Polymer-Based Functional Cantilevers Integrated with Interdigitated Electrode Arrays—A Novel Platform for Cardiac Sensing

Kanade, Pooja P.; Oyunbaatar, Nomin-Erdene; Lee, Dong-Weon

doi:10.3390/mi11040450

Cited by 13 publications

(6 citation statements)

References 30 publications

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“…The final note of interest is the number of papers in recent years that overlap between two different sensors. This includes the use of: dielectrophoresis and ECIS [ 170 ], microcantilevers and ECIS [ 180 ], QCM and ECIS [ 125 ], microcantilevers and photoacoustics [ 58 ]. The benefit of these systems being that it is easier to correctly distinguish two separate species with two sets of tests to compare.…”

Section: Discussionmentioning

confidence: 99%

“…Platforms to easily measure this response would significantly increase efficiency. Kanade et al have demonstrated a platform for simultaneous mechanical and electrical monitoring of cardiomyocytes, using a microcantilever combined with ECIS [ 180 ]. Multiple sensor platforms such as lab-on-a-chip (LOC) technologies are becoming increasingly prevalent with the advancement and integration of microfluidics and relatively low-cost and facile production methods such as aerosol-jet printing [ 181 ] and inkjet printing [ 182 , 183 ].…”

Section: Electrical Biosensorsmentioning

confidence: 99%

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Biosensors Based on Mechanical and Electrical Detection Techniques

Chalklen

Jing

Kar‐Narayan

2020

Sensors

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Biosensors are powerful analytical tools for biology and biomedicine, with applications ranging from drug discovery to medical diagnostics, food safety, and agricultural and environmental monitoring. Typically, biological recognition receptors, such as enzymes, antibodies, and nucleic acids, are immobilized on a surface, and used to interact with one or more specific analytes to produce a physical or chemical change, which can be captured and converted to an optical or electrical signal by a transducer. However, many existing biosensing methods rely on chemical, electrochemical and optical methods of identification and detection of specific targets, and are often: complex, expensive, time consuming, suffer from a lack of portability, or may require centralised testing by qualified personnel. Given the general dependence of most optical and electrochemical techniques on labelling molecules, this review will instead focus on mechanical and electrical detection techniques that can provide information on a broad range of species without the requirement of labelling. These techniques are often able to provide data in real time, with good temporal sensitivity. This review will cover the advances in the development of mechanical and electrical biosensors, highlighting the challenges and opportunities therein.

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Section: Discussionmentioning

confidence: 99%

Section: Electrical Biosensorsmentioning

confidence: 99%

Biosensors Based on Mechanical and Electrical Detection Techniques

Chalklen

Jing

Kar‐Narayan

2020

Sensors

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“…Over the years, numerous devices and techniques have been developed to measure the cardiotoxicity caused by potential drugs. − Several studies have presented interesting techniques to measure the drug-induced cardiac contractility. − Atomic force microscopy (AFM) is a technique that employs a microcantilever tip to scan the surface of a cardiomyocyte and measure the contraction force. Cantilever-based techniques have been used for studying human pluripotent stem-derived cardiomyocyte-based tissue, embryoid bodies, and for neonatal rats’ ventricular myocytes (NRVMs) upon mechanical stimulation. − Ossola et al combined AFM with a patch clamp technique, whereas Gaitas et al developed a polyimide (PI)-based microcantilever for sensing cardiac contractility of a single cell. , Pribyl et al utilized a silicon nitride cantilever to develop an AFM-based cardiac biosensing platform .…”

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confidence: 99%

Real-Time Monitoring of Changes in Cardiac Contractility Using Silicon Cantilever Arrays Integrated with Strain Sensors

et al. 2021

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This paper proposes the use of sensor-integrated silicon cantilever arrays to measure drug-induced cardiac toxicity in real time. The proposed cantilever sensors, unlike the conventional electrophysiological methods, aim to evaluate cardiac toxicity by measuring the contraction force of the cardiomyocytes corresponding to the target drugs. The surface of the silicon cantilever consists of microgrooves to maximize the alignment and the contraction force of the cardiomyocytes. This type of surface pattern also helps in the maturation of the cardiomyocytes by increasing the sarcomere length. The preliminary characterization of the cantilever sensors was performed on the cantilever surface, with the cardiomyocytes seeded with a density of 1000 cells/mm 2 , and the cardiac contractility was measured as a function of the culture days. The change in the contraction force of the cardiomyocytes due to the drug concentration was successfully measured through the integrated strain sensor in the culture media. The reliability of the sensor-integrated cantilevers and the feasibility of their mass production ensure that they meet the practical requirements in the medical applications.

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“…In this Special Issue, 10 technical papers are published on piezoelectric devices [ 1 , 2 , 3 , 4 ], biomedical devices [ 5 , 6 ], micromachining [ 7 , 8 ], and complementary metal-oxide-semiconductor (CMOS) logic devices [ 9 , 10 ]. For the piezoelectric devices, high-density piezoelectric micromachined ultrasonic transducer array based on patterned aluminum nitride thin film is introduced for imaging application [ 1 ].…”

mentioning

confidence: 99%

“…Two papers investigate polymer-based functional cantilevers integrated with interdigitated electrode arrays and magnetic microfluidic pump for novel cardiac sensing and in vivo bone remodeling application, respectively [ 5 , 6 ]. Reference [ 5 ] demonstrates a biomedical device that can simultaneously measure electrophysiology and contraction force of cardiomyocytes using a photosensitive polymer-based cantilever, with a pair of metal-based interdigitated electrodes on its surface. A magnetically operated implantable microfluidic pump is introduced for in vivo studies of bone intramedullary fluid modulation for the potential application in bone density augmentation study in rat femora [ 6 ].…”

mentioning

confidence: 99%