Polymerase chain reaction in clinically suspected genitourinary tuberculosis: comparison with intravenous urography, bladder biopsy, and urine acid fast bacilli culture

Hemal, Ashok K.; Gupta, Nidhi; Rajeev, T P; Kumar, Rajeev; Dar, Lalit; Seth, Pradeep

doi:10.1016/s0090-4295(00)00668-3

Cited by 118 publications

(98 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…TB prevalence was 30% (SD 24) ( Table 69). Three of the nine data sets were from laboratorybased studies and one 229 used a combined culture plus clinical diagnosis reference standard. Two studies reported using blinded test interpretation; this information was not reported in the others.…”

Section: Nucleic Acid Amplification Testsmentioning

confidence: 99%

“…229 The sample was judged to be unrepresentative and binding and study design could not be determined. TB prevalence was 70%.…”

Section: Antigen Testsmentioning

confidence: 99%

“…Both statistical tests for heterogeneity were statistically significant (p < 0.01) ( Table 70 Table 71). The single study meeting all five design-related criteria 229 found an in-house NAAT using the MPB64 target sequence to have a sensitivity of 94% and a specificity 86%, but only 42 patients were included and prevalence was high (83%) ( Table 71). …”

Section: Nucleic Acid Amplification Testsmentioning

confidence: 99%

See 2 more Smart Citations

A systematic review of rapid diagnostic tests for the detection of tuberculosis infection

Dinnes¹,

Deeks²,

Kunst³

et al. 2007

Health Technol Assess

538

361

View full text Add to dashboard Cite

Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. NHS libraries can subscribe free of charge. Public libraries can subscribe at a very reduced cost of £100 for each volume (normally comprising 30-40 titles). The commercial subscription rate is £300 per volume. Please see our website for details. Subscriptions can only be purchased for the current or forthcoming volume. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment ProgrammeT he Health Technology Assessment (HTA) programme, now part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the costs, effectiveness and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined to include all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care, rather than settings of care. The research findings from the HTA Programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service'. The HTA Programme is needs-led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects. First is the commissioned route. Suggestions for research are actively sought from people working in the NHS, the public and consumer groups and professional bodies such as ...

show abstract

Section: Nucleic Acid Amplification Testsmentioning

confidence: 99%

“…229 The sample was judged to be unrepresentative and binding and study design could not be determined. TB prevalence was 70%.…”

Section: Antigen Testsmentioning

confidence: 99%

Section: Nucleic Acid Amplification Testsmentioning

confidence: 99%

See 1 more Smart Citation

A systematic review of rapid diagnostic tests for the detection of tuberculosis infection

Dinnes¹,

Deeks²,

Kunst³

et al. 2007

Health Technol Assess

538

361

View full text Add to dashboard Cite

show abstract

“…About 8-15% of patients with pulmonary tuberculosis develop urinary tuberculosis [3]. Classically the bladder has been called the "sounding board" for the diagnosis of urinary tuberculosis.…”

Section: Discussionmentioning

confidence: 99%

Genito-Urinary Tuberculosis – A Great Mimicker and Its Atypical Manifestations: An Interesting Case Series

Krishnamoorthy¹

2017

Austin J Urol

View full text Add to dashboard Cite

Tuberculosis continues to be a major health problem in the developing world. Renal tuberculosis is the most common site of extra -pulmonary tuberculosis. It comprises 20% of all extra pulmonary tuberculosis. The accurate incidence and prevalence of Genito Urinary Tuberculosis (GUTB) is difficult to be figured out because a very large varieties of atypical presentations. It is often called as a "Great Mimicker" because of the variety of other conditions that it might mimic. A vast majority of patients remain asymptomatic and present in late stages as the disease is not thought of in these asymptomatic patients. Moreover the urine can become sterilized relatively rapidly after the initiation of chemotherapy, further adding on to the diagnostic difficulties.In this manuscript, we report a series of GUTB cases that presented in an atypical manner, causing diagnostic and management dilemma. The purpose of this manuscript is to highlight the variety of atypical manifestations of GUTB and also to stress on the need for a high index of clinical suspicion in identifying such cases at an earlier stage in order to prevent the disease from progressing to non-salvageable state.

show abstract

“…35 In the present study, PCR exhibited greater sensitivity than microscopy and the culture, and could facilitate therapeutic decisions for patients with a clinical suspicion of ETB; as was found by other authors. [36][37][38] For diagnosis of GUTB, although a high index for clinical suspicion is necessary, 39 PCR can be useful for cases in which bacteriologic and clinical diagnoses of TB are not conclusive. 40 We found PCR to be a very rapid diagnostic method for GUTB.…”

Section: Discussionmentioning

confidence: 99%

Clinical usefulness of the nested polymerase chain reaction in the diagnosis of extrapulmonary tuberculosis

García-Elorriaga¹,

Gracida-Osorno²,

Carrillo-Montes³

et al. 2009

Salud pública Méx

View full text Add to dashboard Cite

Objective. To evaluate the effectiveness of nested polymerase chain reaction (PCR) for diagnosis of extrapulmonary tuberculosis (ETB), as well as the impact of PCR results on clinical management. Materials and Methods. We conducted a study of nested PCR tests in 45 patients and a review of patient hospital files, calculating sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Results. PCR was positive in 51% of cases; PCR sensitivity for diagnosing TB was 86%, specificity was 79%, PPV was 76%, and NPV was 88%. When solely analyzing urine samples, sensitivity and NPV increased to 100%. PCR exerted an influence on management in 27% of patients. Conclusions. PCR for rapid diagnosis of extrapulmonary TB has an adequate effect, which improves when performed on urine. The results of PCR exerted an acceptable impact on the clinical management of these patients.Key words: tuberculosis; extrapulmonary tuberculosis; polymerase chain reaction; nested polymerase chain reaction ResumenObjetivo. Evaluar la eficacia de la reacción en cadena de la polimerasa (PCR) anidada para el diagnóstico de tuberculosis extrapulmonar, así como el impacto de sus resultados en el manejo clínico. Material y métodos. Se realizó PCR anidada en 45 pacientes y se llevó a cabo la revisión de expedientes. Se calculó sensibilidad, especificidad, valor predictivo positivo (VPP) y valor predictivo negativo (VPN). Resultados. La PCR fue positiva en 51% de los casos, la sensibilidad fue de 86%, la especificidad de 79%, el VPP de 76% y el VPN de 88%. Al analizar solamente las muestras de orina, la sensibilidad y VPN se incrementaron a 100%. La PCR influyó en el manejo de 27% de los pacientes. Conclusiones. La PCR para el diagnóstico rápido de TB extrapulmonar tiene una eficacia adecuada, la cual mejora cuando se realiza en orina. El resultado de la PCR tuvo un impacto aceptable en el manejo clínico de estos pacientes.Palabras clave: tuberculosis; tuberculosis extrapulmonar; reacción en cadena de la polimerasa; reacción en cadena de la polimerasa anidada (

show abstract

Polymerase chain reaction in clinically suspected genitourinary tuberculosis: comparison with intravenous urography, bladder biopsy, and urine acid fast bacilli culture

Cited by 118 publications

References 15 publications

A systematic review of rapid diagnostic tests for the detection of tuberculosis infection

A systematic review of rapid diagnostic tests for the detection of tuberculosis infection

Genito-Urinary Tuberculosis – A Great Mimicker and Its Atypical Manifestations: An Interesting Case Series

Clinical usefulness of the nested polymerase chain reaction in the diagnosis of extrapulmonary tuberculosis

Contact Info

Product

Resources

About