Polymer matrices on the basis of polyacrylamide and β‐cyclodextrin‐containing pseudorotaxane for prolonged drug release: Synthesis and properties

Abstract

Polymer cross‐linked matrices based on polyacrylamide (PAA) and β‐cyclodextrin‐pseudorotaxane have been designed. The structure and properties of the objects synthesized were confirmed and studied by a series of methods, involving ultraviolet‐, Fourier transform infrared‐spectroscopy, thermal mass spectrometry, DSC, X‐ray diffraction analysis (WAXS and SAXS). Desorption kinetics (especially significant slowing of desorption process) of some drugs, like metoprolol succinate and loratadine from obtained polymer matrices is shown to be optimal with 10 wt% β‐CD‐pseudorotaxane in their structure.

Novel synthesis of N‐acrylamidociprofloxacin and related polymers: Bioactivity, drug resistance, and drug release

“…Therefore, it is urgently necessary to update the CF structure to resolve this increasingly prominent issue and develop efficient and inexpensive new derivatives of CF. [29][30][31] This importance derives from a world health organization (WHO) report 32 which indicates that the world is running out of antibiotics due to drug resistance. Therefore, it is necessary to update the antibiotic structure which will assist in reducing the risk of antibiotic threats globally.…”

“…Although CF is an extensively used antibiotic, bacterial resistance can emerge, which may pose a potential threat to human health. Therefore, it is urgently necessary to update the CF structure to resolve this increasingly prominent issue and develop efficient and inexpensive new derivatives of CF 29–31 . This importance derives from a world health organization (WHO) report 32 which indicates that the world is running out of antibiotics due to drug resistance.…”

Alkaline media‐sensitive nanocarrier based on carboxylated cyclodextrin for targeted delivery of anti‐colon drug

“…Cyclodextrins (CDs), as a class of α-1,4-linked cyclic oligosaccharides, [24][25][26] are ideal blocks for the construction of drug-carriers due to CDs are flexible to construct the self-assemblies with various guest substrates based on noncovalent interactions, as well as exhibit good water solubility and biocompatibility. [27][28][29][30] Meanwhile, CDs could be specifically degraded into small molecules by glycosidases existing in the colon, 27 thus, they have important application value in the targeted delivery and release of anti-colon drugs.…”

A dual‐stimuli responsive supramolecular nanovector anchoring folic acid ligands for targeted delivery of anti‐colorectal drug hydroxycamptothecin

“…24 Supramolecular nanocarriers are capable of responding to a variety of external stimuli by bonding multiple guest groups through non-covalent bonding force and are therefore an important component of DDSs. 25 Cyclodextrins (CDs), a class of naturally cyclic oligosaccharides with high tunability and biocompatibility 26 are attractive constructs for the design of supramolecular nanocarriers. 27 Functionalized CDs have been widely explored as multiple-stimuli responsive nanodrug carriers for potential cancer treatment.…”