Polymeric capsules and micelles as promising carriers of anticancer drugs

Kubiak, Tomasz

doi:10.17219/pim/145513

Cited by 12 publications

(5 citation statements)

References 132 publications

(172 reference statements)

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“…NK012 is a polymeric micelle formulation of SN-38, the active metabolite of irinotecan [ 219 ]. NK012 releases its active ingredient via hydrolysis and does not require metabolic conversion by enzymes.…”

Section: Clinical Trials On Micellar Drug Delivery Systemsmentioning

confidence: 99%

Exploring the Application of Micellar Drug Delivery Systems in Cancer Nanomedicine

Wang

Atluri²,

Tiwari

et al. 2023

Pharmaceuticals

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Various formulations of polymeric micelles, tiny spherical structures made of polymeric materials, are currently being investigated in preclinical and clinical settings for their potential as nanomedicines. They target specific tissues and prolong circulation in the body, making them promising cancer treatment options. This review focuses on the different types of polymeric materials available to synthesize micelles, as well as the different ways that micelles can be tailored to be responsive to different stimuli. The selection of stimuli-sensitive polymers used in micelle preparation is based on the specific conditions found in the tumor microenvironment. Additionally, clinical trends in using micelles to treat cancer are presented, including what happens to micelles after they are administered. Finally, various cancer drug delivery applications involving micelles are discussed along with their regulatory aspects and future outlooks. As part of this discussion, we will examine current research and development in this field. The challenges and barriers they may have to overcome before they can be widely adopted in clinics will also be discussed.

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Section: Clinical Trials On Micellar Drug Delivery Systemsmentioning

confidence: 99%

Exploring the Application of Micellar Drug Delivery Systems in Cancer Nanomedicine

Wang

Atluri²,

Tiwari

et al. 2023

Pharmaceuticals

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“…One of the most relevant properties of these systems is that they need to present high biocompatibility. This means that they cannot be toxic, but they should also fulfil a planned role in the biological environment [ 54 ]. These systems can be classified depending on their structure into different groups ( Table 1 and Figure 2 ), with some of the most used systems to encapsulate bioactives as follows:…”

Section: Emulsion-based Delivery Systems To Carry Bioactive Compoundsmentioning

confidence: 99%

Emulsion-Based Delivery Systems to Enhance the Functionality of Bioactive Compounds: Towards the Use of Ingredients from Natural, Sustainable Sources

Teixé-Roig

Oms‐Oliu

Odriozola-Serrano

et al. 2023

Foods

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In recent years, the trend in the population towards consuming more natural and sustainable foods has increased significantly. This claim has led to the search for new sources of bioactive compounds and extraction methods that have less impact on the environment. Moreover, the formulation of systems to protect these compounds is also focusing on the use of ingredients of natural origin. This article reviews novel, natural alternative sources of bioactive compounds with a positive impact on sustainability. In addition, it also contains information on the most recent studies based on the use of natural (especially from plants) emulsifiers in the design of emulsion-based delivery systems to protect bioactive compounds. The properties of these natural-based emulsion-delivery systems, as well as their functionality, including in vitro and in vivo studies, are also discussed. This review provides relevant information on the latest advances in the development of emulsion delivery systems based on ingredients from sustainable natural sources.

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“…However, in order to ensure their stability and biocompatibility, it is necessary to cover them with an appropriate polymer. One should remember that broadly defined biocompatibility is understood not only as a lack of toxicity and immunogenicity, but also the ability to perform the planned role in the biological environment [6]. Therefore, it is important to investigate the behavior of functionalized nanoparticles in various media, especially in aqueous solutions and body fluids such as plasma or blood.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Blood and Serum Microenvironment on Spin-Labeled Magnetic Nanoparticles

Kubiak

2024

Magnetism

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The investigation and clarification of the properties of surface-functionalized superparamagnetic nanoparticles in a biological environment are key challenges prior to their medical applications. In the present work, electron paramagnetic resonance spectroscopy (EPR) combined with the spin labeling technique was utilized to better understand the behavior of nitroxides attached to magnetite nanoparticles dispersed in body fluid. EPR spectra of spin-labeled, silane-coated Fe3O4 nanoparticles in human serum and whole blood were recorded and analyzed for both room- and low-temperature values. In all cases, the obtained EPR signal consisted of a broad line from magnetite cores and a characteristic signal from the attached 4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO). Even for liquid samples, the anisotropic components of magnetic tensors did not fully average out, which was reflected in the differences in the intensity of three narrow hyperfine lines from nitroxide. At 230 K the irregular slow-motion signal from the attached radical was also simulated using the EasySpin toolbox, which allowed to determine the parameters related to magnetic tensors and the dynamics of the spin label. The study showed that the anisotropy of the motion of the spin label 4-amino-TEMPO reflects its interactions with the surrounding medium and the manner of the attachment of the nitroxide to the surface of nanoparticles.

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Polymeric capsules and micelles as promising carriers of anticancer drugs

Abstract: Kubiak T. Polymeric capsules and micelles as promising carriers of anticancer drugs [published online as ahead of print on February 23, 2022].

Cited by 12 publications

References 132 publications

Exploring the Application of Micellar Drug Delivery Systems in Cancer Nanomedicine

Exploring the Application of Micellar Drug Delivery Systems in Cancer Nanomedicine

Emulsion-Based Delivery Systems to Enhance the Functionality of Bioactive Compounds: Towards the Use of Ingredients from Natural, Sustainable Sources

The Influence of Blood and Serum Microenvironment on Spin-Labeled Magnetic Nanoparticles

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