Polymer-Based Nanofiber–Nanoparticle Hybrids and Their Medical Applications

Abstract

The search for higher-quality nanomaterials for medicinal applications continues. There are similarities between electrospun fibers and natural tissues. This property has enabled electrospun fibers to make significant progress in medical applications. However, electrospun fibers are limited to tissue scaffolding applications. When nanoparticles and nanofibers are combined, the composite material can perform more functions, such as photothermal, magnetic response, biosensing, antibacterial, drug delivery and biosensing. To prepare nanofiber and nanoparticle hybrids (NNHs), there are two primary ways. The electrospinning technology was used to produce NNHs in a single step. An alternate way is to use a self-assembly technique to create nanoparticles in fibers. This paper describes the creation of NNHs from routinely used biocompatible polymer composites. Single-step procedures and self-assembly methodologies are used to discuss the preparation of NNHs. It combines recent research discoveries to focus on the application of NNHs in drug release, antibacterial, and tissue engineering in the last two years.

Structural Characterization Analyses of Low Brass Filler Biomaterial for Hard Tissue Implanted Scaffold Applications

“…These implanted scaffolds are translational therapeutic approaches [5] using tissue engineering techniques [6] to treat degenerative diseases [7] and improve cartilage regeneration efficiency [8] for osteoarthritis patients. At present, titanium filler [9] is still the most commonly used in metallic scaffolds [10] in advanced combinations with polymer-based biomaterials [11][12][13] during the green composite fabrication processes [14]. However, the existing titanium dioxide filler in these applications [15] was over-strengthened or too hard, resulting in a thin oxide surface layer not being discussed [16].…”

Electrospun Nanofiber Membranes for Air Filtration: A Review

“…However, since the same charge is applied to the two fluids, and due to the principle of like–like repulsion, the two materials are often separated due to repulsion, which poses great operational difficulties. After the researchers’ exploration and innovation, Yu et al [ 97 , 98 ] proposed methods to improve the spinneret, such as arranging internal capillaries in a circular spinning head to realize side-by-side electrospinning or using an eccentric spinning head that has an elliptical outer nozzle, including an inner circle side and a crescent side. As shown in the eccentric circle in Figure 4 b,d, the spinning head is nested, but the center of the circle is not on the same axis.…”

Electrospun Coaxial Fibers to Optimize the Release of Poorly Water-Soluble Drug

“…The high specific surface area of fibers is beneficial for drug dissolution. The required drug dissolution process can be customized in accordance with the composition and structure of the fibers, thereby manipulating the controlled dissolution of the drug [ 7 , 29 , 30 , 31 ].…”