Polymer Vesicles Containing Small Vesicles within Interior Aqueous Compartments and pH‐Responsive Transmembrane Channels

Chiu, Hsin‐Cheng; Lin, Yi-Shiuan; Huang, Yi‐Fong; Chuang, Chih‐Kai; Chern, Chorng–Shyan

doi:10.1002/anie.200704078

Cited by 197 publications

(120 citation statements)

References 36 publications

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“…Moreover, targeted transport can be achieved by taking advantage of the many possibilities to endfunctionalize the copolymers (5). The controlled release of therapeutic substances can also be integrated through the use of copolymers with blocks that respond to chemical stimuli such as hydrolysis (6,7), oxidation (8) or reduction (9) reaction, and pH changes (10)(11)(12)(13)(14)(15)(16)(17). Common strategies have been to use hydrophobic blocks that can progressively degrade or convert into hydrophilic moieties or to use a cleaveable linkage between hydrophobic and hydrophilic blocks.…”

mentioning

confidence: 99%

Bursting of sensitive polymersomes induced by curling

Mabrouk

Cuvelier

Brochard‐Wyart

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

177

152

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Polymersomes, which are stable and robust vesicles made of block copolymer amphiphiles, are good candidates for drug carriers or micro/nanoreactors. Polymer chemistry enables almost unlimited molecular design of responsive polymersomes whose degradation upon environmental changes has been used for the slow release of active species. Here, we propose a strategy to remotely trigger instantaneous polymersome bursting. We have designed asymmetric polymer vesicles, in which only one leaflet is composed of responsive polymers. In particular, this approach has been successfully achieved by using a UV-sensitive liquid-crystalline copolymer. We study experimentally and theoretically this bursting mechanism and show that it results from a spontaneous curvature of the membrane induced by the remote stimulus. The versatility of this mechanism should broaden the range of applications of polymersomes in fields such as drug delivery, cosmetics and material chemistry.asymmetric polymer vesicles ͉ liquid-crystalline copolymer ͉ spontaneous curvature ͉ UV-sensitive

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mentioning

confidence: 99%

Bursting of sensitive polymersomes induced by curling

Mabrouk

Cuvelier

Brochard‐Wyart

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

177

152

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“…For vesicles formed from a PAA-b-PBD diblock copolymer in water, Discher's group (Geng et al 2005) observed that a sudden increase in pH induced the rapid (~min-utes) transition of vesicles into worms and spheres. Chiu's group has recently reported an interesting work on polymersomes with pH-responsive transmembrane channels (Chiu et al 2008). The copolymers used to form vesicles were not block copolymers but rather random copolymers of acrylic acid (AAc) and distearin acrylate (DSA), that were obtained from partial transesterification of poly(N-acryloxysuccinimide) (poly(NAS)) with distearin (a lipid graft) followed by thorough hydrolysis of the un-reacted NAS to AAc units.…”

Section: Ph Responsive Polymersomes Formed From Synthetic Block Copolmentioning

confidence: 99%

Stimuli-Responsive Polymersomes

2011

Intracellular Delivery

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Polymer vesicles, commonly called polymersomes, are spherical shell structures in which an aqueous compartment is enclosed by a bilayer membrane made from amphiphilic block copolymers. Compared to liposomes, their low molecular weight analogues, polymersomes have many superior properties (higher toughness, better stability, tailorable membrane properties), which make them attractive candidates for applications including drug delivery, diagnosis, nanoreactors and templates for micro-or nano-structured materials. Many potential applications require the ability to control the release of substances encapsulated in the interior compartment and /or in the hydrophobic core of membrane. To address this goal, polymersomes have been developed in which a specific stimulus destabilises the vesicular structure. The responsiveness is mainly achieved via proper hydrophobic block design. In this chapter we review the most promising approaches to make stimuli-responsive polymersomes that permit the controlled release of encapsulated contents. Chemical stimuli including hydrolysis, oxidation, reduction and pH change, and physical stimuli including temperature, light, magnetic field, electric field, osmotic shock and ultrasonic wave are discussed, on emphasizing their effects on the chemical and physical structure of the amphiphilic copolymers.

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“…[24] In a study by Chiu et al, pH-responsive acrylic acid (AAc) channels were arranged in the vesicle membrane and the open or the closed state of the channels could be controlled by adjusting the pH value of the aqueous solution. [26] Similarly, bacterial pore proteins were set throughout the vesicles and an intelligent nanometer-scale sensoreffector was built by Hunziker and co-workers. [27] The bacterial channel forming protein, LamB could also be constituted in ABA-triblock copolymer vesicles.…”

Section: Introductionmentioning

confidence: 99%

Nanometer‐Scaled Hollow Spherical Micelles with Hydrophilic Channels and the Controlled Release of Ibuprofen

Xiong

et al. 2008

Macromol. Rapid Commun.

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PS‐b‐PAA spherical micelles with a liquid core and a PAA shell are prepared with the assistance of 1,2‐dichloroethane. During the process of adding a mixture of PNIPAM‐b‐P4VP and PEG‐b‐P4VP, multi‐layered micelles with a mixed corona that consists of both PNIPAM and PEG chains are constructed through the electrostatic interaction and hydrogen bonding between the PAA block and the P4VP block. When heating above the LCST, the PNIPAM chains collapse onto the PAA/P4VP complex layer while the PEG chains still stretch into the solution through the collapsed PNIPAM layer, which leads to the formation of hydrophilic channels around the PEG chains. The ibuprofen encapsulated in the hollow space can diffuse through the channels and its release rate can be controlled by changing the ratio of PEG chains to PNIPAM chains in the corona.

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Polymer Vesicles Containing Small Vesicles within Interior Aqueous Compartments and pH‐Responsive Transmembrane Channels

Cited by 197 publications

References 36 publications

Bursting of sensitive polymersomes induced by curling

Bursting of sensitive polymersomes induced by curling

Stimuli-Responsive Polymersomes

Nanometer‐Scaled Hollow Spherical Micelles with Hydrophilic Channels and the Controlled Release of Ibuprofen

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