Polymeric Complexes of Isonicotinic Acid Hydrazide with Antituberculosis Effects

Abstract

We studied the effects of an analogue of isonicotinic acid hydrazide on the treatment course of experimental tuberculosis. Complex analysis has demonstrated the efficiency of isonicotinic acid hydrazide immobilized on a carrier that consisted of water-soluble cation-active analogue of chitosan (N-chlorohydroxypropyl chitosan) in a complex with cobalt ions in the therapy of experimental tuberculosis. Immunostimulating activity of the polymeric metal complex was revealed. The obtained data can be used for the development of highly effective methods for tuberculosis treatment.

Transition metal complexes of a hydrazone–oxime ligand containing the isonicotinoyl moiety: Synthesis, characterization and microbicide activities

“…The obtained complexes (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) are air-stable and have assorted colours. The complexes are insoluble in water and soluble in polar aprotic solvents like DMF and DMSO.…”

“…[11,12] For example a V 3+ complex catalyses ethylene polymerization. [13] In addition, polymeric complexes of isonicotinic acid hydrazide shows anti-tuberculosis effects, [14] while isonicotinic Cu 2+ complexes possess antiviral activity. [15] Moreover, the toxicity of a Zn 2+ complex with mycobactericidal drug isoniazid (isonicotinohydrazide) is nearly 8.5 times greater than that of isonicotinohydrazide itself against Artemia salina.…”