Polymer Coated Polymeric (PCP) Microneedles for Controlled Delivery of Drugs (Dermal and Intravitreal)

Jakka, Deeksha; Matadh, Anusha V; Shankar, Vijay Kumar; Shivakumar, H.N.; Murthy, S Narasimha

doi:10.1016/j.xphs.2022.05.023

Cited by 16 publications

(3 citation statements)

References 42 publications

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“…Jakka et al investigated the development of polymer-coated polymeric (PCP) microneedles for the controlled release of APIs in dermal and intravitreal drug delivery. PCP microneedles demonstrated sustained release of lidocaine hydrochloride for up to 9 hours in skin tissue and voriconazole intravitreally for 6 hours, suggesting their potential for controlled drug delivery [64].…”

Section: Coated Microneedlesmentioning

confidence: 99%

Revolutionizing Eye Care: Exploring the Potential of Microneedle Drug Delivery

Rojekar,

Parit,

Gholap

et al. 2024

Preprint

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Microneedle technology is a novel platform technology that revolutionizes ocular drug delivery and addresses critical challenges in the treatment of ocular diseases. Routine treatment methods, such as eye drops and intravitreal injections, suffer from low bioavailability and poor patient compliance. So, novel advanced platform technologies are required to overcome these challenges. Microneedle is a minimally invasive and promising alternative technique that helps precisely control drug delivery to targeted tissues and organs. This review investigates the potential impact of microneedle technology for eye care, underscoring recent advancements, underlying mechanisms, and emerging preclinical and clinical uses. Different types of microneedles, including solid, coated, dissolvable, and hollow, have demonstrated their potential and capability to bypass several barriers in the cornea and sclera. This ensures effective drug penetration and delivery. The current innovations in material science and fabrication methods have enhanced the safety and efficacy of microneedles, reducing discomfort and the chances of infections. These microneedle technologies offer sustained and controlled drug delivery, which could improve therapeutic outcomes for various disease conditions like age-related macular degeneration, glaucoma, diabetic neuropathy, etc. In the current review, recent preclinical and clinical studies emphasize microneedle-based ocular drug delivery's feasibility and potential benefits. These include improved pharmacokinetics, reduced dosing frequency, enhanced patient adherence, and, most importantly, microneedles offer versatile platforms for delivering a wide range of small and large molecules and gene therapies. Despite the exciting progress, obstacles such as regulatory barriers, scalability, and long-term biocompatibility persist. It will be essential to tackle these challenges through interdisciplinary research and partnerships to integrate microneedle technology into standard clinical use effectively. Ultimately, microneedle drug delivery offers a revolutionary method that has the potential to significantly enhance the treatment and results of ocular diseases, marking the dawn of a new era in eye care.

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Section: Coated Microneedlesmentioning

confidence: 99%

Revolutionizing Eye Care: Exploring the Potential of Microneedle Drug Delivery

Rojekar,

Parit,

Gholap

et al. 2024

Preprint

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show abstract

“…The fabricated polymer-coated polymeric MN system was found to be useful in delivering lidocaine hydrochloride for 9 h through the skin and voriconazole for 6 h intravitreally [132] (Figure 14). release study revealed that the time required for the release of 50% dextran was 15 min; when PVP-K30 used, the time required was 20%.…”

Section: Intraocularmentioning

confidence: 99%

Section: Intraocularmentioning

confidence: 99%

Polymeric Microneedles: An Emerging Paradigm for Advanced Biomedical Applications

Kulkarni,

Gadade,

Chapaitkar

et al. 2023

Sci. Pharm.

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Microneedles are gaining popularity as a new paradigm in the area of transdermal drug delivery for biomedical and healthcare applications. Efficient drug delivery with minimal invasion is the prime advantage of microneedles. The concept of the microneedle array provides an extensive surface area for efficient drug delivery. Various types of inorganics (silicon, ceramic, metal, etc.) and polymeric materials are used for the fabrication of microneedles. The polymeric microneedles have various advantages over other microneedles fabricated using inorganic material, such as biocompatibility, biodegradation, and non-toxicity. The wide variety of polymers used in microneedle fabrication can provide a broad scope for drug delivery and other biomedical applications. Multiple metallic and polymeric microneedles can be functionalized by polymer coatings for various biomedical applications. The fabrication of polymeric microneedles is shifting from conventional to advanced 3D and 4D printing technology. The multifaceted biomedical applications of polymeric microneedles include drug delivery, vaccine delivery, biosensing, and diagnostic applications. Here, we provide the overview of the current and advanced information on polymers used for fabrication, the selection criteria for polymers, biomedical applications, and the regulatory perspective of polymer-based and polymer-coated microneedles, along with a patent scenario.

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Progress in the Application of Microneedles in Eye Disorders and the Proposal of the Upgraded Microneedle with Spinule

Yang,

Zhang,

et al. 2024

Pharm Res

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Polymer Coated Polymeric (PCP) Microneedles for Controlled Delivery of Drugs (Dermal and Intravitreal)

Cited by 16 publications

References 42 publications

Revolutionizing Eye Care: Exploring the Potential of Microneedle Drug Delivery

Revolutionizing Eye Care: Exploring the Potential of Microneedle Drug Delivery

Polymeric Microneedles: An Emerging Paradigm for Advanced Biomedical Applications

Progress in the Application of Microneedles in Eye Disorders and the Proposal of the Upgraded Microneedle with Spinule

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