Polymer nanowell plates with variable well slope angles

Becker, Holger; Klotzbücher, T.

doi:10.1007/978-3-642-59738-1_10

Cited by 4 publications

(7 citation statements)

References 9 publications

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“…The mask defines the ablated region, while the complete pattern is made by moving the substrate on the x-y stage underneath the mask. Depending on the energy available per laser pulse and on the substrate material, typical ablation rates per laser pulse range between some hundred nanometers [49,50] and 5 mm [49]. With this technology, a wide range of polymeric materials, including PMMA, PS, PC polyethyleneterephthalate (PET), cellulose acetate, polyimide and photoresists have been structured [47±50].…”

Section: Laser-based Technologiesmentioning

confidence: 99%

Polymer microfabrication methods for microfluidic analytical applications

Becker

Gärtner²

2000

Electrophoresis

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739

405

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A growing number of microsystem technology (MST) applications, particularly in the field of microfluidics with its applications in the life sciences, have a need for novel fabrication methods which account for substrates other than silicon or glass. We present in this paper an overview of existing polymer microfabrication technologies for microfluidic applications, namely replication methods such as hot embossing, injection molding and casting, and the technologies necessary to fabricate the molding masters. In addition, techniques such as laser ablation and layering techniques are examined. Methods for bonding and dicing of polymer materials, which are necessary for complete systems, are evaluated.

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Section: Laser-based Technologiesmentioning

confidence: 99%

Polymer microfabrication methods for microfluidic analytical applications

Becker

Gärtner²

2000

Electrophoresis

Self Cite

739

405

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“…This enables the creation of polymer-based microfluidic structures [103,104]. The depth and width of the channels are adjusted by the laser intensity and repetition of the beam exposure along the same channel.…”

Section: Laser Ablation Micromachiningmentioning

confidence: 99%

“…Depending on the energy per laser pulse and the material of the used substrate, the ablation rates per pulse are about 0.1-5 μm [103,104]. Ranges of polymeric material have been used with this method, including PMMA, PS, PC (PET) [105,106].…”

Section: Laser Ablation Micromachiningmentioning

confidence: 99%

Polymer-Based Microfluidic Devices for Pharmacy, Biology and Tissue Engineering

2012

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This paper reviews microfluidic technologies with emphasis on applications in the fields of pharmacy, biology, and tissue engineering. Design and fabrication of microfluidic systems are discussed with respect to specific biological concerns, such as biocompatibility and cell viability. Recent applications and developments on genetic analysis, cell culture, cell manipulation, biosensors, pathogen detection systems, diagnostic devices, high-throughput screening and biomaterial synthesis for tissue engineering are presented. The pros and cons of materials like polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), polystyrene (PS), polycarbonate (PC), cyclic olefin copolymer (COC), glass, and silicon are discussed in terms of biocompatibility and fabrication aspects. Microfluidic devices are widely used in life sciences. Here, commercialization and research trends of microfluidics as new, easy to use, and cost-effective measurement tools at the cell/tissue level are critically reviewed.

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“…This concept could be applied to the area of combinatorial generation of substances and compounds or to the area of micrototal analysis systems (μTAS). 10 In μTAS concepts, the only step carried out outside the microdevice environment is the addition of sample and reagents. Other necessary steps for total analysis might involve analyte isolation, concentration, dilution, amplification, labeling, or incubation.…”

Section: Microreactorsmentioning

confidence: 99%

“…Figure 9 provides SEM images of nanowell crossections and top geometry in a process initiated with the microfabrication of a master using UV-LIGA ablation of PMMA coated over a titanium wafer. 14,15 In the study by Becker and Klotzbücher 10 , the careful selection of the Excimer ablation parameters permitted the generation of very smooth microfabricated surfaces defining the wells. Furthermore, it permitted the control of the slope of the wall at 45–90 degrees for the nanowell as a means to affect the dispensing of liquids and microparticles into the nanowells for the intended functionality of these microarrays.…”

Section: Microarraysmentioning

confidence: 99%

Polymer Microfabrication for Microarrays, Microreactors and Microfluidics

Alonso-Amigo¹

2000

JALA: Journal of the Association for Laboratory Automation

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Polymer microfabrication methods are becoming increasingly important as low-cost alternatives to the silicon or glass-based MEMS technologies. Polymer hot embossing and injection molding are replication methods applicable to microreplication of a diversity of materials and microstructures. Equipment with high precision control of pressure and temperature for hot embossing of polymer materials is now available commercially. These systems have made possible the replication of chips containing microchannels for capillary electrophoresis (CE) and microfluidics devices, microoptical components and microreactors. Stable and reproducible polymer microstructures have been demonstrated in several types of materials with structural and optical properties meeting other biocompatibility and detection requirements. The process involves few variable parameters and results in high structural accuracy suited for a wide range of microfabrication applications. After demonstrating equivalent and, in cases, improved performance, the alternative use of plastic as the microdevice material addresses needs for rapid prototyping in product development and provides cost advantages in product commercialization. Thus an increasing number of devices have been reported recently in the literature, fabricated on a variety of polymer substrates and using different fabrication methods such as laser ablation, injection molding, silicone rubber casting or embossing for microfabrication.

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Polymer nanowell plates with variable well slope angles

Cited by 4 publications

References 9 publications

Polymer microfabrication methods for microfluidic analytical applications

Polymer microfabrication methods for microfluidic analytical applications

Polymer-Based Microfluidic Devices for Pharmacy, Biology and Tissue Engineering

Polymer Microfabrication for Microarrays, Microreactors and Microfluidics

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