Polymer–Magnesium Aluminum Silicate Composite Dispersions for Improved Physical Stability of Acetaminophen Suspensions

Puttipipatkhachorn, Satit

doi:10.1208/s12249-009-9215-4

Cited by 10 publications

(5 citation statements)

References 17 publications

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“…Thickness‐dependent diffusion constants are regularly reported and are generally attributed to a difference in density 18. 19 For the films studied herein, the PSII and PSIII films were prepared with respectively twice and four times the amount of material used for the PSI film. However, as can be seen from the thicknesses shown in Table 2, the thickness of the films increases more than linearly with the amount of material added.…”

Section: Resultsmentioning

confidence: 99%

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Biocatalytic and Structural Properties of a Highly Engineered Halohydrin Dehalogenase

et al. 2013

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Two highly engineered halohydrin dehalogenase variants were characterized in terms of their performance in dehalogenation and epoxide cyanolysis reactions. Both enzyme variants outperformed the wild-type enzyme in the cyanolysis of ethyl (S)-3,4-epoxybutyrate, a conversion yielding ethyl (R)-4-cyano-3-hydroxybutyrate, an important chiral building block for statin synthesis. One of the enzyme variants, HheC2360, displayed catalytic rates for this cyanolysis reaction enhanced up to tenfold. Furthermore, the enantioselectivity of this variant was the opposite of that of the wild-type enzyme, both for dehalogenation and for cyanolysis reactions. The 37-fold mutant HheC2360 showed an increase in thermal stability of 8 °C relative to the wild-type enzyme. Crystal structures of this enzyme were elucidated with chloride and ethyl (S)-3,4-epoxybutyrate or with ethyl (R)-4-cyano-3-hydroxybutyrate bound in the active site. The observed increase in temperature stability was explained in terms of a substantial increase in buried surface area relative to the wild-type HheC, together with enhanced interfacial interactions between the subunits that form the tetramer. The structures also revealed that the substrate binding pocket was modified both by substitutions and by backbone movements in loops surrounding the active site. The observed changes in the mutant structures are partly governed by coupled mutations, some of which are necessary to remove steric clashes or to allow backbone movements to occur. The importance of interactions between substitutions suggests that efficient directed evolution strategies should allow for compensating and synergistic mutations during library design.

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Section: Resultsmentioning

confidence: 99%

“…These diffusion coefficients generally increase with increasing film thickness 18. 19 Overall the fit is very good. As mentioned before, Equation (5) is only correct for small values of Dt / l ²; otherwise more terms would have to be introduced.…”

Section: Resultsmentioning

confidence: 99%

Biocatalytic and Structural Properties of a Highly Engineered Halohydrin Dehalogenase

et al. 2013

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“…All measurements were performed at a controlled temperature of 20 ± 1 C using spindle CP 52. The flow curve was plotted between shear rate and shear stress (Pongjanyakul and Puttipipatkhachorn, 2009).…”

Section: Rheological Studiesmentioning

confidence: 99%

Development of reconstitutable suspensions containing diclofenac sodium-loaded microspheres for pediatric delivery

Öz

Devrim

Bozkır

et al. 2015

Journal of Microencapsulation

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Effective clinical utilisation of non-steroidal anti-inflammatory drugs, such as diclofenac sodium (DS) is significantly limited by their ulcerogenic potential and poor bioavailability after oral administration. The objective of this work was to develop reconstitutable pediatric suspensions of DS-loaded microspheres prepared with an acrylic polymer (Eudragit RS) for improved pediatric delivery of DS. The microspheres were prepared by the water-in-oil-in-water or solid-in-oil-in-water emulsion techniques. Enviromental scanning electron microscopy observations clearly showed that microspheres have spherical shape. The drug entrapment efficiency of these microspheres was found 47.96 ± 0.79% to 88.57 ± 0.59% and their average particle sizes were 23.94-60.78 µm, which are within the desired range for the development of suspension formulation. The in vitro dissolution indicated prolonged sustained release of DS over 8 h. The results of preliminary characterisation studies of suspensions show that a liquid pharmaceutical preparation for oral administration capable of providing a sustained release of DS was successfully obtained.

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“…Owing to the large specific surface area, the synthetic clays possess more excellent viscoelasticity and thixotropy performance compared with Na-BT 25 . Therefore, they are usually applied to suspend and stabilize medicines and pigments 26,27 . Jiang et al…”

Section: Introductionmentioning

confidence: 99%

Enhanced foam-stabilizing performance by the addition of clays: A comparison of magnesium aluminum silicate with sodium bentonite

Wang

Yang

Jiang

et al. 2020

Applied Clay Science

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High-temperature-resistant foam stabilizers are desperately demanded for high-temperature conditions, such as geothermal well. In this study, nano-magnesium aluminum silicate (NMAS) and micro-magnesium aluminum silicate (MMAS) are initially studied and compared with sodium bentonite (Na-BT) as high-temperature-resistant foam stabilizers. We find that increasing temperature could facilitate aggregation of clay dispersion, and the increase of particle size results in significant positive effect on apparent viscosity (AV), interface dilational modulus (E), foam film thickness, and eventually drainage half-life (T 0.5 ) of the foam.Simultaneously, it leads to a negative impact on the initial foam volume (V 0 ) and

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Polymer–Magnesium Aluminum Silicate Composite Dispersions for Improved Physical Stability of Acetaminophen Suspensions

Cited by 10 publications

References 17 publications

Biocatalytic and Structural Properties of a Highly Engineered Halohydrin Dehalogenase

Biocatalytic and Structural Properties of a Highly Engineered Halohydrin Dehalogenase

Development of reconstitutable suspensions containing diclofenac sodium-loaded microspheres for pediatric delivery

Enhanced foam-stabilizing performance by the addition of clays: A comparison of magnesium aluminum silicate with sodium bentonite

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