Polymeric C-shaped cuff electrode for recording of peripheral nerve signal

Xue, Ning; Sun, Tao; Tsang, W.M.; Delgado-Martinez, Ignacio; Lee, Sang Hoon; Sheshadri, Swathi; Xiang, Zhuolin; Merugu, Srinivas; Gu, Yuandong; Yen, Shih Cheng; Thakor, Nitish V.

doi:10.1016/j.snb.2015.01.006

Cited by 46 publications

(28 citation statements)

References 29 publications

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“…Histological inspection showed the nanoclip implant provokes a typical fibrotic response, completely Interestingly, we found limited fibrotic penetration between the nerve and nanoclip up to 11 months after implant (Figure 2c), suggesting the potential for long-term viability of the preparation (Caravaca et al, 2017;Hiebl et al, 2010;Xiang et al, 2016;Xue et al, 2015).…”

Section: Uncompromised Nerve Function Following Implantmentioning

confidence: 72%

Printable microscale interfaces for long-term peripheral nerve mapping and precision control

Otchy

Michas

Lee

et al. 2019

Preprint

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The nascent field of bioelectronic medicine seeks to decode and modulate peripheral nervous system signals to obtain therapeutic control of targeted end organs and effectors. Current approaches rely heavily on electrodebased devices, but size scalability, material and microfabrication challenges, limited surgical accessibility, and the biomechanically dynamic implantation environment are significant impediments to developing and deploying advanced peripheral interfacing technologies. Here, we present a microscale implantable device -the nanoclipfor chronic interfacing with fine peripheral nerves in small animal models that begins to meet these constraints.We demonstrate the capability to make stable, high-resolution recordings of behaviorally-linked nerve activity over multi-week timescales. In addition, we show that multi-channel, current-steering-based stimulation can achieve a high degree of functionally-relevant modulatory specificity within the small scale of the device. These results highlight the potential of new microscale design and fabrication techniques for the realization of viable implantable devices for long-term peripheral interfacing.

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Section: Uncompromised Nerve Function Following Implantmentioning

confidence: 72%

Printable microscale interfaces for long-term peripheral nerve mapping and precision control

Otchy

Michas

Lee

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Cuff electrodes are broadly researched as peripheral nerve interfaces. They are fabricated with various designs and are still continuing to be developed in advanced forms [58][59][60][61][62][63][64][65][66]. These designs are named and classified according to their morphological properties [10].…”

Section: Extraneural Electrodesmentioning

confidence: 99%

“…It has shown good results in stimulating the pelvic nerve, the vagus nerve, and three branches of the sciatic nerve, as well as in the wireless stimulation of the pelvic nerve without implanting a power source [61]. The flexible split ring electrode consists of a polyimide-metal-polyimide sandwich structure with four triangular bendable gold electrodes coated by carbon nanotube, fabricated with microelectromechanical systems technology [62]. It permits easy surgical implantation as in the case of the flexible neural clip.…”

Section: Extraneural Electrodesmentioning

confidence: 99%

Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review

Yildiz

Shin

Kaufman

2020

J NeuroEngineering Rehabil

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The field of prosthetics has been evolving and advancing over the past decade, as patients with missing extremities are expecting to control their prostheses in as normal a way as possible. Scientists have attempted to satisfy this expectation by designing a connection between the nervous system of the patient and the prosthetic limb, creating the field of neuroprosthetics. In this paper, we broadly review the techniques used to bridge the patient's peripheral nervous system to a prosthetic limb. First, we describe the electrical methods including myoelectric systems, surgical innovations and the role of nerve electrodes. We then describe non-electrical methods used alone or in combination with electrical methods. Design concerns from an engineering point of view are explored, and novel improvements to obtain a more stable interface are described. Finally, a critique of the methods with respect to their long-term impacts is provided. In this review, nerve electrodes are found to be one of the most promising interfaces in the future for intuitive user control. Clinical trials with larger patient populations, and for longer periods of time for certain interfaces, will help to evaluate the clinical application of nerve electrodes.

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“…There are multiple variants of the cuff electrode. The split ring electrode is a flat ring which has been split at one side such that it can be placed around the nerve (Xue et al, 2015 ). Naples et al developed an electrode consisting of conductive segments embedded within a self-curling sheath of bio compatible insulation which gives it a “self-sizing” property (Naples et al, 1988 ).…”

Section: Electrodesmentioning

confidence: 99%

Update on Peripheral Nerve Electrodes for Closed-Loop Neuroprosthetics

2018

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In this paper various types of electrodes for stimulation and recording activity of peripheral nerves for the control of neuroprosthetic limbs are reviewed. First, an overview of interface devices for (feedback-) controlled movement of a prosthetic device is given, after which the focus is on peripheral nervous system (PNS) electrodes. Important electrode properties, i.e., longevity and spatial resolution, are defined based upon the usability for neuroprostheses. The cuff electrode, longitudinal intrafascicular electrodes (LIFE), transverse intrafascicular multichannel electrode (TIME), Utah slanted electrode array (USEA), and the regenerative electrode are discussed and assessed on their longevity and spatial resolution. The cuff electrode seems to be a promising electrode for the control of neuroprostheses in the near future, because it shows the best longevity and good spatial resolution and it has been used on human subjects in multiple studies. The other electrodes may be promising in the future, but further research on their longevity and spatial resolution is needed. A more quantitatively uniform study protocol used for all electrodes would allow for a proper comparison of recording and stimulation performance. For example, the discussed electrodes could be compared in a large in vivo study, using one uniform comparison protocol.

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Polymeric C-shaped cuff electrode for recording of peripheral nerve signal

Cited by 46 publications

References 29 publications

Printable microscale interfaces for long-term peripheral nerve mapping and precision control

Printable microscale interfaces for long-term peripheral nerve mapping and precision control

Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review

Update on Peripheral Nerve Electrodes for Closed-Loop Neuroprosthetics

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