Polymeric composites containing carbon nanotubes for bone tissue engineering

Sahithi, Kolli; Swetha, M.; Ramasamy, Kumarasamy; Srinivasan, Narasimhan; Selvamurugan, N.

doi:10.1016/j.ijbiomac.2010.01.006

Cited by 148 publications

(69 citation statements)

References 34 publications

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“…Functionalized CNTs can, however, remain dispersed and stable in aqueous solutions and are used for biomedical purposes such as drug delivery 9 . Here it is essential that the CNTs remain dispersed and mobilized, so the drug can be delivered within the human body 10 . On the other hand, to reduce environmental risks, there is a need for studies focusing on how to immobilize the CNTs in order to avoid their entrance into aquifers and drinking water resources 11 .…”

Section: Introductionmentioning

confidence: 99%

Transport of Surface-modified Carbon Nanotubes through a Soil Column

Sharma

Fagerlund

2015

JoVE

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Carbon nanotubes (CNTs) are widely manufactured nanoparticles, which are being utilized in a number of consumer products, such as sporting goods, electronics and biomedical applications. Due to their accelerating production and use, CNTs constitute a potential environmental risk if they are released to soil and groundwater systems. It is therefore essential to improve the current understanding of environmental fate and transport of CNTs. The transport and retention of CNTs in both natural and artificial media have been reported in literature, but the findings widely vary and are thus not conclusive. There are a number of physical and chemical parameters responsible for variation in retention and transport. In this study, a complete procedure of selected multiwalled carbon nanotubes (MWCNTs) is presented starting from their surface modification to a complete set of laboratory column experiments at critical physical and chemical scenarios. Results indicate that the stability of the commercially available MWCNTs are critical with their attached surface functional group which can also influence the transport and retention of MWCNT through the surrounding medium. Video LinkThe video component of this article can be found at

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Section: Introductionmentioning

confidence: 99%

Transport of Surface-modified Carbon Nanotubes through a Soil Column

Sharma

Fagerlund

2015

JoVE

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“…17 Considering their excellent mechanical properties, cytocompatibility, and electrical properties, they have received a lot of attention for bone tissue engineering. [18][19][20][21][22][23] Their nanofibrous geometry also simulates the extracellular matrix in bone. Carbon nanotubes can be synthesized through arc discharge, laser ablation, and chemical vapor deposition.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic three-dimensional nanocrystalline hydroxyapatite and magnetically synthesized single-walled carbon nanotube chitosan nanocomposite for bone regeneration

Li²,

Wang³

et al. 2012

IJN

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Background: Many shortcomings exist in the traditional methods of treating bone defects, such as donor tissue shortages for autografts and disease transmission for allografts. The objective of this study was to design a novel three-dimensional nanostructured bone substitute based on magnetically synthesized single-walled carbon nanotubes (SWCNT), biomimetic hydrothermally treated nanocrystalline hydroxyapatite, and a biocompatible hydrogel (chitosan). Both nanocrystalline hydroxyapatite and SWCNT have a biomimetic nanostructure, excellent osteoconductivity, and high potential to improve the load-bearing capacity of hydrogels. Methods: Specifically, three-dimensional porous chitosan scaffolds with different concentrations of nanocrystalline hydroxyapatite and SWCNT were created to support the growth of human osteoblasts (bone-forming cells) using a lyophilization procedure. Two types of SWCNT were synthesized in an arc discharge with a magnetic field (B-SWCNT) and without a magnetic field (N-SWCNT) for improving bone regeneration. Results: Nanocomposites containing magnetically synthesized B-SWCNT had superior cytocompatibility properties when compared with nonmagnetically synthesized N-SWCNT. B-SWCNT have much smaller diameters and are twice as long as their nonmagnetically prepared counterparts, indicating that the dimensions of carbon nanotubes can have a substantial effect on osteoblast attachment. Conclusion: This study demonstrated that a chitosan nanocomposite with both B-SWCNT and 20% nanocrystalline hydroxyapatite could achieve a higher osteoblast density when compared with the other experimental groups, thus making this nanocomposite promising for further exploration for bone regeneration.

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“…Then, CNTs behave like an inert matrix to support cell proliferation, their effect along with other natural or synthetic materials as biocomposites would be more effective in bone tissue engineering applications. Bone cell functions are stimulated under electrical current, and therefore conductive nanoadditives like carbon nanotubes may play a role in promoting osteoblast growth and proliferation [6].…”

Section: Introductionmentioning

confidence: 99%

The Study of Human Osteoblast-Like MG 63 Cells Proliferation on Resorbable Polymer-Based Nanocomposites Modified with Ceramic and Carbon Nanoparticles

et al. 2012

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Polymer-based nanocomposites containing biocompatible and bioactive nanocomponents seem to be excellent materials that could be used in many biomedical applications. The aim of this study was biological evaluation of resorbable polymer-based nanocomposites (PLA, PCL) and their modifications with ceramic nanoparticles (silica -SiO 2 , montmorylonit -MMT) or carbon nanotubes. The nanocomposites were seeded with the human osteoblast-like MG 63 cells. After 1, 3 and 7 days of incubation, Trypan blue exclusion test was used to determine the viability and number of cells. The cell population density depending on incubation time and cell population doubling time was calculated. The cell proliferation abilities on the all applied nanocomposites and on control material (polystyrene cell culture plate) were also compared. The number of cells growing on the nanocomposite surfaces increased with the incubation time. The cell viability was not decreased for all applied materials during the entire study (97-100%). The ceramic nanoparticles and carbon nanotubes modified the bone cell growth and proliferation rate. Results of this study confirm that all types of the nanocomposites are appropriate to the growing and proliferation of human osteoblast-like cells.

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Polymeric composites containing carbon nanotubes for bone tissue engineering

Cited by 148 publications

References 34 publications

Transport of Surface-modified Carbon Nanotubes through a Soil Column

Transport of Surface-modified Carbon Nanotubes through a Soil Column

Biomimetic three-dimensional nanocrystalline hydroxyapatite and magnetically synthesized single-walled carbon nanotube chitosan nanocomposite for bone regeneration

The Study of Human Osteoblast-Like MG 63 Cells Proliferation on Resorbable Polymer-Based Nanocomposites Modified with Ceramic and Carbon Nanoparticles

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