gauge transconjunctival sutureless vitrectomy with intravitreal vancomycin (1 mg) or vancomycin alone. Groups were treated at 4 h, 5 h, or 6 h postinfection. At 48 h (for 4 h and 5 h groups) or 36 h (for the 6 h group) postinfection, eyes were analyzed by electroretinography, histology, and inflammatory cell counts. Results Treatment with vitrectomy/vancomycin at 4 h resulted in significantly greater retinal function compared to that of vancomycin alone. Intraocular inflammation following treatment at 4 h was minimal for both treatment groups. Treatment with vitrectomy/vancomycin or vancomycin alone at 5 h or 6 h postinfection resulted in similar levels of retinal function loss (i.e. >90%) and significant intraocular inflammation. Conclusions These results demonstrate that vitrectomy may be of therapeutic benefit in the treatment of B. cereus endophthalmitis, but only during the early stages of infection.

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Polylactic Acid for Visualizing the Vitreous Body during Vitrectomy

Abstract: PLA can be a new surgical adjuvant to visualize the vitreous body during vitrectomy.

Cited by 5 publications

References 13 publications

Visualizing vitreous in vitrectomy by triamcinolone

Visualizing vitreous in vitrectomy by triamcinolone

Localized vitreous adhesion to the retina after ocular contusion with a baseball

Efficacy of Vitrectomy in Improving the Outcome of Bacillus Cereus Endophthalmitis

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