Polymer-based 3D microcones for application in SERS

Lettrichova, Ivana; Pudiš, Dušan; Gaso, Peter; Jandura, Daniel; Kováč, J.; Laurenčíková, A.; Novák, J.; Goraus, Matej

doi:10.1117/12.2518517

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…Particularly, two-photon polymerization (2PP) technology, a microscale 3D printing technology, has demonstrated its value in fabrication of various microoptics and microtools at tips of optical fibers [311][312][313][314][315]. 2PP technology has also shown its capability of generating submicron-scale structures that can facilitate plasmonic surface-enhanced spectroscopies, such as SERS [316][317][318] and potentially metal-enhanced fluorescence (MEF). Furthermore, an optical fiber-based SERS probe was successfully developed by using 2PP technology for in vitro bacteria detection, which confirms that 2PP technology holds great potential for fabrication of novel diagnostic spectroscopy probes [319].…”

Section: Technical Unmet Needs and Opportunitiesmentioning

confidence: 99%

Optical spectroscopy for in vivo medical diagnosis—a review of the state of the art and future perspectives

2020

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When light is incident to a biological tissue surface, combinations of optical processes occur, such as reflection, absorption, elastic and non-elastic scattering, and fluorescence. Analysis of these light interactions with the tissue provides insight into the metabolic and pathological state of the tissue. Furthermore, in vivo diagnosis of diseases using optical spectroscopy enables in situ rapid clinical decisions without invasive biopsies. For in vivo scenarios, incident light can be delivered in a highly localized manner to tissue via optical fibers, which are placed within the working channels of minimally invasive clinical tools, such as endoscopes. There has been extensive development in the accuracy and specificity of these optical spectroscopy techniques since the earliest in vivo examples were published in the academic literature in the early ‘90s, and there are now commercially available systems that have undergone medical and clinical trials. In this review, several types of optical spectroscopy techniques (elastic optical scattering spectroscopy, fluorescence spectroscopy, Raman spectroscopy, and multimodal spectroscopy) for the diagnosis and monitoring of diseases states of tissue in an in vivo setting are introduced and explored. Examples of the latest and most impactful works for each technique are then critically reviewed. Finally, current challenges and unmet clinical needs are discussed, followed by future opportunities, such as point-based spectroscopies for robot-guided surgical interventions.

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Section: Technical Unmet Needs and Opportunitiesmentioning

confidence: 99%

Optical spectroscopy for in vivo medical diagnosis—a review of the state of the art and future perspectives

2020

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“…Lately, we presented polymer-based 3D structures prepared via dip in laser lithography using Nanoscribe Photonic Professional 3D lithography system. As 3D structures, Ag-coated IP-Dip microcones with different protrusions were performed and used as SERS substrate 10 . According to the study of Oo et al it was shown that the e-field at the tip of the pyramid is not as strong as at the base of the pyramid 9 .…”

Section: Introductionmentioning

confidence: 99%

IP-Dip inverted pyramids for application in SERS

Lettrichova

Pudiš²,

Jandura³

et al. 2022

22nd Polish-Slovak-Czech Optical Conference on Wave and Quantum Aspects of Contemporary Optics

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In this paper, we present inverted pyramids patterned in the surface of IP-Dip polymer that can be used as a SERS substrate. Inverted pyramids are prepared using direct laser writing lithography and they are metal-coated in the next step. Prepared SERS structure consists of field of 40x40 pyramids with base of 3 μm and two depths – 2 and 3 μm. Afterwards, an Au layer with 4 different thicknesses (10 nm, 20 nm, 30 nm and 40 nm) is evaporated. Transmission spectra were simulated and measured for characterization of prepared structures. The micro-Raman measurements using Rhodamine 6G in aqueous solution at concentration of 10-2 M as the probe molecule were performed.

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Polymer-based 3D microcones for application in SERS

Cited by 2 publications

References 11 publications

Optical spectroscopy for in vivo medical diagnosis—a review of the state of the art and future perspectives

Optical spectroscopy for in vivo medical diagnosis—a review of the state of the art and future perspectives

IP-Dip inverted pyramids for application in SERS

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