Polymer nanotherapeutics: A versatile platform for effective rheumatoid arthritis therapy

Nooreen, Rimsha; Nene, Shweta; Jain, Harsha; Prasannanjaneyulu, Velpula; Chitlangya, Palak; Otavi, Shivam; Khatri, Dharmendra Kumar; Raghuvanshi, Rajeev Singh; Singh, Shashi Bala; Srivastava, Saurabh

doi:10.1016/j.jconrel.2022.05.054

Cited by 21 publications

(2 citation statements)

References 174 publications

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“…6,7 Various nanocarriers such as liposomes, dendrimers, microemulsions, nanoparticles, and micelles have been used for RA treatment. [8][9][10] Anti-rheumatic drugs encapsulated in nanocarriers can passively accumulate in chronic inflammatory tissues through extravasation via the leaky vasculature and subsequent inflammatory cell-mediated sequestration (ELVIS) effect, because the interendothelial cell gaps of inflamed joints can be up to 600 nm. 11 The ELVIS effect resembles the enhanced permeability and retention (EPR) effect in solid tumors.…”

Section: Introductionmentioning

confidence: 99%

Combined ROS Sensitive Folate Receptor Targeted Micellar Formulations of Curcumin Effective Against Rheumatoid Arthritis in Rat Model

Wang,

Guo,

Zou

et al. 2024

IJN

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Rheumatoid arthritis (RA) is an inflammatory immune-mediated disease that involves synovitis, cartilage destruction, and even joint damage. Traditional agents used for RA therapy remain unsatisfactory because of their low efficiency and obvious adverse effects. Therefore, we here established RA microenvironment-responsive targeted micelles that can respond to the increase in reactive oxygen species (ROS) levels in the joint and improve macrophage-specific targeting of loaded drugs. Methods: We here prepared ROS-responsive folate-modified curcumin micelles (TK-FA-Cur-Ms) in which thioketal (TK) was used as a ROS-responsive linker for modifying polyethylene glycol 5000 (PEG 5000 ) on the micellar surface. When micelles were in the ROS-overexpressing inflammatory microenvironment, the PEG 5000 hydration layer was shed, and the targeting ligand FA was exposed, thereby enhancing cellular uptake by macrophages through active targeting. The targeting, ROS sensitivity and anti-inflammatory properties of the micelles were assessed in vitro. Collagen-induced arthritis (CIA) rats model was utilized to investigate the targeting, expression of serum inflammatory factors and histology change of the articular cartilage by micelles in vivo. Results: TK-FA-Cur-Ms had a particle size of 90.07 ± 3.44 nm, which decreased to 78.87 ± 2.41 nm after incubation with H 2 O 2 . The micelles exhibited in vitro targeting of RAW264.7 cells and significantly inhibited inflammatory cytokine levels. Pharmacodynamic studies have revealed that TK-FA-Cur-Ms prolonged the drug circulation and exhibited augmented cartilage-protective and antiinflammatory effects in vivo. Conclusion:The unique ROS-responsive targeted micelles with targeting, ROS sensitivity and anti-inflammatory properties were successfully prepared and may offer an effective therapeutic strategy against RA.

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Section: Introductionmentioning

confidence: 99%

Combined ROS Sensitive Folate Receptor Targeted Micellar Formulations of Curcumin Effective Against Rheumatoid Arthritis in Rat Model

Wang,

Guo,

Zou

et al. 2024

IJN

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“…[4][5][6] Although the cause of RA is complicated, several classes of drugs are commonly used in clinical practice, to control the development of the disease and reduce joint damage such as nonsteroidal anti-inflammatory drugs (NSAIDs), disease-modifying antirheumatic drugs (DMARDs), immunosuppressive drugs, biological agents, small interfering RNA (siRNA), and natural small-molecule compounds. 7,8 Although the above-mentioned drugs have some therapeutic effects, they still have some disadvantages including the need for high doses, poor patient compliance, less drug accumulation in joints, and extraarticular adverse reactions. In addition, most drugs through intravenous/intra-articular injection have lower bioavailability and faster systemic clearance.…”

Section: Introductionmentioning

confidence: 99%

Advances in Formulations of Microneedle System for Rheumatoid Arthritis Treatment

Guo,

Huang,

Yang

et al. 2023

IJN

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Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic joint inflammation, eventually leading to severe disability and premature death. At present, the treatment of RA is mainly to reduce inflammation, swelling, and pain. Commonly used drugs are non-steroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, and disease-modifying anti-rheumatic drugs (DMARDs). These drugs lack specificity and require long-term, high-dose administration, which can cause serious adverse effects. In addition, the oral, intravenous, and intra-articular injections will reduce patient compliance, resulting in high cost and low bioavailability. Due to these limitations, microneedles (MNs) have emerged as a new strategy to efficiently localize the drugs in inflamed joints for the treatment of RA. MNs can overcome the cuticle barrier of the skin without stimulating nerves and blood vessels. Which can increase patient compliance, improve bioavailability, and avoid systemic circulation. This review summarizes and evaluates the application of MNs in RA, especially dissolving MNs (DMNs). We encourage the use of MNs to treat RA, by describing the general properties of MNs, materials, preparation technology, drug release mechanism, and advantages. Furthermore, we discussed the biological safety, development prospects, and future challenges of MNs, hoping to provide a new strategy for the treatment of RA.

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Use of toxicokinetic data in preclinical safety assessment

Kaur,

Tekade,

Vasdev

et al. 2024

Public Health and Toxicology Issues Drug Research, Volume 2

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Polymer nanotherapeutics: A versatile platform for effective rheumatoid arthritis therapy

Cited by 21 publications

References 174 publications

Combined ROS Sensitive Folate Receptor Targeted Micellar Formulations of Curcumin Effective Against Rheumatoid Arthritis in Rat Model

Combined ROS Sensitive Folate Receptor Targeted Micellar Formulations of Curcumin Effective Against Rheumatoid Arthritis in Rat Model

Advances in Formulations of Microneedle System for Rheumatoid Arthritis Treatment

Use of toxicokinetic data in preclinical safety assessment

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