Polylactic acid nanoparticles, a colloidal drug delivery system for lipophilic drugs

Krause, H.-J.; Schwarz, Annett; Rohdewald, Peter

doi:10.1016/0378-5173(85)90064-x

Cited by 94 publications

(29 citation statements)

References 19 publications

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“…Bazile et al (1992) indicated that PLA microspheres coated with albumin were not found to be successful in avoiding Kupffer cell sequestration: approximately 90% of the administrated dose was found in the liver. Krause et al (1985) also found that PLA nanoparticles accumulated predominantly in the liver after intravenous injection. Gref et al (1994) observed that increasing the molecular weight of the PEG component from 5 kDa to 20 kDa increased blood circulation times while decreasing liver uptake.…”

Section: Surface Coatingmentioning

confidence: 88%

Magnetically responsive microparticles for targeted drug and radionuclide delivery.

Kamiński¹,

Ghebremeskel²,

Núñez³

et al. 2004

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Section: Surface Coatingmentioning

confidence: 88%

Magnetically responsive microparticles for targeted drug and radionuclide delivery.

Kamiński¹,

Ghebremeskel²,

Núñez³

et al. 2004

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“…An example of this method is briefly described here. Polyester is dissolved in chloroform and this solution is mixed with an aqueous phase to form a uniform oil/water emulsion [154,155]. Continuous emulsification under mixing is necessary to prevent organic droplet coalescence and to allow spontaneous solvent evaporation and particle formation [104].…”

Section: Preparation Of Polymeric Nanoparticulate Drug Delivery Systemsmentioning

confidence: 99%

Nanoparticles for the Treatment ofAlzheimer's Disease: Theoretical Rationale, Present Status and Future Perspectives

Liu

Men

Perry

et al. 2003

Nanotechnologies for the Life Sciences

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The sections in this article are Introduction Rationales: The Ability of Nanoparticles to Cross the BBB – A Useful Tool to Deliver Drugs into the Brain Physiological Functions of the BBB Strategies for Drug BBB Penetration Preparation of Polymeric Nanoparticulate Drug Delivery Systems Possible Mechanisms by which Nanoparticles Cross the BBB Status: Nanoparticle Targeting Transport of Therapeutic Agents for Potential Treatment of AD Nanoparticle Targeting of A β to Deliver Potentially Therapeutic Agents Nanoparticulate Antioxidant Delivery to Increase Efficacy against A β‐mediated Oxidative Stress Nanoparticle Delivery of Copper Chelator for Preventing and Reversing A β Deposition Nanoparticle Transport of Iron Chelators and Metal Chelator Complexes Into and Out of the Brain, Respectively Increased Levels of Various Metals in the Brain of AD Patients Problems with Iron Chelators for Simultaneous Removal of Multimetal Ions for Treatment of AD Nanoparticle Transport Technology to Improve Chelation Therapy for AD Experimental Descriptions Results and Discussion Perspectives Acknowledgments

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“…Continuous emulsification under stirring prevents coalescence of the organic droplets and can be further improved by sonication or microfluidization. 1,[5][6][7][8] The emulsificationevaporation method is interesting for many reasons: the use of pharmaceutically acceptable organic solvents, high yields, good reproducibility, and easy scaling up. A further step has been achieved with the development of the emulsification-diffusion method described by Leroux et al 9 and Quintanar-Guerrero et al 10,11 This process involves (1) the mutual saturation of the organic and the aqueous phases prior to the emulsification, (2) the dispersion of a partially water-miscible solvent with the dissolved polymer into an aqueous phase containing a stabilizer, and (3) the addition of a large amount of pure water that provokes the diffusion of the solvent and the aggregation of the polymer as nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Preparation of surfactant-free nanoparticles of methacrylic acid copolymers used for film coating

et al. 2006

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The aim of the present study was to prepare surfactant-free pseudolatexes of various methacrylic acid copolymers. These aqueous colloidal dispersions of polymeric materials for oral administration are intended for film coating of solid dosage forms or for direct manufacturing of nanoparticles. Nanoparticulate dispersions were produced by an emulsificationdiffusion method involving the use of partially water-miscible solvents and the mutual saturation of the aqueous and organic phases prior to the emulsification in order to reduce the initial thermodynamic instability of the emulsion. Because of the self-emulsifying properties of the methacrylic acid copolymers, it was possible to prepare aqueous dispersions of colloidal size containing up to 30% wt/vol of Eudragit RL, RS, and E using 2-butanone or methyl acetate as partially watermiscible solvents, but without any surfactant. However, in the case of the cationic Eudragit E, protonation of the tertiary amine groups by acidification of the aqueous phase was necessary to improve the emulsion stability in the absence of surfactant and subsequently to prevent droplet coalescence during evaporation. In addition, a pseudolatex of Eudragit E was used to validate the coating properties of the formulation for solid dosage forms. Film-coated tablets of quinidine sulfate showed a transparent glossy continuous film that was firmly attached to the tablet. The dissolution profile of quinidine sulfate from the tablets coated with the Eudragit E pseudolatex was comparable to that of tablets coated with an acetonic solution of Eudragit E. Furthermore, both types of coating ensured similar taste masking. The emulsificationevaporation method used was shown to be appropriate for the preparation of surfactant-free colloidal dispersions of the 3 types of preformed methacrylic acid copolymers; the dispersions can subsequently be used for film coating of solid dosage forms.

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Polylactic acid nanoparticles, a colloidal drug delivery system for lipophilic drugs

Cited by 94 publications

References 19 publications

Magnetically responsive microparticles for targeted drug and radionuclide delivery.

Magnetically responsive microparticles for targeted drug and radionuclide delivery.

Nanoparticles for the Treatment ofAlzheimer's Disease: Theoretical Rationale, Present Status and Future Perspectives

Preparation of surfactant-free nanoparticles of methacrylic acid copolymers used for film coating

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