Polymeric Complexes of Ofloxacin and Their Activity Against Tuberculosis Mycobacteria

Соловский, М. В.; Борисенко, М. С.; Vlasova, E. N.; Тарабукина, Е. Б.; Захарова, Н. В.; Праздникова, Т. А.

doi:10.1007/s11094-017-1592-5

Cited by 2 publications

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…42 Strategies for ofloxacin included cellulose conjugate, nanofibers, polymeric complex and nanoparticles. [59][60][61][62][63] In vivo studies using nanofibers depicted its role as ofloxacin reservoir, increasing its residence time in the gastrointestinal tract.…”

Section: Complex Formationmentioning

confidence: 99%

Innovative drug delivery systems for leprosy treatment

Rocha¹,

Barbosa²,

Araujo³

et al. 2022

IJDVL

View full text Add to dashboard Cite

Most drugs used for leprosy treatment have low water solubility, which limits their bioavailability. [14][15][16] Accordingly, administration of high doses required for reaching therapeutic blood levels aggravate adverse effects. Poor water solubility of these drugs may also result in their variable serum concentration, thus increasing the likelihood of bacterial resistance. [17][18][19] Additionally, rifampicin and clofazimine bioavailability may be limited, respectively, by stomach degradation and recrystallization depending on pH. 11,20,21 Unlike other drugs, minocycline is highly water soluble, its major limitation being intestinal permeability. 22 New formulations have been proposed for leprosy therapy to address these problems. This article aims to highlight the recent advances in drug delivery systems, which may be utilized to overcome these hurdles. Innovative pharmaceutical strategies towards enhancement of therapeutic efficacyRecent advances in drug delivery systems may overcome solubility impairment, common in pharmaceutical development. 23 The oral formulations proposed for multidrug therapy drugs are focused on two main strategies: increasing the apparent drug water solubility or modifying the drug release.Figure 1 summarizes the improvements and the expected results of multidrug therapy innovative formulations. In vitro evaluation, in vivo, and in silico performances of these preparations are provided in Table 1, if available, showing their potential therapeutic efficacy. As the following steps,

show abstract

Section: Complex Formationmentioning

confidence: 99%

Innovative drug delivery systems for leprosy treatment

Rocha¹,

Barbosa²,

Araujo³

et al. 2022

IJDVL

View full text Add to dashboard Cite

show abstract

Сверхсшитые Полимерные Сорбенты, Модифицированные 4-Винилпиридином: Синтез, Адсорбционные Свойства И Применение Для Выделения Полимерной Соли Цефуроксима В Режиме Флэш-Хроматографии

Кириллов,

Вагин,

Борисенко

et al. 2024

Žurnal prikladnoj himii

View full text Add to dashboard Cite

Синтезированы сверхсшитые полимерные сорбенты на основе терполимеров стирола, дивинилбензола и 4-винилпиридина. Пористая и химическая структура сорбентов исследована с помощью методов низкотемпературной адсорбции–десорбции азота и инфракрасной спектроскопии. Определены адсорбционные характеристики сорбентов по отношению к цефуроксиму в статических и динамических условиях. Установлено, что введение 4-винилпиридина в полимерную матрицу сорбентов способствует усиленной адсорбции цефуроксима. Показана возможность применения пиридинсодержащих сверхсшитых полимерных сорбентов для разделения соли поли(акриламид-со-2-аминоэтилметакрилат)а с цефуроксимом и свободного цефуроксима в режиме флэш-хроматографии. Чистота полимерной соли цефуроксима после выделения подтверждена с помощью высокоэффективной жидкостной хроматографии в эксклюзионном режиме.

show abstract

Polymeric Complexes of Ofloxacin and Their Activity Against Tuberculosis Mycobacteria

Cited by 2 publications

References 2 publications

Innovative drug delivery systems for leprosy treatment

Innovative drug delivery systems for leprosy treatment

Contact Info

Product

Resources

About