Polymer coated polymeric microneedles for intravitreal delivery of dexamethasone

Matadh, Anusha V; Jakka, Deeksha; Pragathi, S G; Poornima, K; Shivakumar, H.N.; Murthy, Reena N; Rangappa, Srinath; Shivanna, Mahesh; Murthy, S. N. B.

doi:10.1016/j.exer.2023.109467

Cited by 14 publications

(2 citation statements)

References 14 publications

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“…Amer and his colleagues also found that MNs with interlocking features provided an 80% increase in adhesion strength and a slight increase in penetration force compared to microneedles without such features [171]. Matadh and colleagues showed that polymer-coated polymeric (PCP) MNs, a novel approach for controlled drug delivery, released drugs gradually and over a more extended period compared to uncoated MNs, which released the entire drug instantaneously in an ex vivo porcine eye mode [172].…”

Section: Clinical Applicationsmentioning

confidence: 99%

Overview of Recent Advances in Nano-Based Ocular Drug Delivery

Liu,

Chen,

2023

IJMS

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Ocular diseases profoundly impact patients’ vision and overall quality of life globally. However, effective ocular drug delivery presents formidable challenges within clinical pharmacology and biomaterial science, primarily due to the intricate anatomical and physiological barriers unique to the eye. In this comprehensive review, we aim to shed light on the anatomical and physiological features of the eye, emphasizing the natural barriers it presents to drug administration. Our goal is to provide a thorough overview of various characteristics inherent to each nano-based drug delivery system. These encompass nanomicelles, nanoparticles, nanosuspensions, nanoemulsions, microemulsions, nanofibers, dendrimers, liposomes, niosomes, nanowafers, contact lenses, hydrogels, microneedles, and innovative gene therapy approaches employing nano-based ocular delivery techniques. We delve into the biology and methodology of these systems, introducing their clinical applications over the past decade. Furthermore, we discuss the advantages and challenges illuminated by recent studies. While nano-based drug delivery systems for ophthalmic formulations are gaining increasing attention, further research is imperative to address potential safety and toxicity concerns.

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Section: Clinical Applicationsmentioning

confidence: 99%

Overview of Recent Advances in Nano-Based Ocular Drug Delivery

Liu,

Chen,

2023

IJMS

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“…An increasing area of interest in TDD is the use of microneedle arrays (MNs), also known as microarray patches, to mechanically breach the SC, epidermis and supercial dermis, therefore bypassing the skin's natural barrier function. [22][23][24][25] A number of different MN technologies exist including hollow, [26][27][28] coated, 29,30 dissolving, 31,32 hydrogel forming, 33,34 and solid MNs. [35][36][37][38] Solid MNs consist of sub-millimetre protrusions usually fabricated from metal or silicon.…”

Section: Introductionmentioning

confidence: 99%

Ex vivo transdermal delivery of ³H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration

Morris,

Long,

Savage

et al. 2023

Nanoscale Adv.

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Leveraging Nanoengineered Microneedle‐Augmented Drug Delivery in Oncological Intervention

Singh,

Shukla

2024

Part & Part Syst Charact

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The landscape of chemotherapy for cancer is experiencing a dramatic transition with the integration of sophisticated drug delivery methods, especially nanoengineered microneedles. Percutaneous vaccination is regarded the optimum therapeutic approach due to the high amount of immune cell accumulation and the rich capillary lymphatic system in the dermis. The curative impact of Microneedles‐based cancer vaccines is suboptimal due to the complicated mix of tumor, host, and environmental variables, as well as the vaccine's restricted loading capacity. As a result, additional enhancements are still needed to accelerate their clinical translation. This article offers a meticulous analysis of the avant‐garde strategies harnessed to augment drug delivery via microneedle. Various tactics, such as tailored nanoparticle carriers, functionalized microneedle arrays, and real‐time monitoring system, work together to improve therapeutic efficacy and prevent off‐target effects. By integrating recent advancement and delineating future trajectories, this article gives an in‐depth analysis of how nanoengineered microneedle‐augmented technologies have the potential to change the face of cancer therapy, heralding in a new era of precision medicine and better outcomes.

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Polymer coated polymeric microneedles for intravitreal delivery of dexamethasone

Cited by 14 publications

References 14 publications

Overview of Recent Advances in Nano-Based Ocular Drug Delivery

Overview of Recent Advances in Nano-Based Ocular Drug Delivery

Ex vivo transdermal delivery of ³H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration

Leveraging Nanoengineered Microneedle‐Augmented Drug Delivery in Oncological Intervention

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Polymer coated polymeric microneedles for intravitreal delivery of dexamethasone

Cited by 14 publications

References 14 publications

Overview of Recent Advances in Nano-Based Ocular Drug Delivery

Overview of Recent Advances in Nano-Based Ocular Drug Delivery

Ex vivo transdermal delivery of 3H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration

Leveraging Nanoengineered Microneedle‐Augmented Drug Delivery in Oncological Intervention

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Product

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Ex vivo transdermal delivery of ³H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration