Polymeric Delivery Systems for Biopharmaceuticals

Dinarvand, Rassoul; Dorkoosh, Farid Abedin; Hamidi, Mehrdad; Moghadam, Shadi H.

doi:10.1080/02648725.2004.10648053

Cited by 12 publications

(4 citation statements)

References 191 publications

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“…Heller has defined three mechanisms of polymer bioerosion in 1980 [28]. Mechanism I or crosslinked degradation concerns crosslinked water insoluble macromolecules that contain hydrolytically unstable cross-links.…”

Section: Chemical Erosionmentioning

confidence: 99%

Biodegradable Synthetic Polymers and their Application in Advanced Drug Delivery Systems (DDS)

Jerbić¹

2018

Nano Tech Appl

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Natural and synthetic polymers have been used in pharmaceutical industry for many years and have important role in the development of the conventional dosage forms or for manufacturing of various drug packaging materials. In recent years, their important application resides in the development of the most sophisticated drug delivery systems where polymers are used as a drug carrier. Biodegradable polymers are particularly attractive for application in drug delivery systems since, once introduced into the human body, they do not require removal or additional manipulation. Their degradation products are normal metabolites of the body or products that can be metabolized and easily cleared from the body. Among that, synthetic polymers offer a wide variety of compositions with adjustable properties. These materials open the possibility of developing new drug delivery systems with specific properties (chemical, interfacial, mechanical and biological) for a given application, simply by changing the building blocks or the preparation technique. Such designed complex drug delivery systems where polymers are used as functional excipients have numerous advantages such as localized delivery of drug, sustained delivery of drug, stabilization of the drug, prevention of drug's adverse side-effects, reduction of dosing frequency, minimization of drug concentration fluctuations in plasma level, improved drug utilization and patient compliance. There are range of differently designed drug delivery systems and their description and mechanism of action will be presented in this paper together with the prominent role of the polymers for each particular system. Additionally, most commonly used synthetic biodegradable polymers in drug delivery systems will be presented together with their degradation mechanism.

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Section: Chemical Erosionmentioning

confidence: 99%

Biodegradable Synthetic Polymers and their Application in Advanced Drug Delivery Systems (DDS)

Jerbić¹

2018

Nano Tech Appl

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“…However, they suffer from drawbacks such as the possibility of undesired insertion mutagenesis, the induction of immune response against the vector, the limitation in their size of the delivered transgene, and quite a high cost of their large‐scale production. Due to these significant limitations, nonviral vectors have been proposed as an alternative to viral vectors . In recent years, several cationic polymers have been used as nonviral gene carriers including synthetic polymers, such as polyethyleneimine (PEI) , dendrimers , poly‐ l ‐lysine , and natural polymers, such as alginate , albumin , and chitosan .…”

Section: Introductionmentioning

confidence: 99%

Targeted DNA delivery to cancer cells using a biotinylated chitosan carrier

Darvishi

Nomani

Hashemzadeh

et al. 2017

Biotech and App Biochem

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A novel biotinylated chitosan-graft-polyethyleneimine (Bio-Chi-g-PEI) copolymer was synthesized and evaluated as a nonviral gene delivery carrier for improvement of the transfection efficiency, endosomal escape, and targeted gene delivery of a plasmid encoding green fluorescent protein N1 (pEGFP-N1) into two different biotin-overexpressing cell lines including HeLa and OVCAR-3 cells. The structure of the obtained copolymers was confirmed by H nuclear magnetic resonance ( H NMR) and Fourier transform infrared spectroscopy. Physicochemical properties of the Bio-Chi-g-PEI/plasmid DNA (pDNA) complexes such as complex stability, size, zeta potential, and their morphology were investigated at various weight ratios of copolymer to pDNA. Bio-Chi-g-PEI copolymers could effectively condense pDNA into small particles with average diameters less than 164 nm and the zeta potential of +34.8 mV at the N/P ratio of 40/1. As revealed by flow cytometry, Bio-Chi-g-PEI/pDNA complexes had lower cytotoxicity than that of PEI 25 kDa/pDNA complexes in both cell lines. In vitro experiments revealed that the Bio-Chi-gPEI/pDNA complexes not only had much lower cytotoxicity, but also displayed higher transfection efficiency than that of PEI 25kDa/pDNA complexes. High percentage of cancer cells was successfully transfected by Bio-Chi-g-PEI/pDNA and properly expressed GFP protein. This study indicates that this copolymer complex can be a promising gene delivery carrier.

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“…Due to technological improvement and thanks to merging in pharmaceutical sciences during the recent 30 years, polymers have found a wide range of applications in this field with functions that encompass simple tasks such as solubilizer, stabilizer, tablet film coater and binder to more complicated ones such as drug release modulation, drug targeting and responsiveness to environmental stimuli as smart polymers (1)(2)(3). Polymers in drug delivery perform their function either by governing time control or location control (4).…”

Section: Introductionmentioning

confidence: 99%

Development of Molecularly Imprinted Olanzapine Nano-particles: In Vitro Characterization and In Vivo Evaluation

et al. 2016

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Abstract. Molecularly imprinted nano-particles (MINPs) selective for olanzapine were prepared using methacrylic acid (MA) as monomer, ethylene glycol dimethacrylate (EGDMA) as a cross-linker, and 2,2-azobis (2-isobutyronitrile) (AIBN) as the initiator in 36 different ratios. The reaction runs with considerable fine powder formation were selected for further binding and selectivity studies. The MINP with the best selectivity (MINP-32) was chosen for further structural characterization by Fourier transform infrared spectroscopy (FT-IR), thermal gravimetric analysis (TGA), scanning electron microscopy (SEM), adsorption-desorption isotherm for specific surface area, volume and average pore diameter determination. All characterization methods confirmed the successful formation of MINP. The optimum conditions for maximum template loading on the MINP-32 were found by experimental design using response surface methodology (RSM) and choosing absorbent amount, pH, and time as the main factors. MINPs with maximum template loading also indicated significant selectivity between template and its analog (clozapine). The release profile demonstrated a maximum release of about 95% after 288 h for MINP-32 in comparison with about 94% after 120 h for non-MINP-32. The same slow release of drug from MINP-32 was also observed during animal study of the plasma level of template, 20-28 μg/ml versus 5-10 μg/ml. The MINP-32 of this study represents a desirable ability to keep the memory of the template with significant selectivity and good capability to control the release of template in vitro and in vivo and hence could be a promising drug delivery system.

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Polymeric Delivery Systems for Biopharmaceuticals

Cited by 12 publications

References 191 publications

Biodegradable Synthetic Polymers and their Application in Advanced Drug Delivery Systems (DDS)

Biodegradable Synthetic Polymers and their Application in Advanced Drug Delivery Systems (DDS)

Targeted DNA delivery to cancer cells using a biotinylated chitosan carrier

Development of Molecularly Imprinted Olanzapine Nano-particles: In Vitro Characterization and In Vivo Evaluation

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