2011
DOI: 10.1021/bm200991b
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Polymer Brush Controlled Bioinspired Calcium Phosphate Mineralization and Bone Cell Growth

Abstract: Polymer brushes on thiol-modified gold surfaces were synthesized by using terminal thiol groups for the surface-initiated free radical polymerization of methacrylic acid and dimethylaminoethyl methacrylate, respectively. Atomic force microscopy shows that the resulting poly(methacrylic acid) (PMAA) and poly(dimethylaminoethyl methacrylate) (PDMAEMA) brushes are homogeneous. Contact angle measurements show that the brushes are pH-responsive and can reversibly be protonated and deprotonated. Mineralization of th… Show more

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Cited by 25 publications
(27 citation statements)
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“…On the other hand, some authors reported that cells have greater adhesion and proliferation on hydrophobic surfaces or on surfaces with intermediate contact angles. Materials able to integrate with bone, for example, titanium and hydroxyapatite, are hydrophilic 141, 142. On the other hand, many polymers used for tissue engineering are hydrophobic in their native state, and require surface modification or wetting procedures before cell seeding.…”
Section: Active Cell‐surface Interfacesmentioning
confidence: 99%
“…On the other hand, some authors reported that cells have greater adhesion and proliferation on hydrophobic surfaces or on surfaces with intermediate contact angles. Materials able to integrate with bone, for example, titanium and hydroxyapatite, are hydrophilic 141, 142. On the other hand, many polymers used for tissue engineering are hydrophobic in their native state, and require surface modification or wetting procedures before cell seeding.…”
Section: Active Cell‐surface Interfacesmentioning
confidence: 99%
“…9 In contrast, there are only few studies on the effects of interfaces on calcium phosphate nucleation and growth, although the recent past has seen an increasing number of articles on the topic. [11][12][13][14][15][16][17][18][19] Likewise, the effects of (poly)cations on calcium phosphate and calcium carbonate mineralization have only recently begun to be addressed. 13,14,[19][20][21][22][23][24][25][26] According to these studies, there are indeed significant differences between (i) bulk and surface mineralization and between (ii) polyanion and polycationcontrolled calcium phosphate mineralization.…”
Section: Introductionmentioning
confidence: 99%
“…The composite materials resulting from the combination of CaP and polymers enable the combination of the advantages of inorganic and organic components that show good biocompatibility and favourable bonding ability with the surrounding host tissue (Mickiewicz et al , ; Johns et al , ). Thus, the resulting composite materials possess structural properties that are superior to either polymers or ceramics alone (Löbbicke et al , ).…”
Section: Introductionmentioning
confidence: 99%
“…In particular, bioinspired CaP hybrid materials have attracted tremendous interest due to their potential applications, dominantly in the biomedical field (Löbbicke et al , ). Such biomimetic mineral formation avoids harsh conditions and enables the synthesis of CaP composites containing different CaP phases.…”
Section: Introductionmentioning
confidence: 99%