Polymer-Based Functional Materials Loaded with Metal-Based Nanoparticles as Potential Scaffolds for the Management of Infected Wounds

Abstract

Wound infection due to bacterial invasion at the wound site is one of the primary challenges associated with delayed wound healing. Microorganisms tend to form biofilms that protect them from harm, leading to their multidrug resistance. The alarming increase in antibiotic resistance poses a threat to wound healing. Hence, the urgent need for novel wound dressing materials capable of managing bacterial infection is crucial for expediting wound recovery. There is considerable interest in polymeric wound dressings embedded with bioactive substances, such as metal-based nanoparticles, as potential solutions for treating microbially infected wounds. Metal-based nanoparticles have been widely used for the management of infected wounds due to their broad antimicrobial efficacy. This review focuses on polymer-based and bioactive wound dressings loaded with metal-based nanoparticles like silver, gold, magnesium oxide, or zinc oxide. When compared, zinc oxide-loaded dressings exhibited higher antibacterial activity against Gram-positive strains and silver nanoparticle-loaded dressings against gram-negative strains. However, wound dressings infused with both nanoparticles displayed a synergistic effect against both strains of bacteria. Furthermore, these dressings displayed antibiofilm activity and the generation of reactive oxygen species while accelerating wound closure both in vitro and in vivo.

A Review of Recent Advancements and Perspectives of Nanotechnology in the Application of Biomedical Imaging and Instrumentation

“…Cells and tumourbearing mice Nqoro, et al [58] Polymer-Based Nanoparticles Biocompatible and nontoxic bio-endogenous compounds include DNA in this category.…”

pH-Responsive Co-Assembled Peptide Hydrogel to Inhibit Drug-Resistant Bacterial Infection and Promote Wound Healing

“…Bacterial contamination of wounds can lead to increased secretion of pro-inflammatory cytokines, which can prolong the inflammatory phase and create chronic wounds even when the bacteria are not cleared . Therefore, it is extremely important to eliminate or suppress bacteria in wound infection . However, during bacterial infection, the bacteria produce acidic metabolites that cause the wound environment pH to drop to 4.5–6.5. , Although traditional dressings such as gauze, polymer bandages, and cotton wool are widely used in skin wound management, they cannot protect against bacterial infections and their frequent replacement can damage the new skin tissues. , In recent years, various antibacterial wound dressing materials have been developed, including hydrogel-based drug carriers that provide a moist environment to prevent scarring during healing and antibacterial activity that can hasten wound healing. − Antibacterial agents can be incorporated into the gel matrix, improving their bioavailability …”

“…5 Therefore, it is extremely important to eliminate or suppress bacteria in wound infection. 6 However, during bacterial infection, the bacteria produce acidic metabolites that cause the wound environment pH to drop to 4.5−6.5. 7,8 Although traditional dressings such as gauze, polymer bandages, and cotton wool are widely used in skin wound management, they cannot protect against bacterial infections and their frequent replacement can damage the new skin tissues.…”