2023
DOI: 10.1002/marc.202300438
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Polymer–Protein Nanovaccine Synthesized via Reactive Self‐Assembly with Potential Application in Cancer Immunotherapy: Physicochemical and Biological Characterization In Vitro and In Vivo

Mingming Zhang,
Wenjuan Chen,
Yuanyuan Ju
et al.

Abstract: Nanovaccines composed of polymeric nanocarriers and protein‐based antigens have attracted much attention in recent years because of their enormous potential in the prevention and treatment of diseases such as viral infections and cancer. While surface‐conjugated protein antigens are known to be more immunoactive than encapsulated antigens, current surface conjugation methods often result in low and insufficient protein loading. Here, we use reactive self‐assembly to prepare nanovaccine from poly(ε‐caprolactone… Show more

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