Polymer/metal composite 3D porous bone tissue engineering scaffolds fabricated by additive manufacturing techniques: A review

Zerankeshi, Meysam Mohammadi; Bakhshi, Rasoul; Alizadeh, Reza

doi:10.1016/j.bprint.2022.e00191

Cited by 69 publications

(33 citation statements)

References 69 publications

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“…They have emerged as some of the competitive wound dressing candidates. They are hydrophilic and biocompatible and have a three-dimensional porous structure similar to the extracellular matrix. , It has also piqued the interest of several researchers. The study has also increased hydrogels as wound dressings, particularly in the last decade.…”

Section: Introductionmentioning

confidence: 99%

Role of Graphene Oxide in Bacterial Cellulose−Gelatin Hydrogels for Wound Dressing Applications

et al. 2023

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Biopolymer-based hydrogels have several advantages, including robust mechanical, high biocompatibility, and excellent properties. These hydrogels can be ideal wound dressing materials and advantageous to repair and regenerate skin wounds. In this work, we have reported fabricated of composite hydrogels from gelatin and graphene oxide-f unctionalized-bacterial cellulose (synthesized by hydrothermal method) (GO-f-BC) and crosslinked with tetraethyl orthosilicate (TEOS). The hydrogels were characterized using Fourier transform infrared spectroscopy, scanning electron microscopy, atomic force microscopy, and water contact angle analyses to explore functional groups and their interactions, surface morphology, and wetting behavior, respectively. The swelling, biodegradation, and water retention were tested to respond to biofluid. Maximum swelling was exhibited by samle with maximum amount of GO (GBG-4) in all media (aqueous = 1902.83%, PBS = 1546.63%, and electrolyte = 1367.32%). The hemolysis of all hydrogel samples is less than 0.5%, and the blood coagulation time decreased as the hydrogel concentration increased. The composite hydrogels were found to be hemocompatible as they have less than 0.5% hemolysis for all hydrogel samples under in vitro standard conditions. These hydrogels performed unusual antimicrobial activities against Gram (positive and negative) bacterial strains. The cell viability and proliferation were increased with an increased GO amount, and maximum values were found for GBG-4 against fibroblast (3T3) cell lines. The mature and well-adhered cell morphology of 3T3 cells was found against all hydrogel samples. Hence, based on these results findings, these hydrogels would be potential wound dressing skin materials for wound healing applications.

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Section: Introductionmentioning

confidence: 99%

Role of Graphene Oxide in Bacterial Cellulose−Gelatin Hydrogels for Wound Dressing Applications

et al. 2023

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“…Polylactic acid (PLA) [ 15 , 16 ], poly (lactic-co-glycolic acid) (PLGA) [ 17 ], polycaprolactone (PCL) [ 18 ], and polyether ether ketone (PEEK) [ 19 ] are FDA-approved biomaterials [ 20 ]. These materials possess significant mechanical properties comparable to the natural bone; therefore, they can act as load-bearing prosthetic elements [ 21 ]. Polyetherimide (PEI) is another biocompatible material under investigation for biomedical applications due to its excellent physical, chemical, and mechanical properties [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Material Extrusion 3D Printing (ME3DP) Process Simulations of Polymeric Porous Scaffolds for Bone Tissue Engineering

2023

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Bone tissue engineering (BTE) is an active area of research for bone defect treatment. Some polymeric materials have recently gained adequate attention as potential materials for BTE applications, as they are biocompatible, biodegradable, inexpensive, lightweight, easy to process, and recyclable. Polyetherimide (PEI), acrylonitrile butadiene styrene (ABS), and polyamide-12 (PA12) are potential biocompatible materials for biomedical applications due to their excellent physical, chemical, and mechanical properties. The current study presents preliminary findings on the process simulations for 3D-printed polymeric porous scaffolds for a material extrusion 3D printing (ME3DP) process to observe the manufacturing constraints and scaffold quality with respect to designed structures (porous scaffolds). Different unit cell designs (ventils, grid, and octet) for porous scaffolds, virtually fabricated using three polymeric materials (PEI, ABS, and PA12), were investigated for process-induced defections and residual stresses. The numerical simulation results concluded that higher dimensional accuracy and control were achieved for grid unit cell scaffolds manufactured using PEI material; however, minimum residual stresses were achieved for grid unit cell scaffolds fabricated using PA12 material. Future studies will include the experimental validation of numerical simulation results and the biomechanical performance of 3D-printed polymeric scaffolds.

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“…Further, the mechanical strength is reduced, and the degradation rate is according to the osteogenesis rate, leading to pH modifications of the adjacent environment, generated by degradation products. On the other hand, even though bioceramics have good bone conductivity and biocompatibility, there is still a problem regarding the low toughness and significant brittleness that leads to damage and poor use reliability [ 5 , 6 ]. The limitations mentioned above have been addressed by developing biomaterials characterized by biomimicry and tissue regeneration capacity.…”

Section: Introductionmentioning

confidence: 99%

Novel Trends into the Development of Natural Hydroxyapatite-Based Polymeric Composites for Bone Tissue Engineering

et al. 2022

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In recent years, the number of people needing bone replacements for the treatment of defects caused by chronic diseases or accidents has continuously increased. To solve these problems, tissue engineering has gained significant attention in the biomedical field, by focusing on the development of suitable materials that improve osseointegration and biologic activity. In this direction, the development of an ideal material that provides good osseointegration, increased antimicrobial activity and preserves good mechanical properties has been the main challenge. Currently, bone tissue engineering focuses on the development of materials with tailorable properties, by combining polymers and ceramics to meet the necessary complex requirements. This study presents the main polymers applied in tissue engineering, considering their advantages and drawbacks. Considering the potential disadvantages of polymers, improving the applicability of the material and the combination with a ceramic material is the optimum pathway to increase the mechanical stability and mineralization process. Thus, ceramic materials obtained from natural sources (e.g., hydroxyapatite) are preferred to improve bioactivity, due to their similarity to the native hydroxyapatite found in the composition of human bone.

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Polymer/metal composite 3D porous bone tissue engineering scaffolds fabricated by additive manufacturing techniques: A review

Cited by 69 publications

References 69 publications

Role of Graphene Oxide in Bacterial Cellulose−Gelatin Hydrogels for Wound Dressing Applications

Role of Graphene Oxide in Bacterial Cellulose−Gelatin Hydrogels for Wound Dressing Applications

Material Extrusion 3D Printing (ME3DP) Process Simulations of Polymeric Porous Scaffolds for Bone Tissue Engineering

Novel Trends into the Development of Natural Hydroxyapatite-Based Polymeric Composites for Bone Tissue Engineering

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