Polymer Vesicles with Upper Critical Solution Temperature for Near-infrared Light-triggered Transdermal Delivery of Metformin in Diabetic Rats

Living symbiotic bacteria-involved skin dressing to combat indigenous pathogens for microbiome-based biotherapy toward atopic dermatitis

“…mucosa , PVP, PVA and SA. PVP and PVA have been widely used as restorative materials because they offer a physiologically benign environment for cell proliferation and migration [ [37] , [38] , [39] , [40] ]. In addition, PVA is up to date the only one among vinyl polymers suited as a carbon and energy source for bacteria [ [41] , [42] , [43] ].…”

Poly(N-acryloyl glycinamide-co-N-acryloxysuccinimide) Nanoparticles: Tunable Thermo-Responsiveness and Improved Bio-Interfacial Adhesion for Cell Function Regulation

“…These could be attributed to the combination of NAGA–NAGA H-bonding, NAGA–NAS H-bonding, and hydrophobic interactions of NAS, as illustrated in Scheme . The obtained UCST PNPs thereby can be developed into molecular switches and find applications in thermo-sensitive drug carriers or catalyst modulations. − …”

“…At a low concentration (<2 wt %), PNAGA exhibits upper critical solution temperature (UCST) behavior − and performs a thermo-reversible transition between two states: nanoparticles and soluble chains. ,− At a medium concentration (2–10 wt %), PNAGA forms hydrogels and exhibits a thermo-reversible gel–sol transition. , At a high concentration (>10 wt %), PNAGA forms hydrogels with high mechanical properties as a result of hydrophobic micro-domain formation that is driven by intermolecular H-bonds. − Besides, excellent biocompatibility has also been reported of PNAGA. , Thus, PNAGA-based polymers have been developed for biomedical applications, such as for in vivo drug delivery − or cell adhesion modulation − or as self-healing hydrogels ,− or ultralow fouling surfaces . However, these developments mainly focused on using PNAGA as hydrogels. − Investigations based on PNAGA as thermo-responsive nanoparticles are few, and so far ,only PNAGA as temperature-sensitive drug carriers or enzyme switches , have been reported. Considering that the nanoparticle bio-interfaces can produce diverse biological outcomes, addressing two key issues is important to expand the applications of PNAGA nanoparticles in biomedical fields.…”

“…24 However, these developments mainly focused on using PNAGA as hydrogels. 25−28 Investigations based on PNAGA as thermo-responsive nanoparticles are few, and so far ,only PNAGA as temperature-sensitive drug carriers 29 or enzyme switches 30,31 have been reported.…”

Glucose-sensitive poly(ether sulfone) composite membranes blended with phenylboronic acid-based amphiphilic block copolymer for self-regulated insulin release

“…Compared with microgels, amphiphilic block copolymers as functional blend modifiers have gained increasing attention. 16–21 Herein, amphiphilic block copolymer polystyrene- b -poly( N -isopropylacrylamide- co -2-(acrylamido) phenylboronic acid) (PSNB) and poly(ether sulfone) (PES) were blended to prepare glucose-sensitive membrane. During the non-solvent induced phase separation (NIPS) process, amphiphilic polymers can be enriched at the interface between water and the membrane matrix.…”