Nanomaterials are applied with great success
in biomedical applications as templates for the development
of new generation devices, which can be used to
solve current health problems. These new nanoscale systems
are designed with multifunctions to perform specific
and selective tasks. One of the most important applications
of this new nanotechnology; focuses on developing
new systems for the controlled release of drugs, mainly
due to their capability to improve the temporal and spatial
presentation of drugs in the body and their ability to
protect them from physiological degradation or elimination.
Hydrogels, porous silicon (PSi), and PSi-composites
have been widely adopted in this field due to their biological,
morphological, and physicochemical properties;
which can be tuned to obtain sensitive responses to physiological
stimuli. Despite the fact that some recent academic
papers have shown the benefits of these nanomaterials
in a wide range of biological applications, more in
vivo studies are needed to take these hybrid systems towards
clinical trials. In this mini-review some of the hydrogels,
PSi, and PSi-composites latest applications and
prospects in this field of science are presented.