Polymer-Based Biomaterials: An Emerging Electrochemical Sensor

Pandey, Annu; Jain, Rajeev

doi:10.1007/978-3-030-40513-7_60

Cited by 3 publications

(2 citation statements)

References 61 publications

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“…Owing to its innocuous, exceptional film-forming ability, outstanding adherence, and impulsive toughness, its use as a bioactive material in sensor applications has increased. The amino groups present in CS serve as ligands and combine with TiO 2 NPs to produce a CS-Ti complex that has greater stability [ 54 , 55 ]. The addition of CS to TiO 2 NPs improves its conductivity as well as the sensitivity, stability, and biomolecular-sensing capabilities of the immunosensor due to the high electrocatalytic performance of CS [ 56 ].…”

Section: Introductionmentioning

confidence: 99%

Functionalized Titanium Dioxide Nanoparticle-Based Electrochemical Immunosensor for Detection of SARS-CoV-2 Antibody

et al. 2022

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The advancement in biosensors can overcome the challenges faced by conventional diagnostic techniques for the detection of the highly infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hence, the development of an accurate, rapid, sensitive, and selective diagnostic technique can mitigate adverse health conditions caused by SARS-CoV-2. This work proposes the development of an electrochemical immunosensor based on bio-nanocomposites for the sensitive detection of SARS-CoV-2 antibodies through the differential pulse voltammetry (DPV) electroanalytical method. The facile synthesis of chitosan-functionalized titanium dioxide nanoparticles (TiO2-CS bio-nanocomposites) is performed using the sol-gel method. Characterization of the TiO2-CS bio-nanocomposite is accomplished using UV-vis spectroscopy, Raman spectroscopy, X-ray diffraction (XRD), and transmission electron microscopy (TEM). The electrochemical performance is studied using cyclic voltammetry (CV), DPV, and electrochemical impedance spectroscopy (EIS) for its electroanalytical and biosensing capabilities. The developed immunosensing platform has a high sensitivity with a wide range of detection from 50 ag mL−1 to 1 ng mL−1. The detection limit of the SARS-CoV-2 antibody in buffer media is obtained to be 3.42 ag mL−1 and the limit of quantitation (LOQ) to be 10.38 ag mL−1. The electrochemical immunosensor has high selectivity in different interfering analytes and is stable for 10 days. The results suggest that the developed electrochemical immunosensor can be applicable for real sample analysis and further high-throughput testing.

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Section: Introductionmentioning

confidence: 99%

Functionalized Titanium Dioxide Nanoparticle-Based Electrochemical Immunosensor for Detection of SARS-CoV-2 Antibody

et al. 2022

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“…18,19 Based upon the findings, the use of biomaterials is becoming more popular to reduce the consumption of nonrenewable resources. 20,21 Biopolymers are commonly referred to as biomolecules made up of multiple monomeric units covalently linked together. The term ''bio'' denotes that the materials used are derived from plants or living organisms and are biodegradable.…”

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confidence: 99%

Biopolymer-based electrospun fibers in electrochemical devices: versatile platform for energy, environment, and health monitoring

et al. 2022

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Multifunctional Modified Chitosan Biopolymers for Dual Applications in Biomedical and Industrial Field: Synthesis and Evaluation of Thermal, Chemical, Morphological, Structural, In Vitro Drug-Release Rate, Swelling and Metal Uptake Studies

Chopra

Chohan

Sharma

et al. 2022

Sensors

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The hydrogel materials are getting attention from the research due to their multidimensional usage in various fields. Chitosan is one of the most important hydrogels used in this regard. In this paper multifunctional binary graft copolymeric matrices of chitosan with monomer AA and various comonomers AAm and AN were prepared by performing free radical graft copolymerization in the presence of an initiator KPS. The binary grafting can be done at five different molar concentrations of binary comonomers at already optimized concentration of AA, KPS and other reaction conditions such as time, temperature, solvent amount, etc. Various optimum reaction conditions were investigated and presented in this work; the backbone as well as binary grafts Ch-graft-poly (AA-cop-AAm) and Ch-graft-poly (AA-cop-AN) were characterized via various physio-chemical techniques of analysis such as SEM analysis, Xray diffraction (XRD), TGA/DTA and FTIR. In the batch experiments, the binary grafts were investigated for the percent swelling with respect to pH (pH of 2.2, 7.0, 7.4 and 9.4) and time (contact time 1 to 24 h). Uploading and controllable in vitro release of the drug DS (anti-inflammatory) was examined with reverence to gastrointestinal pH and time. The binary grafts showed significantly better-controlled drug diffusion than the unmodified backbone. The kinetic study revealed that the diffusion of the drug occurred by the non-Fickian way. In the case of separation technologies, experiments (batch tests) were executed for the toxic bivalent metal ions Fe (II) and Pb (II) sorption from the aqueous media with respect to the parameters such as interaction period, concentration of fed metal ions in solution, pH and temperature. The binary grafted matrices showed superior results compared to chitosan. The kinetics study revealed that the matrices show pseudo-second order adsorption. The graft copolymer Ch-graft-poly (AA-cop-AAm) provided superior results in sustainable drug release as well as metal ion uptake. The study explored the potential of chitosan-based materials in the industry as well in the biomedical field. The results proved these to be excellent materials with a lot of potential as adsorbents.

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Polymer-Based Biomaterials: An Emerging Electrochemical Sensor

Cited by 3 publications

References 61 publications

Functionalized Titanium Dioxide Nanoparticle-Based Electrochemical Immunosensor for Detection of SARS-CoV-2 Antibody

Functionalized Titanium Dioxide Nanoparticle-Based Electrochemical Immunosensor for Detection of SARS-CoV-2 Antibody

Biopolymer-based electrospun fibers in electrochemical devices: versatile platform for energy, environment, and health monitoring

Multifunctional Modified Chitosan Biopolymers for Dual Applications in Biomedical and Industrial Field: Synthesis and Evaluation of Thermal, Chemical, Morphological, Structural, In Vitro Drug-Release Rate, Swelling and Metal Uptake Studies

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