Polymer characterization using packed capillary size exclusion and critical adsorption chromatography combined with maldi‐tof mass spectrometry

Huang, Yun; Olesik, Susan V.; Marti, Edward H.

doi:10.1002/(sici)1520-667x(1999)11:1<53::aid-mcs7>3.3.co;2-s

Cited by 8 publications

(19 citation statements)

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“…The key to this approach is to efficiently spray the column eluant onto a target containing the MALDI matrix. This can be done with a commercially available liquid chromatography transform (LCT) from Lab Connections, Inc. (a Mocon company, Northbourough, MA), − home-built units, or with a robotic interface . Figure shows data obtained using the Lab Connections equipment on a broad polydispersity sample of PMMA.…”

Section: Gpc-maldimentioning

confidence: 99%

Mass Spectrometry of Polymers and Polymer Surfaces

2001

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Section: Gpc-maldimentioning

confidence: 99%

Mass Spectrometry of Polymers and Polymer Surfaces

2001

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“…Fei and Murray [41] have reported on-line GPC coupling to a MALDI source. However, to date most GPC-MALDI analysis employs deposition of the GPC effluent onto a MALDI sample target followed by mass analysis [42][43][44][45][46][47][48][49]. This method is not considered to be true on-line hyphenation, when compared to GPC-ESI MS, since the deposition of GPC effluent and subsequent mass analysis occurs in two discrete time events.…”

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confidence: 99%

Comparative studies of poly(dimethyl siloxanes) using automated GPC-MALDI-TOF MS and on-line GPC-ESI-TOF MS

Liu¹,

Maziarz²,

Heiler³

et al. 2003

J. Am. Soc. Mass Spectrom.

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In this study we compare on-line gel permeation chromatography (GPC) electrospray ionization (ESI) time-of-flight (TOF) mass spectrometry (MS) to automated GPC matrix assisted laser desorption ionization (MALDI) TOF MS for poly (dimethylsiloxane) (PDMS) analysis. Average mass values for a hydroxyl-terminated PDMS (OH-PDMS) sample were obtained and compared to traditional GPC that was calibrated with narrow polystyrene standards, by direct ESI and MALDI MS analysis, by a summation of mass spectra of all GPC fractions, and also by the recalibration method determined by both mass spectrometric methods. Quantitatively, the difference noted here between these hyphenated techniques is that GPC-ESI-TOF MS effectively reports the low-mass oligomers and underestimates the high-mass oligomers, while GPC-MALDI-TOF MS effectively reports the high-mass oligomers and underestimates the low-mass oligomers. In the GPC-ESI-TOF MS experiments, ion current suppression was observed in the high molecular weight region. The suppression effect was confirmed by repeatable sample runs and by injecting different PDMS samples. Higher chromatographic resolution was observed for GPC-ESI-TOF MS compared to GPC-MALDI-TOF MS. In fact, truly mono-disperse oligomers were observed in the low molecular weight range from GPC-ESI MS experiments. (J

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“…A review of supercritical fractionation of polymers and copolymers has been published (228). Mass spectrometry has been used in conjunction with SFC and capillary GPC to characterize polypropylene glycol (229).…”

Section: Chromatography the Determination Of Molecular Weight Distributionmentioning

confidence: 99%

Molecular Weight Determination

Cooper

2004

Encyclopedia of Polymer Science and Technology

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Methods to determine molecular weight averages and distributions of polymeric and oligomeric materials have been devised and developed over many decades. Most of the early classical techniques were primary methods which usually yield only a single molecular weight average, based on theory and measurable constants. Of the classical methods only ultracentrifugation can determine a molecular weight distribution. Secondary methods, which depend on the availability of calibration materials, have largely supplanted the older classical techniques. Methods based on fractionation, with molecular weight characterization of the fractions, or chromatography, with continuous determination of molecular weight, are currently used to generate molecular weight distributions. Newer methods based on dynamic light scattering and viscoelastic measurements are available to determine the molecular weight distribution of difficulty soluble materials. Development of methods to describe the molecular weight and compositional distribution of multimer polymers continues to be a vibrant research area.

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Polymer characterization using packed capillary size exclusion and critical adsorption chromatography combined with maldi‐tof mass spectrometry

Cited by 8 publications

References 0 publications

Mass Spectrometry of Polymers and Polymer Surfaces

Mass Spectrometry of Polymers and Polymer Surfaces

Comparative studies of poly(dimethyl siloxanes) using automated GPC-MALDI-TOF MS and on-line GPC-ESI-TOF MS

Molecular Weight Determination

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