2002
DOI: 10.1016/s0378-5173(02)00183-7
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Polymer based pH-sensitive carriers as a means to improve the cytoplasmic delivery of drugs

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Cited by 89 publications
(49 citation statements)
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“…27,28 As a continuation of our investigation of pH-sensitive liposomes containing the PEAA polymer, in the present study we have evaluated parameters influencing release of vesicular contents. We demonstrated that pH-sensitive vesicles comprised of different phosphatidylcholines, cholesterol, and negatively charged and protonable amino lipids can be constructed by insertion of lipid-anchored PEAA without loss of vesicular contents.…”
Section: Discussionmentioning
confidence: 99%
“…27,28 As a continuation of our investigation of pH-sensitive liposomes containing the PEAA polymer, in the present study we have evaluated parameters influencing release of vesicular contents. We demonstrated that pH-sensitive vesicles comprised of different phosphatidylcholines, cholesterol, and negatively charged and protonable amino lipids can be constructed by insertion of lipid-anchored PEAA without loss of vesicular contents.…”
Section: Discussionmentioning
confidence: 99%
“…132 , 135 , 136 Polymeric components with pH-sensitive (pH-cleavable) bonds are used to produce stimuli-responsive drug delivery systems that are stable in the circulation or in normal tissues but acquire the ability to degrade and release the entrapped drugs in body areas or cell compartments with lowered pH, such as tumors, or cell cytoplasm or endosomes. [137][138][139] A variety of liposomes 140 , 141 and polymeric micelles 123 , 142 , 143 have been described that include the components with acid-labile bonds. Serum-stable, long-circulating PEGylated pH-sensitive liposomes were also prepared using the combination of PEG and the pH-sensitive terminally alkylated copolymer of N-isopropylacrylamide and methacrylic 139 on the same liposome, since the attachment of the pH-sensitive polymer to the surface of liposomes might facilitate liposome destabilization and drug release in compartments with decreased pH values.…”
Section: Targeting Via Stimuli Sensitivitymentioning
confidence: 99%
“…Complexation of hydrophobically-modified copolymers of NIPAN (either randomly or terminally alkylated) with EPC/Chol liposomes resulted in an enhancement of in vitro release of both highly-water soluble markers and amphipathic drugs upon acidification [14,77,78]. Liposomes anchoring randomlyalkylated NIPAM and containing ara-C were shown to mediate a higher cytotoxicity towards J774 macrophage-like cells as compared to non-pH-sensitive liposomes [78]. More recently, different NIPAM based copolymers were synthesized and evaluated in terms of their ability to confer pH-sensitivity and serum stability [78 -80] as well as steric stabilization to liposomes [79,80].…”
Section: Association Of Ph-sensitive Polymers With Liposomesmentioning
confidence: 99%