Polymer based biosensor for rapid electrochemical detection of virus infection of human cells

Kiilerich-Pedersen, Katrine; Poulsen, Claus; Jain, Titoo; Rozlosnik, Noémi

doi:10.1016/j.bios.2011.07.053

Cited by 30 publications

(17 citation statements)

References 33 publications

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“…Cleric-Pederson, Roziosnik et al [99] developed tosylate doped PEDOT biosensor electrodes for fast detection of virus in human cell cultures. The use of such sensors may reduce significantly time required for virus diagnosis.…”

Section: Nucleic Acid Electrochemical (Ec) Sensorsmentioning

confidence: 99%

Biomedical applications of electrically conductive polymeric systems

Jagur‐Grodzinski

2012

E-Polymers

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Properties of the electrically conductive polymers (ECPs) enable introduction of several novel applications in various fields, among others, as biomedical materials. Their use as scaffolds for tissue engineering and recovery of damaged neural tissues is especially advantageous. They may also be used for the electrically induced drug release and delivery, and as very sensitive biosensors for clinical applications. Another use is the detection and precision of the biologically important chemical materials. They have been shown to modulate and accelerate activities of the nerve, skeletal, muscle, and bone cells. Cell growth, migration and adhesion, may be stimulated by applying electric potential. Synthesis of DNA, secretion of proteins, and transformations of stem cells may be enhanced. Clinical analysis using ECP-based biosensors make possible the precise determination of the exact composition of individual DNA molecules, and thus enable early detection and treatment of genetically related diseases. Electrochemical (EC) approach of ECP-sensors enables precise determination of concentrations of several biologically important chemicals.

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Section: Nucleic Acid Electrochemical (Ec) Sensorsmentioning

confidence: 99%

Biomedical applications of electrically conductive polymeric systems

Jagur‐Grodzinski

2012

E-Polymers

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“…6.9b displays an eight gold electrode array used for nanotoxicity assays using electrical impedance sensing. Indeed, the effect of these compounds leads to a change of morphology of the cells that in turn is transduced to a change of resistance as described by Kiilerich and co-workers in 2011 (Kiilerich-Pedersen et al 2011). They used an all-polymer electrochemical biosensor constituted by conductive polymer PEDOT:TsO microelectrodes and electrochemical impedance spectroscopy as detection technique leading to a label-free method.…”

Section: Cell-based Loc-biosensorsmentioning

confidence: 99%

Lab-on-a-Chip Devices and Micro-Total Analysis Systems

Castillo-León¹,

Svendsen²

2015

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“…Besides low material costs CPs can be modified in a number of ways and thus offer a wide range of possibilities for controlling their mechanical, electrical and surface properties [3][4][5][6][7][8][9]. Besides low material costs CPs can be modified in a number of ways and thus offer a wide range of possibilities for controlling their mechanical, electrical and surface properties [3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…Conducting polymers have also been proved to be useful for a broad range of applications in biomedical engineering [10] One example for these polymers is the poly (3, 4ethylenedioxythiophene) (PEDOT). Moreover, this material proved to be suitable for the fabrication of label-free electrochemical biosensors and in particular for EIS systems [3,[13][14][15][16]. for antistatic coatings [11,12].…”

Section: Introductionmentioning

confidence: 99%

Performance Improvement by Layout Designs of Conductive Polymer Microelectrode Based Impedimetric Biosensors

et al. 2014

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In this work we present a theoretical, computational, and experimental evaluation of the performance of an impedimetric biosensor based on interdigitated conductive polymer (PEDOT:TsO) microelectrodes in a microfluidic system. The influence of the geometry of the electrodes and microchannels on the electrochemical performance of the biosensor was exploited to improve the detection system. The developed model allowed us to predict the performance of the electrochemical system, and thus to optimize the geometry for electrochemical impedance spectroscopy (EIS). Finally, the optimized electrode design was validated by the detection of a clinically relevant target (ampicillin) at picomolar concentrations.

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Polymer based biosensor for rapid electrochemical detection of virus infection of human cells

Cited by 30 publications

References 33 publications

Biomedical applications of electrically conductive polymeric systems

Biomedical applications of electrically conductive polymeric systems

Lab-on-a-Chip Devices and Micro-Total Analysis Systems

Performance Improvement by Layout Designs of Conductive Polymer Microelectrode Based Impedimetric Biosensors

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