Polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems

Meng, Fanning; Hasan, Anwarul; Babadaei, Mohammad Mahdi Nejadi; Kani, Pegah Hashemi; Talaei, Amir Jouya; Sharifi, Majid; Cai, Tiange; Falahati, Mojtaba; Cai, Yu

doi:10.1016/j.jare.2020.07.017

Cited by 58 publications

(33 citation statements)

References 85 publications

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“…The main advantages of this type of MN are higher drug delivery capacity in comparison to solid, coated, and dissolving MN arrays (Larrañeta et al, 2016), where chemical substances, proteins, vaccines as well as oligonucleotides can be delivered in the skin (Pamornpathomkul et al, 2018a;Waghule et al, 2019). Due to the materials used for their fabrication, they exhibit also a high stiffness (Meng et al, 2020). In terms of limitations, blockage of the bore in needle tips with skin tissue upon insertion has been reported.…”

Section: Hollow Microneedlesmentioning

confidence: 99%

Hollow microneedles: A perspective in biomedical applications

Cárcamo-Martínez

Mallon

Domínguez-Robles

et al. 2021

International Journal of Pharmaceutics

153

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Section: Hollow Microneedlesmentioning

confidence: 99%

Hollow microneedles: A perspective in biomedical applications

Cárcamo-Martínez

Mallon

Domínguez-Robles

et al. 2021

International Journal of Pharmaceutics

153

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“…The matrix polymers for dissolving MNs usually have good biocompatibility. [ 100,101 ] The drugs trapped within the needle can be released after penetrating the dissolving MNs into skin. [ 30 ] According to their dissolution behaviors in vivo, the matrix polymers of dissolving MNs can be divided into water‐soluble, swellable, and biodegradable polymers.…”

Section: Materials and Classification Of Mnsmentioning

confidence: 99%

Recent Advances in Polymer Microneedles for Drug Transdermal Delivery: Design Strategies and Applications

Wang

Jiang

Aharodnikau

et al. 2022

Macromol. Rapid Commun.

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In recent years, transdermal drug delivery based on microneedles (MNs) technology has received extensive attention, which offers a safer and painless alternative to hypodermic needle injections. They can pierce the stratum corneum and deliver drugs to the epidermis and dermis-structures of skin, showing prominent properties such as minimally invasiveness, bypassing first-pass metabolism, and can be self-administered. A range of materials has been used to fabricate MNs, such as silicon, metal, glass, and polymers. Among them, polymer MNs have gained increasing attention from pharmaceutical and cosmetic companies as one of the promising drug delivery methods. MN products have recently become available on the market, and some of them are under evaluation for efficacy and safety. This paper focuses on the current state of polymer MNs in drug transdermal delivery. The materials and methods for the fabrication of polymer MNs and their drug administration are described. The recent progress of polymer MNs for treatment of cancer, vaccine delivery, blood glucose regulation, androgenetic alopecia, obesity, tissue healing, myocardial infarction, and gout are reviewed. The challenges of MNs technology are summarized and the future development trend of MNs is also prospected.

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“…此外, DNA疫苗对人类的免疫原性较差 [47,48] [52] . 经过近几十年的发展, 微针发展出了固体微针、中空聚合物微针和多孔微针 [53] 等几种类型, 其所用的材料多为多孔硅、聚合物 [54] 、陶瓷 [55] 以及不锈钢 [56] 等. 微针能将DNA递送至表皮层或真皮层, 多项研究表明, 用微针注射流感疫苗可以激发强有效的体液免疫反应, 并保护小鼠免受流感病毒的入侵 [57,58] .…”

Section: Dna疫苗递送方式的研究unclassified