Polymegathism, Pleomorphism, and Endothelial Cell Count after Selective Laser Trabeculoplasty

Kurysheva, N I; Shatalova, E.O.

doi:10.4172/0974-8369.1000343

Cited by 5 publications

(3 citation statements)

References 15 publications

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“…9 Many authors, including us at an earlier date, noted the appearance of dark spots resembling endothelium clefts within the first hours and days after SLT. [8][9][10][11] This phenomenon may be explained by the transient reduction in cells possibly due to inflammatory cell attachment on the endothelium or cellular oedema separating the endothelial cells from the Descemet's membrane impairing their ECC. This inflammation is associated with the increase in corneal thickness due to oedema.…”

Section: Discussionmentioning

confidence: 99%

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Factors affecting the corneal endothelium after selective laser trabeculoplasty in primary open angle and angle closure glaucoma

2021

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PurposeTo study the factors affecting the corneal endothelium after selective laser trabeculoplasty (SLT) in primary open angle glaucoma (POAG) and primary angle closure glaucoma (PACG).MethodThis prospective interventional study included 56 patients (56 eyes) with POAG and 55 patients (55 eyes) with PACG. All participants received a standard SLT session. Patients with PACG were pretreated with laser peripheral iridotomy for at least 2 months before SLT. Corneal endothelium cell count (ECC), pleomorphism and polymegathism were measured before SLT, as well as at the increments of 1 hour, 1 day, 1 week, 1 month, 3 months and 6 months following SLT using confocal microscopy. A multiple regression analysis was applied to detect the factors affecting the ECC in the long-term post-SLT period.ResultsIn both groups, the mean ECC significantly decreased from the baseline after SLT. While in POAG, corneal endothelium recovered within 1 month, in PACG, its damage persisted throughout the whole follow-up period.According to the multiple analysis, baseline ECC (β=0.891, p=0.000 in POAG and β=0.706, p=0.000 in PACG) and age (β=−0.227, p=0.000 in POAG and β=−0.196, p=0.000 in PACG) were the common risk factors affecting ECC in both glaucoma forms, while the initial anterior chamber depth (β=0.254, p=0.000), only in PACG. The duration of glaucoma treatment (β=−0.317, p=0.043 in POAG and β=−0.302, p=0.047 in PACG) and pigmented deposits on the corneal endothelium in PACG (β=−0.326, p=0.019) were the risk factors determined in the univariate analysis.ConclusionAge and the baseline ECC are the risk factors for corneal endothelium damage after SLT in POAG and PACG. Shallow anterior chamber may affect corneal endothelium in PACG. These data should be considered when choosing an algorithm for glaucoma treatment.

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Section: Discussionmentioning

confidence: 99%

“…Our observations have shown that the maximum changes occur within an hour after SLT and are completely restored by the end of the first month after surgery. 8 According to other authors, these changes persist for more than a month. 9 In general, only a few studies on the ECC before and after SLT have been published.…”

Section: Significance Of the Studymentioning

confidence: 96%

Factors affecting the corneal endothelium after selective laser trabeculoplasty in primary open angle and angle closure glaucoma

2021

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“…e most frequent adverse reactions of SLT in both glaucoma forms are mild irritation during the first days after the procedure, reactive IOP rise, corneal syndrome, bleeding, and transient changes in corneal endothelium [21,22]. e literature describes the cases of such severe complications in the SLT postoperative period as haze and corneal edema [23].…”

Section: Discussionmentioning

confidence: 99%

Selective Laser Trabeculoplasty Protects Glaucoma Progression in the Initial Primary Open-Angle Glaucoma and Angle-Closure Glaucoma after Laser Peripheral Iridotomy in the Long Term

Kurysheva¹,

Lepeshkina

2019

BioMed Research International

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Purpose. To compare the ability of SLT in preventing glaucoma progression in the initial primary angle-closure glaucoma (PACG) after laser peripheral iridotomy and primary open-angle glaucoma (POAG) in the long term. Methods. 60 patients with the initial stage of PACG after laser peripheral iridotomy and 64 initial POAG patients were recruited in a prospective study. Complete success of selective laser trabeculoplasty (SLT) was defined as a 20% intraocular pressure (IOP) reduction with topical hypotensive medications without any hypotensive intervention. Pre-SLT rate of progression and post-SLT rate of progression (ROP) was detected in the both groups by means of the trend and the event analysis of perimetry, the Guided Progression Analysis, and the optical coherence tomography- (OCT-) based negative trend for either the thickness of the peripapillary retinal nerve fiber layer (RNFL) or ganglion cell complex (GCC). Results. IOP decreased significantly after SLT in both the groups. 30% in PACG and 19% in POAG had the progression according to perimetry and 49% in PACG and 40% in POAG had the progression, respectively, according to OCT. After SLT, ROP was reduced from −0.14 ± 0.39 dB/year to −0.08 ± 0.48 dB/year, p=0.034, in PACG and from −0.09 ± 0.36 dB/year to −0.04 ± 0.43 dB/year, p=0.021, in POAG. According to RNFL trend analysis, ROP was reduced from −1.86 ± 2.9 μm/year to −1.38 ± 2.2 μm/year, p=0.039, and from −1.24 ± 2.23 μm/year to −0.76 ± 1.73 μm/year, p=0.037, in PACG and POAG, and according to GCC, ROP was reduced from −1.88 ± 2.9 μm/year to −1.34 ± 2.0 μm/year, p=0.040, and from −1.35 ± 2.16 μm/year to −0.91 ± 1.86 μm/year, p=0.040, in PACG and POAG, respectively. ROP was significantly faster in PACD than in POAG between 2 and 6 years after SLT: −0.15 ± 0.46 dB/year and 0.02 ± 0.38 dB/year (p=0.042). However, it did not differ significantly according to OCT. Conclusion. SLT is an effective treatment for initial PACG after LPI and POAG that can prevent functional and structural deterioration in the long term.

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Comeal Endothelium cell segmentation and count using K-means and watershed algorithms

Kumar¹,

Srinivasa

2018

2018 Second International Conference on Advances in Electronics, Computers and Communications (ICAECC)

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Polymegathism, Pleomorphism, and Endothelial Cell Count after Selective Laser Trabeculoplasty

Cited by 5 publications

References 15 publications

Factors affecting the corneal endothelium after selective laser trabeculoplasty in primary open angle and angle closure glaucoma

Factors affecting the corneal endothelium after selective laser trabeculoplasty in primary open angle and angle closure glaucoma

Selective Laser Trabeculoplasty Protects Glaucoma Progression in the Initial Primary Open-Angle Glaucoma and Angle-Closure Glaucoma after Laser Peripheral Iridotomy in the Long Term

Comeal Endothelium cell segmentation and count using K-means and watershed algorithms

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