Polylactic acid/polyethylene glycol blend fibres prepared via melt electrospinning: effect of polyethylene glycol content

Nazari, Tayebe; Garmabi, Hamid

doi:10.1049/mnl.2013.0735

Cited by 18 publications

(11 citation statements)

References 35 publications

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“…1G and Table 2_SUP). These findings are in line with previous studies and suggest that PEG acts like a nucleating agent for PLA [33,34]. Furthermore, PEG has been shown to be a suitable plasticizer or impact modifier for PLA owing to its good miscibility with PLA [32,[35][36][37].…”

Section: Development and Characterisation Of Sbs Fibressupporting

confidence: 92%

Solution blow spinning fibres: New immunologically inert substrates for the analysis of cell adhesion and motility

et al. 2017

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The control of cell behaviour through material geometry is appealing as it avoids the requirement for complex chemical surface modifications. Significant advances in new technologies have been made to the development of polymeric biomaterials with controlled geometry and physico-chemical properties. Solution blow spinning technique has the advantage of ease of use allowing the production of nano or microfibres and the direct fibre deposition on any surface in situ. Yet, in spite of these advantages, very little is known about the influence of such fibres on biological functions such as immune response and cell migration. In this work, we engineered polymeric fibres composed of either pure poly(lactic acid) (PLA) or blends of PLA and polyethylene glycol (PEG) by solution blow spinning and determined their impact on dendritic cells, highly specialised cells essential for immunity and tolerance. We also determined the influence of fibres on cell adhesion and motility. Cells readily interacted with fibres resulting in an intimate contact characterised by accumulation of actin filaments and focal adhesion components at sites of cell-fibre interactions. Moreover, cells were guided along the fibres and actin and focal adhesion components showed a highly dynamic behaviour at cell-fibre interface. Remarkably, fibres did not elicit any substantial increase of activation markers and inflammatory cytokines in dendritic cells, which remained in their immature (inactive) state. Taken together, these findings will be useful for developing new biomaterials for applications in tissue engineering and regenerative medicine.

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Section: Development and Characterisation Of Sbs Fibressupporting

confidence: 92%

Solution blow spinning fibres: New immunologically inert substrates for the analysis of cell adhesion and motility

et al. 2017

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“…For melt electrospinning, a custom‐designed apparatus was used (Scheme ) which has been described elsewhere in detail …”

Section: Methodsmentioning

confidence: 99%

“…In this regard, we have previously succeeded in melt electrospinning of PLA into ultrafine fibers with a custom‐built device, by incorporating polyethylene glycol (PEG) as a viscosity reducing agent . It is notable that PEG, which is a hydrophilic semicrystalline and biodegradable polymer, is considered an effective plasticizer for PLA‐based systems .…”

Section: Introductionmentioning

confidence: 99%

The effects of processing parameters on the morphology of PLA/PEG melt electrospun fibers

Nazari

Garmabi

2017

Polymer International

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Electrospinning of a polymer melt is an ideal technique to produce highly porous nanofibrous or microfibrous scaffolds appropriate for biomedical applications. In recent decades, melt electrospinning has been known as an eco‐friendly procedure as it eliminates the cytotoxic effects of the solvents used in solution electrospinning. In this work, the effects of spinning conditions such as temperature, applied voltage, nozzle to collector distance and collector type as well as polyethylene glycol (PEG) concentration on the diameter of melt electrospun polylactic acid (PLA)/PEG fibers were studied. The thermal stability of PLA/PEG blends was monitored through TGA and rheometry. Morphological investigations were carried out via optical and scanning electron microscopy. Based on the results, blends were almost stable over the temperature range of melt electrospinning (170 − 230 °C) and a short spinning time of 5 min. To obtain non‐woven meshes with uniform fiber morphologies, experimental parameters were optimized using ANOVA. While increasing the temperature, applied voltage and PEG content resulted in thinner fibers, PEG concentration was the most influential factor on the fiber diameter. In addition, a nozzle to collector distance of 10 cm was found to be the most suitable for preparing uniform non‐woven PLA/PEG meshes. At higher PEG concentrations, alterations in the collector distance did not affect the uniformity of fibers, although at lower distances vigorous bending instabilities due to polarity augmentation and viscosity reduction resulted in curly fibrous meshes. Finally, the finest and submicron scale fibers were obtained through melt electrospinning of PLA/PEG (70/30) blend collected on a metallic frame. © 2017 Society of Chemical Industry

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“…which can lead to tailored properties in terms of mechanical response, biodegradation rate, etc. Another interesting approach is the use of environmentally friendly and non-toxic plasticizers such as poly(ethylene glycol), PEG [16][17][18], poly(propylene glycol), PPG [19], oligomeric lactic acid, OLA [20], citrates such as acetyl tributyl citrate (ATBC) [21][22][23] or tributyl citrate (TBC) [22,[24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Plasticizing effect of biobased epoxidized fatty acid esters on mechanical and thermal properties of poly(lactic acid)

et al. 2016

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Poly(lactic acid)-PLA is a polyester that can be produced from lactic acid derived from renewable resources. This polymer offers attracting uses in packaging industry due to its biodegradability and high tensile strength. However, PLA is quite brittle, which limits its applications. To overcome this drawback, PLA was plasticized with epoxy-type plasticizer derived from a fatty acid, octyl epoxy stearate (OES) at different loading (1, 3, 5, 10, 15 and 20 phr). The addition of OES decreases the glass transition temperature and provides a remarkable increase in elongation at break and impact absorbed energy.Plasticizer saturation occurs at relatively low concentrations of about 5 phr OES; higher concentration leads to phase separation as observed by field emission scanning electron microscopy (FESEM). Optimum balanced mechanical properties are obtained at relatively low concentrations of OES (5 phr) thus indicating the usefulness of this material as environmentally friendly plasticizer for PLA industrial formulations.

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Polylactic acid/polyethylene glycol blend fibres prepared via melt electrospinning: effect of polyethylene glycol content

Cited by 18 publications

References 35 publications

Solution blow spinning fibres: New immunologically inert substrates for the analysis of cell adhesion and motility

Solution blow spinning fibres: New immunologically inert substrates for the analysis of cell adhesion and motility

The effects of processing parameters on the morphology of PLA/PEG melt electrospun fibers

Plasticizing effect of biobased epoxidized fatty acid esters on mechanical and thermal properties of poly(lactic acid)

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