Glazing systems play a significant role in managing the interaction between indoor and outdoor temperatures within a building. This research was conducted in a laboratory at Najran University in Saudi Arabia, focusing on six different glass samples, including two conventional (double low-E glass and vacuum clear glazing) and four smart glazing configurations (PDLC and SPD in both ON & OFF states), aiming to analyze their impact on indoor-outdoor temperature interaction, solar radiation control, and visual comfort. Key findings include SPD-OFF's superior temperature control (limiting increase to 24.28℃ compared to 10.53℃ for double low-E), PDLC-ON's optimal daylight illumination (2901.43 lux), and its higher energy efficiency (97.97 W/m² heat gain) compared to 44.8 W/m² for double low-E. The study also highlighted cost and environmental differences, with double low-E being the most cost-effective ($1.43/m² ) and PDLC-ON the most eco-friendly (14.5 kg CO2/m² ), despite higher operating costs. Overall, smart glazing systems, particularly the PDLC configuration, demonstrated notable advantages in thermal and visual comfort management.